Abstract: The present disclosure relates to a multispecific antibody platform for targeted degradation of cell surface proteins. The disclosure relates to multispecific (e.g., bispecific or trispecific) binding molecules such as multispecific antibodies that target at least one transmembrane E3 ubiquitin ligase protein and at least one cell surface protein, for example, a cell surface protein that is intended for degradation, and methods of using the same.

Abstract: A chemical mechanical planarization (CMP) pad conditioner assembly includes a backing plate including at least one polymer and at least one additive. The at least one additive is present in an amount sufficient to result in a backing plate having at least one of a magnetic property, a color property, a structural property, or any combination thereof. The CMP pad conditioner assembly includes a plurality of segments including a ceramic substrate and a plurality of laser textured protrusions integral with the ceramic substrate. The plurality of laser textured protrusions is coated with a conformal diamond layer.

Abstract: A pad conditioner and chemical mechanical planarization (CMP) pad conditioner assembly for a CMP assembly are disclosed. The pad conditioner includes a substrate having a first surface and a second surface opposite the first surface. A plurality of protrusions protrude away from the first surface in a direction that is normal to the first surface. The plurality of protrusions are arranged in a plurality of rows. A first row of the plurality of rows is offset from a second row of the plurality of rows.

Abstract: Circuits and methods for maintaining a substantially constant input and output current for a charge pump circuit are provided which reduce current variation during switching intervals. The charge pump circuitry of the present invention maintains a current flow path from a current source to the charge pump output which minimizes or eliminates spikes normally associated with the switching intervals.

Abstract: Circuits and methods for maintaining a substantially constant input and output current for a charge pump circuit are provided which reduce current variation during switching intervals. The charge pump circuitry of the present invention maintains a current flow path from a current source to the charge pump output which minimizes or eliminates spikes normally associated with the switching intervals.

Abstract: Systems and methods for reducing the magnitude of signal dependent capacitance are provided. Capacitance canceling circuitry is operative to generate cancellation capacitance in response to the magnitude of a signal, which may be the same signal that produces the undesired signal dependent capacitance, to at least partially cancel the signal dependent capacitance.