Abstract: This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.

Abstract: This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.

Abstract: This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.

Abstract: Disclosed herein are neuroprotective compounds. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of neurodegenerative conditions are provided.

Abstract: This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.

Abstract: This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.

Abstract: A wireline logging method including estimating a data rate requirement associated with a tool string to be connected to a wireline cable and determining an operating characteristic of a wireline cable at the surface. The operating characteristic is indicative of the wireline cable's data rate capacity. Before inserting the wireline cable into a well bore, a down hole value of the operating characteristic is modeled and a down hole data rate capacity is derived based thereon. Upon determining that the estimated data rate requirement does not match the down hole data rate capacity, the tool string is modified to remove or add tools to the tools string to match the tool strings data rate requirements with the estimated data rate capacity of the tool string and cable.

Abstract: This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using heterocyclic thioesters and ketones.

Abstract: The present invention provides the inhibitors of dipeptidyl peptidase IV based upon or including proline or similar moieties. The inhibitors are useful for treating various disorders, including those of the central nervous system and the prostate. Many of the inhibitors can be reversible, and can cross the blood-brain barrier. Methods of making and using the inhibitors and treatment methods also are provided.

Abstract: There is utilized a particular bucket conveyor apparatus for the transport of fragile articles such as cookies and crackers from an input feed point to a multiple number of discharge areas. At the discharge areas the bucket conveyors are tilted rearwardly to spread the fragile crackers and cookies over a lower transverse belt or vibrating conveyor. In the operation of the apparatus each of the buckets is filled initially to less than about 50 percent of its volume. In this way if there is not an available discharge point, the bucket can once again go through the cycle before it would reach a point of overflowing. When the buckets are in a full condition, they will empty half or more of their contents onto a storage station conveyor prior to passing the input feed point. This bucket conveyor mechanism lends itself to a high degree of computerized control.