Patents by Inventor Joseph Sypek

Joseph Sypek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant Heme Oxygenase-1 (HO-1) for the Treatment of Sickle Cell Disease
    Publication number: 20230018417
    Abstract: The present invention provides, among other things, methods and compositions for making and using recombinant heme oxygenase for treating sickle cell disease. In some embodiments, recombinant heme oxygenase proteins are truncation variants, or Fc fusion proteins with increased half-life and/or reduced aggregation.
    Type: Application
    Filed: July 24, 2020
    Publication date: January 19, 2023
    Inventors: Solomon Fiifi Ofori-Acquah, Samit Ghosh, Joseph Sypek, Bohong Zhang, Xiuxia Sun, Clark Q. Pan, Daniel Minard Lajole, Chuan Shen
  • Use of rapamycin and agents that inhibit B7 activity in immunomodulation
    Publication number: 20070092506
    Abstract: The invention provides methods for downmodulating an immune response comprising contacting immune cells from a subject with at least one agent that binds to at least one B7 molecule in combination with a Rapamycin compound.
    Type: Application
    Filed: October 24, 2006
    Publication date: April 26, 2007
    Applicant: Genetics Institute, LLC
    Inventors: Joseph Sypek, Mark Collins
  • Use of rapamycin and agents that inhibit B7 activity in immunomodulation
    Publication number: 20010055593
    Abstract: The invention provides methods for downmodulating an immune response comprising contacting immune cells from a subject with at least one agent that binds to at least one B7 molecule in combination with a Rapamycin compound.
    Type: Application
    Filed: March 13, 2001
    Publication date: December 27, 2001
    Inventors: Joseph Sypek, Mark J. Collins