Patents by Inventor Joseph T. Chang

Joseph T. Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SPECIFIC GRP78 EXPRESSION-INHIBITION RNAi SEQUENCE, MEDICINE THEREOF AND METHOD THEREOF
    Publication number: 20110008882
    Abstract: The present invention discloses a specific GRP78 expression-inhibition RNAi sequence, a medicine thereof and a method thereof, wherein an RNAi sequence 5?-AAGGATGGTTAATGATGCTGAGAA-3? [SEQ. ID NO: 1] complementary to GRP78 forms a special hair-pin structure inside cancer cells to specifically and effectively inhibit GRP78 expression and then inhibit the canceration process, including the growth, migration, invasion, and metastasis of cancer.
    Type: Application
    Filed: April 30, 2009
    Publication date: January 13, 2011
    Inventors: ANN-JOY CHENG, JOSEPH T. CHANG, CHING-CHI CHIU
  • LABELED MOLECULE FOR PROGNOSING TUMOR GRADE OF HEAD AND NECK CANCER AND METHOD FOR THE SAME
    Publication number: 20110008821
    Abstract: The present invention discloses a labeled molecule for prognosing the tumor grade of head and neck cancer and a method for the same, wherein a 78-kDA glucose regulated protein (GRP78) is adopted as a labeled molecule of head and neck cancer. GRP78 is much more overexpressed in head and neck cancer cells than in non-cancer cells. GRP78 also has relation with tumor size, tumor depth and tumor metastasis. Therefore, the present invention uses GRP78 overexpression as a reference for tumor grading of head and neck cancer.
    Type: Application
    Filed: September 23, 2010
    Publication date: January 13, 2011
    Inventors: Ann-Joy CHENG, Joseph T. Chang, Ching-Chi Chiu
  • Specific GRP78 expression-inhibition RNAi sequence, medicine thereof and method thereof
    Patent number: 7829695
    Abstract: The present invention discloses a specific GRP78 expression-inhibition RNAi sequence, a medicine thereof and a method thereof, wherein an RNAi sequence 5?-AAGGATGGTTAATGATGCTGAGAA-3? complementary to GRP78 forms a special hair-pin structure inside cancer cells to specifically and effectively inhibit GRP78 expression and then inhibit the canceration process, including the growth, migration, invasion, and metastasis of cancer.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: November 9, 2010
    Assignee: Chang Gung University
    Inventors: Ann-Joy Cheng, Joseph T. Chang, Ching-Chi Chiu
  • Specific GRP78 expression-inhibition RNAi sequence, medicine thereof and method thereof
    Patent number: 7825100
    Abstract: The present invention discloses a specific GRP78 expression-inhibition RNAi sequence, a medicine thereof and a method thereof, wherein an RNAi sequence 5?-AAGGATGGTTAATGATGCTGAGAA-3? complementary to GRP78 forms a special hair-pin structure inside cancer cells to specifically and effectively inhibit GRP78 expression and then inhibit the canceration process, including the growth, migration, invasion, and metastasis of cancer.
    Type: Grant
    Filed: April 30, 2009
    Date of Patent: November 2, 2010
    Assignee: Chang Gung University
    Inventors: Ann-Joy Cheng, Joseph T. Chang, Ching-Chi Chiu
  • SPECIFIC GRP78 EXPRESSION-INHIBITION RNAi SEQUENCE, MEDICINE THEREOF AND METHOD THEREOF
    Publication number: 20100009435
    Abstract: The present invention discloses a specific GRP78 expression-inhibition RNAi sequence, a medicine thereof and a method thereof, wherein an RNAi sequence 5?-AAGGATGGTTAATGATGCTGAGAA-3? complementary to GRP78 forms a special hair-pin structure inside cancer cells to specifically and effectively inhibit GRP78 expression and then inhibit the canceration process, including the growth, migration, invasion, and metastasis of cancer.
    Type: Application
    Filed: April 30, 2009
    Publication date: January 14, 2010
    Inventors: ANN-JOY CHENG, JOSEPH T. CHANG, CHING-CHI CHIU
  • SPECIFIC GRP78 EXPRESSION-INHIBITION RNAi SEQUENCE, MEDICINE THEREOF AND METHOD THEREOF
    Publication number: 20090181913
    Abstract: The present invention discloses a specific GRP78 expression-inhibition RNAi sequence, a medicine thereof and a method thereof, wherein an RNAi sequence 5?-AAGGATGGTTAATGATGCTGAGAA-3? complementary to GRP78 forms a special hair-pin structure inside cancer cells to specifically and effectively inhibit GRP78 expression and then inhibit the canceration process, including the growth, migration, invasion, and metastasis of cancer.
    Type: Application
    Filed: July 17, 2008
    Publication date: July 16, 2009
    Inventors: Ann-Joy CHENG, Joseph T. Chang, Ching-Chi Chiu
  • LABELED MOLECULE FOR PROGNOSING TUMOR GRADE OF HEAD NECK CANCER AND METHOD FOR THE SAME
    Publication number: 20090181472
    Abstract: The present invention discloses a labeled molecule for prognosing the tumor grade of head neck cancer and a method for the same, wherein a 78-kDA glucose regulated protein (GRP78) is adopted as a labeled molecule of head neck cancer. GRP78 is much more overexpressed in head neck cancer cells than in non-cancer cells. GRP78 also has relation with tumor size, tumor depth and tumor metastasis. Therefore, the present invention uses GRP78 overexpression as a reference for tumor grading of head neck cancer.
    Type: Application
    Filed: May 8, 2008
    Publication date: July 16, 2009
    Inventors: Ann-Joy CHENG, Joseph T. Chang, Ching-Chi Chiu