Patents by Inventor Joseph T. Woitach

Joseph T. Woitach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • cDNA Encoding a Gene Bog (B5T Over-Expressed Gene) and its Protein Product
    Publication number: 20100129791
    Abstract: Nucleic acids that encode novel polypeptides, designated in the present application as “BOG” (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-?1 as well as in primary liver tumors. Compositions including BOG chimeras, nucleic acids encoding BOG and antibodies to BOG are also provided. Methods of using BOG to modulate pRb-protein interactions and to alter cellular phenotype are further provided.
    Type: Application
    Filed: December 14, 2007
    Publication date: May 27, 2010
    Applicant: The Government of the United State, as represented by the Secretary, Dept. of Health & Human Service
    Inventors: Snorri S. Thorgeirsson, Joseph T. Woitach, Minghuang Zhang
  • cDNA encoding a gene BOG (B5T over-expressed gene) and its protein product
    Patent number: 7342099
    Abstract: Nucleic acids that encode novel polypeptides, designated in the present application as “BOG” (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-?1 as well as in primary liver tumors. Compositions including BOG chimeras, nucleic acids encoding BOG and antibodies to BOG are also provided. Methods of using BOG to modulate pRb-protein interactions and to alter cellular phenotype are further provided.
    Type: Grant
    Filed: February 5, 2004
    Date of Patent: March 11, 2008
    Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services
    Inventors: Snorri S. Thorgeirsson, Joseph T. Woitach, Minghuang Zhang
  • cDNA encoding a gene BOG (B5T over-expressed gene) and its protein product
    Publication number: 20040139485
    Abstract: Nucleic acids that encode novel polypeptides, designated in the present application as “BOG” (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-&bgr;1 as well as in primary liver tumors. Compositions including BOG chimeras, nucleic acids encoding BOG and antibodies to BOG are also provided. Methods of using BOG to modulate pRb-protein interactions and to alter cellular phenotype are further provided.
    Type: Application
    Filed: February 5, 2004
    Publication date: July 15, 2004
    Applicant: The Government of the U.S. A, as presented by the Secretary, Department of Health and Human Services
    Inventors: Snorri S. Thorgeirsson, Joseph T. Woitach, Minghuang Zhang
  • cDNA encoding a gene BOG (B5T Over-expressed Gene) and its protein product
    Patent number: 6727079
    Abstract: Nucleic acids that encode novel polypeptides, designated in the present application as “BOG” (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-&bgr;1 as well as in primary liver tumors. Compositions including BOG chimeras, nucleic acids encoding BOG and antibodies to BOG are also provided. Methods of using BOG to modulate pRb-protein interactions and to alter cellular phenotype are further provided.
    Type: Grant
    Filed: August 11, 2000
    Date of Patent: April 27, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Snorri S. Thorgeirsson, Joseph T. Woitach, Minghuang Zhang