Patents by Inventor Joseph TAFT

Joseph TAFT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR PREDICTING KINASE INHIBITOR RESISTANCE
    Publication number: 20220380832
    Abstract: Provided are methods for the identification of mutant kinases that are resistant to inhibition by a kinase inhibitor. In some embodiments, the methods may be used to assess a test compound or kinase inhibitor for the risk of the development of resistance in vivo, e.g., during clinical administration to treat a disease such as a cancer.
    Type: Application
    Filed: January 3, 2022
    Publication date: December 1, 2022
    Applicant: Research Development Foundation
    Inventors: Brent IVERSON, George GEORGIOU, Joseph DESAUTELLE, Joseph TAFT
  • Methods for predicting kinase inhibitor resistance
    Patent number: 11236380
    Abstract: Provided are methods for the identification of mutant kinases that are resistant to inhibition by a kinase inhibitor. In some embodiments, the methods may be used to assess a test compound or kinase inhibitor for the risk of the development of resistance in vivo, e.g., during clinical administration to treat a disease such as a cancer.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: February 1, 2022
    Assignee: Research Development Foundation
    Inventors: Brent Iverson, George Georgiou, Joseph Desautelle, Joseph Taft
  • Methods for generating engineered enzymes
    Patent number: 10900059
    Abstract: Provided are improved methods for identifying the substrate recognition specificity or activity of a protease, convertase (sortase), or kinase. In some embodiments, methods are provided for identifying the endogenous protease or convertase cleaving patterns (e.g., “cleaveOme”) inside the secretory pathway of a living cell. Select embodiments involve aspects of yeast endoplasmic reticulum sequestration screening and next generation sequencing. Methods of producing polypeptides in Kex2 knockout yeast are also provided.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: January 26, 2021
    Assignee: Research Development Foundation
    Inventors: Brent Iverson, Peter Marek, Joseph Taft
  • METHODS FOR PREDICTING KINASE INHIBITOR RESISTANCE
    Publication number: 20190161787
    Abstract: Provided are methods for the identification of mutant kinases that are resistant to inhibition by a kinase inhibitor. In some embodiments, the methods may be used to assess a test compound or kinase inhibitor for the risk of the development of resistance in vivo, e.g., during clinical administration to treat a disease such as a cancer.
    Type: Application
    Filed: November 2, 2018
    Publication date: May 30, 2019
    Inventors: Brent Iverson, George Georgiou, Joseph Desautelle, Joseph Taft
  • Compositions and methods related to recombinant antibodies to histone posttranslational modifications
    Patent number: 10208110
    Abstract: Embodiments concern compositions and methods involving recombinant antibodies to histone post-translational modifications. The invention provides compositions and methods for histone methyltransferase assays. In certain embodiments, the compositions and methods involve a recombinant antibody that binds histone H3 fragment harboring biomarkers such as H3K9me3 mark, H3K4me3 mark, H3K36me3 mark, H3K27me3, H3K9me3 and H3S10phos or a recombinant antibody that binds histone H4 fragment harboring H4K20me3 mark.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: February 19, 2019
    Assignee: The University of Chicago
    Inventors: Takamitsu Hattori, Shohei Koide, Joseph Taft, Akiko Koide
  • METHODS FOR GENERATING ENGINEERED ENZYMES
    Publication number: 20170233781
    Abstract: Provided are improved methods for identifying the substrate recognition specificity or activity of a protease, convertase (sortase), or kinase. In some embodiments, methods are provided for identifying the endogenous protease or convertase cleaving patterns (e.g., “cleaveOme”) inside the secretory pathway of a living cell. Select embodiments involve aspects of yeast endoplasmic reticulum sequestration screening and next generation sequencing. Methods of producing polypeptides in Kex2 knockout yeast are also provided.
    Type: Application
    Filed: October 14, 2015
    Publication date: August 17, 2017
    Inventors: Brent IVERSON, Peter MAREK, Joseph TAFT