Abstract: Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.

Abstract: A method for use in additive manufacturing of a three-dimensional workpiece is described. The method includes depositing material onto a substrate to form a shape of the workpiece in accordance with an additive manufacturing process; determining a thermal characteristic of at least a portion of the workpiece during the additive manufacturing process; determining that the thermal characteristic of at least the portion exceeds a threshold associated with the portion; adjusting a cooling parameter of a cooling flow to be applied to the workpiece responsive to determining that the thermal characteristic of at least the portion exceeds the threshold associated with the portion; and applying the cooling flow with the adjusted cooling parameter to at least the portion of the workpiece.

Abstract: An actuator for a control surface is provided. The actuator includes a frame, an electric motor, an epicyclic gear, a power-off brake, a power-on brake, and a unidirectional bearing. A sun gear is operably coupled to an output of the motor. A carrier is couplable to the control surface such that rotation of the carrier in a first direction transitions the control surface toward the deployed position and rotation of the carrier in a second direction transitions the control surface toward the stowed position. The power-off brake couples to the sun gear to ground the sun gear when deenergized. The power-on brake couples to the ring gear to ground the ring gear when energized. When the power-on brake is deenergized, the unidirectional bearing permits the ring gear to rotate in the second direction and prevents the ring gear from rotating in the first direction.

Abstract: Disclosed are gaming systems, methods and machines that may include one or more notched display screens. The notched display screens are defined by a non-rectangular shape. One or more portions of the display screen is removed, such that a variety of shapes can result from one or more cuts in the screen. In some examples, two or more notched display screens are arranged to provide a common and/or coordinated display. In some examples, a void from the removed portions can be used to present a feature, such as a mechanical reel.

Abstract: An actuator for a control surface is provided. The actuator includes a frame, an electric motor, an epicyclic gear, a power-off brake, a power-on brake, and a unidirectional bearing. A sun gear is operably coupled to an output of the motor. A carrier is couplable to the control surface such that rotation of the carrier in a first direction transitions the control surface toward the deployed position and rotation of the carrier in a second direction transitions the control surface toward the stowed position. The power-off brake couples to the sun gear to ground the sun gear when deenergized. The power-on brake couples to the ring gear to ground the ring gear when energized. When the power-on brake is deenergized, the unidirectional bearing permits the ring gear to rotate in the second direction and prevents the ring gear from rotating in the first direction.

Abstract: The subject of this disclosure includes an ablation system for visually supporting a tissue ablation procedure, including a display comprising a user interface; and at least one processor in communication with the display, the at least one processor configured to control one or more of a plurality of electrodes of a radiofrequency balloon catheter to ablate organ tissues of one or more targeted pulmonary veins; determine a characteristic, based on ablation parameters of the radiofrequency balloon catheter, of pulmonary vein isolation (PVI) success rate; and present, on the display, visual information corresponding to each electrode for an indication, based on the characteristic, for PVI success rate.

Abstract: An electronic gaming system is provided. The electronic gaming system may include an electronic gaming device including a scanner and a display device, at least one memory with instructions stored thereon, and at least one processor in communication with the at least one memory and the electronic gaming device, wherein the instructions, when executed by the at least one processor, may cause the at least one processor to (1) cause the scanner to read a player code displayed by a mobile device of a player; (2) identify a user identifier associated with the player based on the player code; (3) after identifying the user identifier, receive gameplay information from the electronic gaming device; and (4) store the received gameplay information in the at least one memory in association with the identified user identifier.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: A communal gaming system provides a communal game to players of electronic gaming devices. The system includes a plurality of EGMs, each EGM includes a trigger condition identifying when the player is awarded participation in the communal game. The system also includes a communal game display configured to display a communal game play area. The system (a) begins a game cycle for a game instance of the communal game; (b) receives, from a first device and in response to detecting the trigger condition, a communal participation trigger message; (c) awards a participation entry in the game cycle to the player; (d) transmits, to the first device, a participation award message indicating successfully entry of the player in the game cycle; (e) conducts the communal game, thereby generating an award outcome of the communal game for the player; and (f) awards the player based on the generated award outcome.

Abstract: An information handling system includes a printed circuit board, a z-axis compression connector, and a compression attached memory module (CAMM). The compression connector coupled receives a first memory channel and a second memory channel from the PCB. The CAMM receives the first memory channel and the second memory channel from the first compression connector. The CAMM is configured to provide memory transaction on only the first memory channel.

Abstract: Apparatus for medical treatment, consisting of a probe and a processor. The probe has an insertion tube having a distal end configured for insertion into a body cavity of a living subject, and a basket assembly having multiple resilient spines coupled to the distal end of the insertion tube and joined together in a predefined form when the basket assembly is unconstrained by external forces. The probe also has a force sensor configured to output an indication of a force exerted on the basket assembly within the body cavity. The processor is configured to receive the indication of the force, to compute a constrained form of the basket assembly, different from the predefined form, responsively to the force, and to render to a display a graphical image representing the constrained form of the basket assembly.

Abstract: Disclosed is an elevator system having an elevator entryway, the elevator entryway including: a first door, which is an elevator door, a first controller operationally connected to the first door for opening and closing the first door to provide access to an elevator, wherein when the first door is closing: the first controller monitors for first instructions over a frequency applicable to light detection and ranging (LIDAR) and/or a radio detection and ranging (RADAR), and upon receiving the first instructions, the first controller executes the first instructions.

Abstract: Systems, methods, and computer readable media for providing a multiplayer game to players of a plurality of electronic gaming machines are described. When executed by a at least one processor, stored instructions cause the at least one processor to (i) cause to be displayed, on a multiplayer game display, a group metamorphic game element configured to interact with each of the plurality of electronic gaming machines, (ii) activate, during a first game play on a first electronic gaming machine, a multiplayer feature, (iii) cause the group metamorphic game element to transition one of the communal game elements from the multiplayer game display to an individual metamorphic game element associated with the first electronic gaming machine, and (iv) based on the transitioned communal game element, apply the activated multiplayer feature to a first game play on the first electronic gaming machine.

Abstract: The present disclosure relates to bonding a first substrate together a second substrate with adhesives that are substantially tackifier free. A layer of substantially tackifier free adhesive may be applied to a first surface of the second substrate to define an adherence zone, and the first substrate is positioned on the adherence zone of the second substrate to form a laminate. The first and second substrates are pressed against each other in the adherence zone to force the substantially tackifier free adhesive to penetrate into the first and second substrates. A first portion of the layer of the adhesive penetrates into the first substrate and a second portion of the layer of the adhesive penetrates into the second substrate. A central portion of the layer of the adhesive between the first and second portions separates the second surface of the first substrate from the first surface of the second substrate.

Abstract: A system includes a medical probe and a processor. The medical probe includes a shaft for insertion into a cavity of an organ of a patient; an expandable assembly fitted at a distal end of the shaft, wherein the expandable assembly has elastic properties; a position sensing element mounted on the distal end of the shaft; and at least one distal position sensing element on a distal end of the expandable assembly. The processor senses relative location of each of the at least one distal position sensing element and the proximal position sensing element; determines deflection of the expandable assembly based on the relative location; relates the deflection to the contact force applied on the expandable assembly; and provides an indication of the contact force on a display.

Abstract: The present invention provides methods and compositions for sensitizing glioma cells to immunotherapy by contacting the cells with a Sec61 complex inhibitor.

Abstract: A medical probe for insertion has at least one distal electrode coupled to an energy source to apply energy to tissue inside the body. A plurality of apertures are formed in the electrode. A fluid-directing assembly is disposed in the distal section of the probe having an axial channel that is in fluid communication with at least one trans-axial channel disposed at right angles to the axial channel and leading to an exterior of the assembly. A blocking terminus is disposed forward of the at least one trans-axial channel that prevents irrigation fluid from flowing axially in a forward direction so that the fluid flows outwardly into the lumen of the electrode in at least one trans-axial direction.

Abstract: A pressure monitor device includes a console having a display monitor and a plurality of input and output ports. An extension cable includes a distal end having a connector that connects to at least one of the plurality of input and output ports formed on the console, and a proximal end having a junction. A sensor mechanism includes a sensor mechanism reference cable for coupling the sensor mechanism to the junction of the extension cable. An electrical reference system includes a reference electrode and a patient reference cable having a proximal end communicatively coupled to the extension cable and a distal end communicatively coupled to the reference electrode. The reference electrode establishes a reference electrical potential of an external environment to electrically equilibrate the pressure monitor device.

Abstract: Systems and methods of the various embodiments may provide metal electrodes for electrochemical cells. In various embodiments, the electrodes may comprise iron. Various methods may enable achieving high surface area with low cost for production of metal electrodes, such as iron electrodes.