Abstract: Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a 10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 10Fn3 drug conjugates are also provided.

Abstract: The present application relates to antibodies specifically binding to immunoglobulin-like transcript 4 (ILT4), which is also known as LILRB2, LIR2, MIR10, and CD85d, and corresponding nucleic acids, host cells, compositions, and uses. In some embodiments, the antibodies bind specifically to human ILT4, but do not significantly bind to ILT2, ILT3, or ILT5, or to other members of the LILRA or LILRB families.

Abstract: Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a 10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 10Fn3 drug conjugates are also provided.

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.

Abstract: The present application relates to antibodies specifically binding to immunoglobulin-like transcript 4 (ILT4), which is also known as LILRB2, LIR2, MIR10, and CD85d, and corresponding nucleic acids, host cells, compositions, and uses. In some embodiments, the antibodies bind specifically to human ILT4, but do not significantly bind to ILT2, ILT3, or ILT5, or to other members of the LILRA or LILRB families.

Abstract: A window covering apparatus is disclosed, along with a method of using the same. The apparatus may include an upper board component and a lower board component, which are releasably held by central mounts. The upper board and lower board components can be arranged in a fully open shutter state, a half open shutter state, or a fully closed shutter state. The central mounts are positioned near flush to one or more outside or surrounding window surfaces in order to block light transmission. In one embodiment, the upper board and/or the lower board component may incorporate decorative elements and a gapless seam between the upper board and lower board components.

Abstract: A window covering apparatus is disclosed, along with a method of using the same. The apparatus may include an upper board component and a lower board component, which are releasably held by central mounts. The upper board and lower board components can be arranged in a fully open shutter state, a half open shutter state, or a fully closed shutter state. The central mounts are positioned near flush to one or more outside or surrounding window surfaces in order to block light transmission. In one embodiment, the upper board and/or the lower board component may incorporate decorative elements and a gapless seam between the upper board and lower board components.

Abstract: Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a 10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 10Fn3 drug conjugates are also provided.

Abstract: The present application relates to antibodies specifically binding to immunoglobulin-like transcript 4 (ILT4), which is also known as LILRB2, LIR2, MIR10, and CD85d, and corresponding nucleic acids, host cells, compositions, and uses. In some embodiments, the antibodies bind specifically to human ILT4, but do not significantly bind to ILT2, ILT3, or ILT5, or to other members of the LILRA or LILRB families.

Abstract: Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a 10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 10Fn3 drug conjugates are also provided.

Abstract: Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a 10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 10Fn3 drug conjugates are also provided.

Abstract: An apparatus and methods are disclosed for use by organizations that have PBXs at a plurality of sites. The invention pertains to cell phone calls from an to his or her “home” private branch exchange. For example, an employee who works at the Chicago branch office might call the Chicago office's PBX to invoke a feature such as setting up call forwarding, retrieving voice mail, etc. In the illustrative embodiment, such calls might be automatically and transparently directed to another PBX when it is advantageous to do so (e.g., for the purposes of security, reducing toll charges, because of unavailability of a particular PBX, etc.) Factors that might be used to determine whether to re-direct a call and to which PBX to re-direct a call include the day and time of the call, the network that the cell phone is currently connected to, etc.

Abstract: A method and apparatus are disclosed for routing calls over an organization's private network of private branch exchanges. In particular, when a member of the organization (e.g., an employee, etc.) places a call from his or her affiliated off-premises telecommunications terminal (e.g., cell phone, etc.), the call is automatically routed to its destination through at least a portion of the private network of private branch exchanges when doing so reduces the cost of the call. In the illustrative embodiment, the call routing is performed automatically and transparently via software on the affiliated terminals (i.e., employees' cell phones) and on the organization's private branch exchanges.

Abstract: A system and method are disclosed that automatically provide a user profile to an emergency call center. The system includes a network having a user profile manager configured to manage communication between a telecommunications device and the emergency call center, wherein the user profile manager is configured to automatically transmit the user profile to the emergency call center in response to a predetermined event.

Abstract: The present invention provides a gas transfer apparatus designed for enhanced purging of a pigtail conduit and a process for effecting such purging. The apparatus comprises a surge chamber having a first end, a body and a second end, the first end in communication with the pigtail conduit. A body section of the surge chamber has a cross-section larger than the cross-section of the pigtail conduit. The second end is in communication with a vessel containing a gas source. The apparatus includes a purge gas source for delivery of a purge gas to the pigtail conduit whereby during an alternating cycle of pressurization of the pigtail conduit with the purge gas and depressurization, impurities can be removed from within the pigtail conduit.

Abstract: An embodiment of the disclosed method and apparatus relates to a system for detecting a rub in a turbomachine. The system comprises: a turbomachine; sensors monitoring turbomachine conditions; and an on site monitor in communication with the sensors, and loaded with instructions to implement a method for detecting a rub in the turbomachine. An embodiment of the disclosed method relates to a method for detecting a rub in a turbomachine, the method comprising: monitoring turbomachine conditions; and determining whether a rub is occurring. Another embodiment of the disclosed apparatus relates to a storage medium encoded with a machine-readable computer program code for detecting a rub in a turbomachine, the storage medium including instructions for causing a computer to implement a method. The method comprises: obtaining data indicating turbomachine conditions; and determining whether a rub is occurring.

Abstract: A hemorrhoid relief and anal hygiene device includes a pressure member for placement between opposing buttock surfaces in the natal cleft adjacent to the anus of the user. The pressure member has opposite side faces for each positioning against one of the opposing buttock surfaces of the user. The pressure member has a perimeter wall extending between the opposite side faces with first, second, and third sections. The first and second sections have inboard ends converging at a protruding crest for partial insertion in the anus. The first and second sections are concave for abutting opposite areas of the surface of the anus. The third section extends between outboard ends of the first and second sections. A second embodiment of the device includes a bulbous central portion having a substantially spherical shape and a pair of elongate side members extending outwardly from opposite sides of the central portion.

Abstract: A hemorrhoid relief and anal hygiene device is provided including a pressure member for placement between opposing buttock surfaces in the natal cleft adjacent to the anus of the user. The pressure member has opposite side faces for each positioning against one of the opposing buttock surfaces of the user. Each of the side faces of the pressure member is substantially planar. Each of the side faces of the pressure member lie in substantially parallel planes. The pressure member has a perimeter wall that extends between the opposite side faces. The perimeter wall has a first section, a second section, and a third section. The first and second sections of the perimeter wall has inboard ends converging at a protruding crest adapted for partial insertion in the anus of the user. The first and second sections are concave for abutting opposite areas of the surface of the anus. The third section extends between outboard ends of the first and second sections.