Abstract: A system with an integrated internal battery, a removable battery, and a power management integrated circuit. The power management integrated circuit is configured to provide power to the image capture device from the removable battery; provide power to the image capture device from the integrated internal battery when the removable battery is disconnected from the image capture device or the removable battery does not have a sufficient charge to drive the image capture device; and recharge the integrated internal battery before the removable battery until the integrated internal battery has a sufficient charge to power the image capture device. The power is continuously supplied to the image capture device from the integrated internal battery while the removable battery is disconnected from the image capture device or does not have sufficient power to drive the image capture device.

Abstract: Integrated multiple actuator electro-hydraulic systems as well as their methods of use are described. Depending on the particular application, the integrated electro-hydraulic systems may exhibit different frequency responses and/or may be integrated into a single combined unit.

Abstract: Provided herein are cyclic polypeptide compounds that can, e.g., bind specifically to human proprotein convertase subtilisin/kexin type 9 (PCSK9) and optionally also inhibit interaction between human PCSK9 and human low density lipoprotein receptor (LDLR), and pharmaceutical compositions comprising one or more of these compounds. Also provided are methods of reducing LDL cholesterol level in a subject in need thereof that include administering to the subject one or more of the cyclic polypeptide compounds or a pharmaceutical composition provided herein.

Abstract: A mount (coupler) is disclosed that is configured to connect an image capture device to an accessory. The mount includes a female component that is configured for connection to the accessory and which defines stops, and a male component that is configured for removable insertion into the female component. The male component includes: a body; arms that are supported by the body and which are configured for engagement with the stops to thereby connect the male component to the female component; and a power hub that is supported by the body and which is configured to receive a power cord along a longitudinal axis to thereby deliver power and/or data to the mount. The male component is configured for disconnection from the female component upon deflection of the arms beyond a threshold release distance that is less than a maximum transverse (e.g., horizontal) cross-sectional dimension defined by the power cord.

Abstract: A camera includes a housing that defines a camera housing cavity and a lens assembly partially disposed in the camera housing cavity. The lens assembly comprises a lens, a lens cover, and a lens cavity that is defined between the lens and the lens cover. The camera includes a fluid path that extends from the lens cavity, through the camera housing cavity, and to an external environment. The camera includes a seal that partially obstructs the fluid path and is configured to equalize a humidity in the lens cavity with a humidity in the external environment.

Abstract: An image head with a housing, an integrated sensor and lens assembly (ISLA), a port, and internal componentry. The housing has a front side; a rear side; a top side; and a bottom side. The ISLA extends from the front side and is configured to detect images. The port is located on the rear side that is configured to electrically connect the image head to a base when the image head is inserted into the base. The internal componentry includes: a first microphone located within the front side below the ISLA; a second microphone located within the top side of the housing; a speaker located at the bottom side of the housing; a printed circuit board in communication with the integrated sensor of the ISLA; and a memory located on the printed circuit board and configured to store the images.

Abstract: A method and system for continuously supplying power to an image capture device during an image capture session are disclosed. The image capture device includes an integrated internal battery located internal to the image capture device and a removable battery connected to the image capture device. Power is provided to the image capture device from the removable battery. When the removable battery is disconnected from the image capture device, power is provided to the image capture device from the integrated internal battery. When a new removable battery is connected to the image capture device, power is provided to the image capture device from the new removable battery. Power is continuously supplied to the image capture device from the integrated internal battery while the removable battery is disconnected and replaced with the new removable battery.

Abstract: An image capture device is described that includes a body; a mounting structure that is connected to the body; an integrated sensor-lens assembly (ISLA) that defines an optical axis and extends through the body and the mounting structure; and an accessory that is releasably connectable to the mounting structure via rotation through a range of motion less than approximately 90 degrees. The mounting structure and the accessory include corresponding angled bearing surfaces that are configured for engagement such that rotation of the accessory relative to the mounting structure creates a bearing effect that displaces the accessory along the optical axis to thereby reduce any axial force required during connection and disconnection of the accessory.

Abstract: An image capture device is disclosed that includes a body and a door assembly that is configured for removable connection to the body. The door assembly includes a door body; a locking mechanism that is slidable in relation to the door body between a locked position and an unlocked position; and at least one biasing member that is configured for engagement (contact) with the door body and the locking mechanism to automatically move the locking mechanism into the locked position upon closure of the door assembly.

Abstract: An image head with a housing, an integrated sensor and lens assembly (ISLA), a port, and internal componentry. The housing has a front side; a rear side; a top side; and a bottom side. The ISLA extends from the front side and is configured to detect images. The port is located on the rear side that is configured to electrically connect the image head to a base when the image head is inserted into the base. The internal componentry includes: a first microphone located within the front side below the ISLA; a second microphone located within the top side of the housing; a speaker located at the bottom side of the housing; a printed circuit board in communication with the integrated sensor of the ISLA; and a memory located on the printed circuit board and configured to store the images.

Abstract: An image capture device includes a housing and a lens cavity comprising an external lens that separates the lens cavity from an exterior environment. The lens cavity is connected with an inside of the housing. The image capture device includes a door positioned on the housing that opens the inside of the housing to the exterior environment. The image capture device includes a vent positioned on housing so that moisture can be vented from housing and the lens cavity to the exterior environment.

Abstract: The image capture device includes a receptacle defined within a housing and an optic system that is removably connect with the receptacle and to generate thermal energy. The image capture device includes a heatsink positioned at a base of the receptacle. The heatsink includes an inner support positioned within the housing and an outer support in thermal communication with the optic system and the inner support. The heatsink further includes a gasket integrated with the receptacle to form a watertight seal, sandwiched between portions of the inner and outer supports, and flexibly retaining a physical connection between the optic system and the outer support.

Abstract: An image capture device is described that includes a body; a mounting structure that is connected to the body; an integrated sensor-lens assembly (ISLA) that defines an optical axis and extends through the body and the mounting structure; and an accessory that is releasably connectable to the mounting structure via rotation through a range of motion less than approximately 90 degrees. The mounting structure and the accessory include corresponding angled bearing surfaces that are configured for engagement such that rotation of the accessory relative to the mounting structure creates a bearing effect that displaces the accessory along the optical axis to thereby reduce any axial force required during connection and disconnection of the accessory.

Abstract: An image capture device (100) is disclosed that includes a body (102) and a door assembly (400) that is configured for removable connection to the body (102). The door assembly (400) includes a door body (500); a locking mechanism (600) that is slidable in relation to the door body (500) between a locked position and an unlocked position; and at least one biasing member (700) that is configured for engagement (contact) with the door body (500) and the locking mechanism (600) to automatically move the locking mechanism (600) into the locked position upon closure of the door assembly (400).

Abstract: Provided herein are cyclic polypeptide compounds that can, e.g., bind specifically to human proprotein convertase subtilisin/kexin type 9 (PCSK9) and optionally also inhibit interaction between human PCSK9 and human low density lipoprotein receptor (LDLR), and pharmaceutical compositions comprising one or more of these compounds. Also provided are methods of reducing LDL cholesterol level in a subject in need thereof that include administering to the subject one or more of the cyclic polypeptide compounds or a pharmaceutical composition provided herein.

Abstract: An image head including a housing, side rails, a port, and internal componentry. The housing includes a first side and a second side located opposite the second side. The side rails are located on or within the first side, the second side, or both and the side rails are configured to provide sliding directional control of the image head when connecting to a base. The port is configured to electrically connect the image head to the base. The internal componentry includes a printed circuit board; an integrated lens and sensor assembly (ISLA) configured to generate an image; and memory located on the printed circuit board configured to store the image.

Abstract: An image head including a housing, side rails, a port, and internal componentry. The housing includes a first side and a second side located opposite the second side. The side rails are located on or within the first side, the second side, or both and the side rails are configured to provide sliding directional control of the image head when connecting to a base. The port is configured to electrically connect the image head to the base. The internal componentry includes a printed circuit board; an integrated lens and sensor assembly (ISLA) configured to generate an image; and memory located on the printed circuit board configured to store the image.

Abstract: An image capture device is described that includes a body; a mounting structure that is connected to the body; an integrated sensor-lens assembly (ISLA) that defines an optical axis and extends through the body and the mounting structure; and an accessory that is releasably connectable to the mounting structure via rotation through a range of motion less than approximately 90 degrees. The mounting structure and the accessory include corresponding angled bearing surfaces that are configured for engagement such that rotation of the accessory relative to the mounting structure creates a bearing effect that displaces the accessory along the optical axis to thereby reduce any axial force required during connection and disconnection of the accessory.

Abstract: A method for making an article for application to the human body. Data from measurement of pressures across an area of a person's body is obtained, which is then corresponded to a two-dimensional pressure map of a model of an article for application to that body area and identifying pressure-point locations and a pressure value for identified pressure-point location within the pressure map. Each different pressure value has a compression unit structure corresponding to that pressure value. The article is formed by generating the assigned respective structures in an integrated one-piece construct through layerwise build up in an additive manufacture system, where the build up includes a process that forms a joinder in an interface between adjacent contiguous structures which differ in geometry from one another so as to bond those contiguous structures together across the interface.

Abstract: Disclosed are compounds of Formula A, or a pharmaceutically acceptable salt thereof: where A, X, R1, and R2 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.