Patents by Inventor Joseph W. Marsico, Jr.

Joseph W. Marsico, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-imidazolylalkyl-, triazolylalkyl-, pyridinylalkyl-1,2,3-benzotriazin-4(3H)-ones and derivatives thereof
    Patent number: 4680293
    Abstract: Novel 3-heteroarylalkyl-1,2,3-benzotriazin-4(3H)-ones, having the structural formula: ##STR1## wherein A is a divalent moiety of the formula: ##STR2## wherein n is an integer from 3 to 10, inclusive; R.sub.1 and R.sub.2 may be the same or different and may be selected from the group consisting of hydrogen, halogen, trifluoromethyl, alkoxy having from one to four carbon atoms, alkyl having from one to four carbon atoms, nitro and amino; wherein Heteroaryl is ##STR3## wherein R.sub.3 and R.sub.4 may be hydrogen, alkyl having from one to four carbon atoms or phenyl and X is CH or N; together with the pharmaceutically acceptable salts thereof; processes for their preparation and their use in treating prostaglandin-related vascular disorders including ischemic heart disease, transient ischemic attack, thrombosis, migraine and hypertension.
    Type: Grant
    Filed: March 3, 1986
    Date of Patent: July 14, 1987
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Andrew S. Tomcufcik, Joseph W. Marsico, Jr.
  • N-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)-alkyl]benzenesulfonamides and thromboxane synthetase/antihypertensive compositions
    Patent number: 4610981
    Abstract: This invention concerns novel N-[(1H-imidazol-1-yl), (1H-1,2,4-triazol-1-yl) and (3-pyridyl)alkyl]benzenesulfonamides which are useful as inhibitors of thromboxane synthetase enzyme and/or as antihypertensive agents.
    Type: Grant
    Filed: February 11, 1985
    Date of Patent: September 9, 1986
    Assignee: American Cyanamid Company
    Inventors: Joseph W. Marsico, Jr., William B. Wright, Jr.
  • N-(Substituted phenyl)-N'-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]ureas
    Patent number: 4576957
    Abstract: N-(Substituted phenyl)-N'-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]ureas which are inhibitors of thromboxane synthetase enzyme.
    Type: Grant
    Filed: July 5, 1984
    Date of Patent: March 18, 1986
    Assignee: American Cyanamid Company
    Inventors: Joseph W. Marsico, Jr., William B. Wright, Jr., Jeffery B. Press
  • 3-[(.alpha.-Substituted-benzyl]-2,3,dihydr othiazolo[3,2-a][1,3]diazacyclan-3-ol derivatives
    Patent number: 4393004
    Abstract: This disclosure describes certain novel 3-(.alpha.-substituted-benzyl)-2,3-dihydrothiazolo[3,2-a][1,3]diazacyclan- 3-ols which are useful as diuretic agents.
    Type: Grant
    Filed: January 29, 1982
    Date of Patent: July 12, 1983
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, William B. Wright, Jr., Joseph W. Marsico, Jr.
  • Substituted 2-alkylimino-3-alkyl-4-benzhydryl-4-thiazolidinols
    Patent number: 4377589
    Abstract: This disclosure describes substituted 2-alkylimino-3-alkyl-4-benzhydryl-4-thiazolidinols which are useful as diuretic agents.
    Type: Grant
    Filed: April 9, 1981
    Date of Patent: March 22, 1983
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, William B. Wright, Jr., Joseph W. Marsico, Jr.
  • N'-(2, 6-Dichloro-4-(substituted-benzylamino)phenyl)-N,N-dimethyl-formamidines
    Patent number: 4368335
    Abstract: This disclosure describes novel N'-[2,6-dichloro-4-(substituted-benzylamino)phenyl]-N,N-dimethyl-formamidi nes which possess activity as hypotensive agents and as diuretics.
    Type: Grant
    Filed: November 25, 1981
    Date of Patent: January 11, 1983
    Assignee: American Cyanamid Company
    Inventors: Walter E. Meyer, Andrew S. Tomcufcik, Joseph W. Marsico, Jr.
  • N'-[2,6-Dichloro-4-(substituted-benzylideneamino)phenyl]-N,N-d imethylformamidines
    Patent number: 4360466
    Abstract: This disclosure describes novel N'-[2,6-dichloro-4-(substituted-benzylideneamino)phenyl]-N,N-dimethylforma midines which possess activity as hypotensive agents and as diuretics.
    Type: Grant
    Filed: November 25, 1981
    Date of Patent: November 23, 1982
    Assignee: American Cyanamid Company
    Inventors: Walter E. Meyer, Andrew S. Tomcufcik, Joseph W. Marsico, Jr.
  • 2,3-Disubstituted-thiazolo[3,2-a]pyrimidines
    Patent number: 4347248
    Abstract: This disclosure describes 2,3-disubstituted-thiazolo[3,2-a]pyrimidines which are useful as diuretic agents.
    Type: Grant
    Filed: March 23, 1981
    Date of Patent: August 31, 1982
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Andrew S. Tomcufcik, Joseph W. Marsico, Jr.
  • 2,3-Disubstituted-2,3,5,6,7,8-hex ahydro-thiazolo[3,2-a]-[1,3]diazepin-3-ols
    Patent number: 4344954
    Abstract: This disclosure describes certain novel 2,3-disubstituted-2,3,5,6,7,8-hexahydro-thiazolo[3,2-][1,3]diazepin-3-ols which are useful as diuretic agents.
    Type: Grant
    Filed: July 9, 1980
    Date of Patent: August 17, 1982
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, William B. Wright, Jr., Joseph W. Marsico, Jr.
  • 3-(.alpha.-Substituted-benzyl)-2,3-dihydrothiazolo [3,2-a][1,3]diazacyclan-3-ol derivatives
    Patent number: 4340734
    Abstract: This disclosure describes certain novel 3-(.alpha.-substituted-benzyl)-2,3-dihydrothiazolo[3,2-a][1,3]diazacyclan- 3-ols which are useful as diuretic agents.
    Type: Grant
    Filed: November 14, 1980
    Date of Patent: July 20, 1982
    Assignee: American Cyanamid Company
    Inventors: Andrews S. Tomcufcik, William B. Wright, Jr., Joseph W. Marsico, Jr.
  • 2,3-Disubstituted-2,3,6,7,8,9-hexahydro-5H-thiazolo[3,2 -a]-[1,3]diazocin-3-ols
    Patent number: 4283334
    Abstract: 2,3-Disubstituted-2,3,6,7,8,9-hexahydro-5H-thiazolo[3,2-a]-[1,3]diazocin-3- ols which are new compounds useful as diuretic agents.
    Type: Grant
    Filed: December 5, 1979
    Date of Patent: August 11, 1981
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, William B. Wright, Jr., Joseph W. Marsico, Jr.
  • Heterocyclic substituted benzylideneaminoguanidines
    Patent number: 4154947
    Abstract: This disclosure describes novel substituted benzylideneaminoguanidines useful as anti-hypertensive agents and as diuretics.
    Type: Grant
    Filed: March 13, 1978
    Date of Patent: May 15, 1979
    Assignee: American Cyanamid Company
    Inventors: Leon Goldman, Joseph W. Marsico, Jr.