Patents by Inventor Joseph W. Ricigliano

Joseph W. Ricigliano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA construct for immunization or gene therapy
    Patent number: 6310196
    Abstract: The present invention is directed to a DNA construct which is useful for immunization or gene therapy. The construct of the invention comprises muscle specific regulatory elements, such as a promoter or a promoter and one or more enhancer elements, and a DNA sequence under control of the muscle specific regulatory elements. Several DNA sequences may be incorporated into the DNA construct. In one embodiment, the DNA sequence codes for an antigen, antigenic determinant or an epitope of an antigen. In a second embodiment, the DNA sequence is a normal muscle gene which is effected in a muscle disease. In a third embodiment, the DNA sequence is an antisense for blocking an abnormal muscle gene. In a fourth embodiment, the DNA sequence codes for a protein which circulates in the mammalian blood or lymphatic systems.
    Type: Grant
    Filed: July 20, 1998
    Date of Patent: October 30, 2001
    Inventors: Joseph W. Ricigliano, Barbara A. Araneo
  • DNA construct for immunization
    Patent number: 5795872
    Abstract: The present invention is directed to a DNA construct which is useful for immunization or gene therapy. The construct of the invention comprises muscle specific regulatory elements, such as a promoter or a promoter and one or more enhancer elements, and a DNA sequence under control of the muscle specific regulatory elements. Several DNA sequences may be incorporated into the DNA construct. In one embodiment, the DNA sequence codes for an antigen, antigenic determinant or an epitope of an antigen. In a second embodiment, the DNA sequence is a normal muscle gene which is effected in a muscle disease. In a third embodiment, the DNA sequence is an antisense for blocking an abnormal muscle gene. In a fourth embodiment, the DNA sequence codes for a protein which circulates in the mammalian blood or lymphatic systems.
    Type: Grant
    Filed: September 19, 1995
    Date of Patent: August 18, 1998
    Assignee: Pharmadigm, Inc.
    Inventors: Joseph W. Ricigliano, Barbara A. Araneo
  • Non-steroid and non-prostanoid inhibitors of steroid and prostaglandin transforming enzymes
    Patent number: 5439943
    Abstract: Compounds such as 1-(4'-nitrophenyl)-2-propen-1-ol are disclosed which are non-steroidal mechanism-based inactivators of rat liver 3.alpha.-hydroxysteroid dehydrogenase. The corresponding ketones are time dependent inactivators of cyclooxygenase (PGH.sub.2 -synthase).
    Type: Grant
    Filed: November 9, 1994
    Date of Patent: August 8, 1995
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Trevor M. Penning, Joseph W. Ricigliano
  • Non-steroid and non-prostanoid inhibitors of steroid and prostaglandin transforming enzymes
    Patent number: 5399790
    Abstract: Compounds such as 1-(4'-nitrophenyl)-2-propen-1-ol are disclosed which are non-steroidal mechanism-based inactivators of rat liver 3.alpha.-hydroxysteroid dehydrogenase. The corresponding ketones are time dependent inactivators of cyclooxygenase (PGH.sub.2 -synthase).
    Type: Grant
    Filed: August 30, 1993
    Date of Patent: March 21, 1995
    Assignee: Trustees of The University of Pennsylvania
    Inventors: Trevor M. Penning, Joseph W. Ricigliano
  • Non-steroid and non-prostanoid inhibitors of steroid and prostaglandin transfroming enzymes
    Patent number: 5258296
    Abstract: Compounds such as 1-(4'-nitrophenyl)-2-propen-1-ol are disclosed which are non-steroidal mechanism-based inactivators of rat liver 3.alpha.-hydroxysteroid dehydrogenase. The corresponding ketones are time dependent inactivators of cyclooxygenase (PGH.sub.2 -synthase).
    Type: Grant
    Filed: September 9, 1991
    Date of Patent: November 2, 1993
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Trevor M. Penning, Joseph W. Ricigliano
  • Non-steroidal suicide substrates of hydroxysteroid dehydrogenase
    Patent number: 5118621
    Abstract: Compounds, such as 1-(4'-nitrophenyl)-2-propen-1-ol, are disclosed which are highly selective non-steroidal suicide substrates for rat liver 3.alpha.-hydroxysteroid dehydrogenase.
    Type: Grant
    Filed: June 18, 1990
    Date of Patent: June 2, 1992
    Assignee: University of Pennsylvania
    Inventors: Trevor M. Penning, Joseph W. Ricigliano