Patents by Inventor Joseph W. Romano

Joseph W. Romano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic amides useful as protein modulators
    Patent number: 11970480
    Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.
    Type: Grant
    Filed: May 17, 2022
    Date of Patent: April 30, 2024
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Adam Kenneth Charnley, Michael G. Darcy, Jason W. Dodson, Xiaoyang Dong, Terry V. Hughes, Jianxing Kang, Lara Kathryn Leister, Yiqian Lian, Yue Li, John F. Mehlmann, Neysa Nevins, Joshi M. Ramanjulu, Joseph J. Romano, Gren Z. Wang, Guosen Ye, Daohua Zhang
  • Isothermal transcription based amplification assay for detection and quantification of guanylyl cyclase C
    Publication number: 20040018494
    Abstract: The present invention is directed to an isothermal transcription based assay for the detection and quantification of guanylyl cyclase C (GCC). The present invention is also directed to oligonucleotides for amplifying GCC RNA and probes for use in the detection and quantification of the amplification product. Finally, the present invention is directed to a method for detecting colon carcinoma, micrometastasis thereof and tumor recurrence by analyzing peripheral blood for the presence of GCC.
    Type: Application
    Filed: July 25, 2002
    Publication date: January 29, 2004
    Inventors: Roxanne N. Shurtliff, Eun Mi Lee, Joseph W. Romano
  • Isothermal transcription based assay for the detection and genotyping of dengue virus
    Patent number: 6333150
    Abstract: An isothermal transcription based amplification assay for dengue virus RNA uses primer combinations for sequences within the envelope gene or the 3′ non-coding region of the virus and a probe. Probes may be specific for a serotype of dengue virus.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: December 25, 2001
    Assignee: Akzo Nobel N.V.
    Inventors: Joseph W. Romano, Eun Mi Lee, Gregory J. Hurteau
  • Isothermal transcription based assay for the detection and quantification of chemokines rantes, MIP-1&agr; and MIP-1&bgr;
    Patent number: 6218154
    Abstract: An isothermal transcription based amplification assay for the detection or quantification of chemokine RNA uses primers and probes for sequences within the gene for RANTES, MIP-1&agr; and MIP-1 &bgr;. The quantitative system uses an internal control Q of a mutant version of each gene. Target specific primers and probes are also disclosed.
    Type: Grant
    Filed: July 16, 1999
    Date of Patent: April 17, 2001
    Assignee: Akzo Nobel N.V.
    Inventors: Joseph W. Romano, Roxanne Shurtliff, Kimberly G. Williams
  • CCR5 RNA transcription based amplification assay
    Patent number: 6204024
    Abstract: A method and a test kit for genotyping the CCR5 chemokine receptor. CCR5 transcript DNA is amplified using transcription based amplification. The amplification product is detected through the hybridization of appropriately labeled oligonucleotide wild type and mutant probes. In a liquid hybridization based ECL analysis, the mutant probe is a 16mer having the sequence 5′TCCATACATTAAAGAT3′ [SEQ ID NO:9]. The method and kit can be used to predict.
    Type: Grant
    Filed: September 12, 1997
    Date of Patent: March 20, 2001
    Assignee: Akzo Nobel N.V.
    Inventors: Joseph W. Romano, Eun Mi Lee
  • Isothermal transcription based assay for the detection and quantification of the chemokine rantes
    Patent number: 6121023
    Abstract: An isothermal transcription based amplification assay for the detection or quantification of chemokine RNA uses primers and probes for sequences within the gene for RANTES, MIP-l.alpha. and MIP-1 .beta.. The quantitative system uses an internal control Q of a mutant version of each gene. Target specific primers and probes are also disclosed.
    Type: Grant
    Filed: January 22, 1998
    Date of Patent: September 19, 2000
    Assignee: Akzo Nobel N.V.
    Inventors: Joseph W. Romano, Roxanne Shurtliff, Kimberly G. Williams
  • Isothermal transcription based assay for the detection and genotyping of dengue virus
    Patent number: 5968732
    Abstract: An isothermal transcription based amplification assay for dengue virus RNA uses primer combinations for sequences within the envelope gene or the 3' non-coding region of the virus and a probe. Probes may be specific for a serotype of dengue virus.
    Type: Grant
    Filed: December 31, 1997
    Date of Patent: October 19, 1999
    Assignee: Akzo Nobel, N.V.
    Inventors: Joseph W. Romano, Eun Mi Lee, Gregory J. Hurteau
  • Detection of human retrovirus infection
    Patent number: 5660979
    Abstract: A method for determining virus replication in human cells by human retrovirus using RNA amplification comprising detecting the hybridization of an RNA probe which specifically hybridizes with spliced RNA and not with genomic RNA. This method permits early detection of RNA replication resulting from primary infection without detecting non-replicating virus.
    Type: Grant
    Filed: November 4, 1994
    Date of Patent: August 26, 1997
    Assignee: Akzo Nobel N.V.
    Inventors: Joseph W. Romano, Ranajit Pal
  • Isothermal transcription based assay for the detection of HTLV I and HTLV II RNA
    Patent number: H1825
    Abstract: An isothermal transcription based amplification assay for the detection of HTLV I RNA uses primers and probes for sequences within the tax gene, the pol gene, or the gag gene. An isothermal transcription based amplification assay for the detection of HTLV II uses primers and probes for sequences within the tax gene. Target specific primers and probes are also disclosed.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: December 7, 1999
    Assignee: Akzo Nobel N.V.
    Inventors: Joseph W. Romano, Roxanne Shurtliff, Kimberly G. Williams