Patents by Inventor Joseph W. Wrin

Joseph W. Wrin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monoclonal antibodies that bind to and neutralize dimeric but not monomeric human M-CSF and methods of use thereof for detection of dimeric M-CSF
    Patent number: 5491065
    Abstract: Monoclonal antibodies that bind to an apparent conformational epitope associated with recombinant or native dimeric M-CSF with concomitant neutralization of biological activity, which monoclonal antibodies are substantially unreactive with biologically inactive forms of M-CSF including monomeric and chemically derivatized dimeric M-CSF, are described. Methods of using the antibodies in assays for detection of dimeric M-CSF are also described.
    Type: Grant
    Filed: November 19, 1993
    Date of Patent: February 13, 1996
    Assignee: Cetus Oncology Corporation
    Inventors: Robert F. Halenbeck, Kirston E. Koths, Joseph W. Wrin