Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3-butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.

Abstract: Benzodiazepine derivatives of formula (Ib) wherein: R1 is H or halo; Y is selected from O, S, SO, SO2 and NR; one or two of V, W and X is or are N or CH and the other one or two is or are CH; R2 is a group selected from C1-C6 alkyl, C1-C6 hydroxyalkyl, C1-C6 haloalkyl, halo, —OR, —NHR?, —SOmNR2, —SOmR, nitro, —CO2R, —CN, —CONR2, —NHCOR and —NR11R12; each R is independently H or C1-C6 alkyl; R11 and R12 are each independently H or C1-C6 alkyl; or R11 and R12 form, together with the N atom to which they are attached, either (a) a morpholine ring which is optionally bridged by a —CH2— group linking two ring carbon atoms that are positioned para to each other, or (b) a spiro group of the following formula (b): R? is C3-C6 cycloalkyl; m is 1 or 2; n is 0, 1 or 2; and each of R3 to R10 is independently selected from H, C1-C6 alkyl, halo, —OR, -NR2,—NHR?, —SOmNR2, —SOmR, nitro, —CO2R, —CN, —CONR2, —NHCOR, —NR13R 4 whereinR13 and R14 form, together with the N atom to which they are attached, a morpholine ring, and th

Abstract: Benzodiazepine derivatives of formula (Ie) wherein one R1 and R2 is a benzodiazepinyl-containing group of formula (II) in which R8 is H or halo; the other of R1 and R2 is a group Z selected from H, C3-C6 cycloalkyl, halo, —NHR9, benzyl, phenyl, 4- to 10-membered heterocyclyl and 4- to 10-membered heteroaryl, wherein phenyl, heterocyclyl and heteroaryl are unsubstituted or substituted by one or two substituents selected from 4- to 10-membered heterocyclyl which is unsubstituted or substituted by OR, and from C1-C6 alkyl, C1-C6 hydroxyalkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, halo, —OR, —(CH2)mOR, —NR2, —(CH2)mNR2, —NHR?, —SOmNR2, —SOmR, —SR, nitro, —CO2R, —CN, —CONR2, —NHCOR, —CH2NR10R11 and —NR10R11, in which each R is independently H or C1-C6 alkyl, R? is C3-C6 cycloalkyl and m is 1 or 2; R9 is selected from phenyl and 4- to 10-membered heteroaryl wherein phenyl and heteroaryl are unsubstituted or substituted by halo; R10 and R11 are each independently H or C1-C6 alkyl; or R10 and R11 form, together with the

Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3-butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.

Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3-butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.

Abstract: Benzodiazepine derivatives of formula (I): (I) wherein: each of R1 and R2 is independently H or halo; either (i) T is N, Z is C, —a— and —c— are bonds, and —b— and —d— are absent; or (ii) T is C, Z is N, —b— and —d— are bonds, and —a— and —c— are absent; each of R3 and R4 is independently halo, —OR6, —NR6R7—COR8, —C(O)OR8, —CON(R8)2 or —R6; R5 is H or halo; each of R6 and R7 is independently H or a group selected from C1-C-6 alkyl, C3-C10 cycloalkyl, C6-C10 aryl, 4- to 10-membered heterocyclyl and 4- to 10-membered heteroaryl, the group being unsubstituted or substituted; R8 is H or C1-C6 alkyl, each R8 being the same or different when two are present; n is 0 or 1; and one of V, W, X and Y is N or CH and the other three are CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

Abstract: Benzodiazepine derivatives of formula (I): (I) wherein: each of R1 and R2 is independently H or halo; either (i) T is N, Z is C, and are bonds, and and are absent; or (ii) T is C, Z is N, and are bonds, and and are absent; each of R3 and R4 is independently halo, —OR6, —NR6R7, —COR8, —C(O)OR8, —CON(R8)2 or —R6; R5 is H or halo; each of R6 and R7 is independently H or a group selected from C1-C6 alkyl, C3-C10 cycloalkyl, C6-C10 aryl, 4- to 10-membered heterocyclyl and 4- to 10-membered heteroaryl, the group being unsubstituted or substituted; R8 is H or C1-C6 alkyl, each R8 being the same or different when two are present; n is 0 or 1; and one of V, W, X and Y is N or CH and the other three are CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3-butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.

Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3-butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.

Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3-butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.

Abstract: Techniques are disclosed that allow for the detection, identification, direction finding, and geolocation of wireless emitters in a given multipath environment. For example, the techniques can be used to detect and identify a line of bearing (LOB) to an IEEE 802.11 emitter in a building or in an open field or along a roadside. Multiple LOBs computed from different geographic locations can be used to geolocate the target emitter. The techniques can be embodied, for instance, in a vehicle-based device that can survey the target environment, detect an IEEE 802.11 emitter and identify it by MAC address, and then determine various LOBs to that emitter to geolocate the emitter. In some cases, a sample array of response data from the target emitter is correlated to a plurality of calibrated arrays having known azimuths to determine the LOB to the target emitter.

Abstract: Techniques are disclosed that allow for the detection, identification, and direction finding of wireless emitters in a given multipath environment. For example, the techniques can be used to detect and identify a line of bearing (LOB) to an IEEE 802.11 emitter in a building or in an open field or along a roadside. In some cases, multiple LOBs can be used to geolocate the target emitter if so desired. The techniques can be embodied, for instance, in a handheld device that can survey the target environment, detect an IEEE 802.11 emitter and identify it by MAC address, and then precisely determine the LOB to that emitter. In some cases, a sample array of response data from the target emitter is correlated to a plurality of calibrated arrays having known azimuths to determine the LOB to the target emitter.

Abstract: Techniques are disclosed that allow for the detection, identification, and direction finding of wireless emitters in a given multipath environment. For example, the techniques can be used to detect and identify a line of bearing (LOB) to an IEEE 802.11 emitter in a building or in an open field or along a roadside. In some cases, multiple LOBs can be used to geolocate the target emitter if so desired. The techniques can be embodied, for instance, in a handheld device that can survey the target environment, detect an IEEE 802.11 emitter and identify it by MAC address, and then precisely determine the LOB to that emitter. In some cases, a sample array of response data from the target emitter is correlated to a plurality of calibrated arrays having known azimuths to determine the LOB to the target emitter.

Abstract: Techniques are disclosed that allow for the detection, identification, direction finding, and geolocation of wireless emitters in a given multipath environment. For example, the techniques can be used to detect and identify a line of bearing (LOB) to an IEEE 802.11 emitter in a building or in an open field or along a roadside. Multiple LOBs computed from different geographic locations can be used to geolocate the target emitter. The techniques can be embodied, for instance, in a vehicle-based device that can survey the target environment, detect an IEEE 802.11 emitter and identify it by MAC address, and then determine various LOBs to that emitter to geolocate the emitter. In some cases, a sample array of response data from the target emitter is correlated to a plurality of calibrated arrays having known azimuths to determine the LOB to the target emitter.

Abstract: Fractional motion estimation may be implemented by tagging sub-blocks of a first size. The sub-blocks may be located within blocks of picture data of a variety of different sizes, including the first size. The sub-blocks are tagged to link them to their motion vectors so that more efficient calculations may be implemented in some embodiments.

Abstract: The FANOXY PACK System concept of a technical textile strong enough to match the strength of steel to make a fabric oxygen tank is new. This in turn allows the fanny pack to become a viable oxygen supply carrying device to be used by millions of Chronic Obstructive Pulmonary Disease patients.

Abstract: A kit for outfitting the exterior surface of a vehicle is shown as being made up of a plurality of pressure-sensitive adhesive backed camouflage panels. Each of the panels may be adhered to a specific segment of the vehicle surface. The panels preferably include marginal strips that permit the panels to register with their associated segments of the vehicle. These marginal strips may also provide panel overlap portions to ensure complete surface coverage by the panels.

Abstract: A ceramic cutting blade includes a cutter portion having first and second side edges which converge at a distal acute angle to form a distal cutting tip and a cutting edge formed by first and second cutting faces oriented at a bevel angle. At least one of the cutting faces includes striations having a grain direction substantially perpendicular to the cutting edge, and these striations have a width of between 20 and 40 microns. The distal acute angle is preferably less than forty degrees, and the cutting tip is truncated along a straight line at an angle of truncation of at least forty degrees with respect to the cutting edge. The blade may be received by a handle or may be integrally molded with a handle portion.

Abstract: A device for assisting fish to circumnavigate obstacles such as dams is provided with a system of chambers within each of which is disposed an inclined, water permeable, floating screen movable up and down depending on the level of water in the chamber. The level of water is controlled by a system of strategically located gates and valves. The lowermost chamber is provided with a siphon-like arrangement assisting the draining of the chamber, without the need for a pump. The invention simplifies the overall arrangement and its operation.