Abstract: A scalpel handle includes a receiving member to receive a blade therethrough and a main portion coupled to the receiving member. The main portion has a number of indentations on both a first surface and a second surface thereof. The indentations are evenly spaced between one another and the number of indentations extends from a first end proximate the receiving member along a first length of the main portion across an entire width thereof. The first length is at least two-thirds of a second length of an entirety of the main portion. The width of the main portion is at least five times a maximum width of the receiving member. A thickness of the main portion is at least 2.5 times a maximum thickness of the receiving member. All outer surfaces of the main portion including the first surface and the second surface are convex in shape around edges thereof.

Abstract: Provided are methods for making highly dedifferentiated and stem-like human cells from human umbilical vein endothelial cells (HUVECs) ectopically expressing integrin ?3. Also provided are methods for making ectoderm, mesoderm, and endoderm cells from HUVECs ectopically expressing integrin ?3. Also provided are methods for making neural cells, or cells having neuronal-like morphology, from HUVECs ectopically expressing integrin ?3. Provided are methods for making cardiomyocytes, or cells having cardiomyocyte-like morphology, from HUVECs ectopically expressing integrin ?3. Provided are methods for the production of pluripotent stem cells comprising expressing integrin ?3 in primary human endothelial cells. In alternative embodiments, provided are methods for inducing ?v?3 clustering, and to accelerate or facilitate angiogenesis, tissue remodeling or repair, or wound healing, for example, to accelerate healing after an infarction.