Patents by Inventor Joseph Wedekind

Joseph Wedekind has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid binding compounds and methods of use
    Patent number: 9212205
    Abstract: The present invention relates to homo- and hetero-dimer compounds formed by a disulfide, sulfinyl thio, or olefin bond between two monomers. A method of making a homo- or hetero-dimer compound is also disclosed. The present invention also relates to monomer compounds capable of forming homo- or hetero-dimer compounds, as well as oligomers formed via linkage of one or more dimers. Also disclosed are methods of inhibiting the activity of target RNA molecules, particularly those having a secondary structure that include a stem or stem-loop formation. Dimer compounds capable of inhibiting the activity of an HIV-I RNA frameshifting stem-loop and a (CUG)n expanded repeat stem-loop are disclosed, as are methods of treating diseases associated with these target RNA molecules. The dimer compounds can also be used for selectively detecting presence of the target RNA molecule in a sample.
    Type: Grant
    Filed: July 28, 2008
    Date of Patent: December 15, 2015
    Assignee: University of Rochester
    Inventors: Benjamin L. Miller, Brian R. McNaughton, Peter C. Gareiss, Joseph Wedekind, Charles Thornton, Krzysztof Sobczak
  • NUCLEIC ACID BINDING COMPOUNDS AND METHODS OF USE
    Publication number: 20100266677
    Abstract: The present invention relates to homo- and hetero-dimer compounds formed by a disulfide, sulfinyl thio, or olefin bond between two monomers. A method of making a homo- or hetero-dimer compound is also disclosed. The present invention also relates to monomer compounds capable of forming homo- or hetero-dimer compounds, as well as oligomers formed via linkage of one or more dimers. Also disclosed are methods of inhibiting the activity of target RNA molecules, particularly those having a secondary structure that include a stem or stem-loop formation. Dimer compounds capable of inhibiting the activity of an HIV-I RNA frameshifting stem-loop and a (CUG)n expanded repeat stem-loop are disclosed, as are methods of treating diseases associated with these target RNA molecules. The dimer compounds can also be used for selectively detecting presence of the target RNA molecule in a sample.
    Type: Application
    Filed: July 28, 2008
    Publication date: October 21, 2010
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Benjamin L. Miller, Brian R. McNaughton, Peter C. Gareiss, Joseph Wedekind, Charles Thornton, Krzysztof Sobczak
  • PROTEIN TRANSDUCING DOMAIN/DEAMINASE CHIMERIC PROTEINS, RELATED COMPOUNDS, AND USES THEREOF
    Publication number: 20100160174
    Abstract: Disclosed are compositions for chimeric proteins comprising a protein transduction domain and a deaminase domain, mimetics or analog thereof, and uses of same.
    Type: Application
    Filed: July 27, 2009
    Publication date: June 24, 2010
    Applicant: University of Rochester Medical Center
    Inventors: Harold C. Smith, Mark P. Sowden, Stephen Dewhurst, Baek Kim, Joseph Wedekind
  • Cytidine deaminase activators, deoxycytidine deaminase activators, Vif antagonists, and methods of screening for molecules thereof
    Publication number: 20050112555
    Abstract: Disclosed are compounds that enhance RNA or DNA editing, as well as methods of using, identifying, and making such compounds. These compounds include Vif antagonists and cytidine deaminase inhibitors.
    Type: Application
    Filed: September 3, 2004
    Publication date: May 26, 2005
    Inventors: Harold Smith, Joseph Wedekind, Mark Sowden, Stephen Dewhurst, Baek Kim