Patents by Inventor Joseph Weinstock

Joseph Weinstock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6 -Halo-7,8-dimethoxy-1-(methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine s
    Patent number: 4321195
    Abstract: Certain 6-halo-7,8-dimethoxy-1-(methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine s and N-[2-(2-halo-3,4-dimethoxyphenyl)ethyl]-2-hydroxy-2-(methoxyphenyl)ethylam ines are intermediates for preparing 6-halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine s which are peripheral dopaminergic agents.
    Type: Grant
    Filed: May 23, 1979
    Date of Patent: March 23, 1982
    Assignee: SmithKline Corporation
    Inventor: Joseph Weinstock
  • 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
    Patent number: 4284556
    Abstract: A group of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines whose structures have amino, hydroxy substituents at the 7,8-positions of the benzazepine nucleus is disclosed. Novel intermediates and routes of synthesis used for preparing them are also described. The end products have pharmacodynamic activity.
    Type: Grant
    Filed: January 31, 1980
    Date of Patent: August 18, 1981
    Assignee: SmithKline Corporation
    Inventors: Kenneth G. Holden, Carl Kaiser, Joseph Weinstock
  • 6-Lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
    Patent number: 4265889
    Abstract: A series of 6-lower alkyl-7,8-dihydroxyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines having dopaminergic activity together with intermediates and processes for their preparation are disclosed.
    Type: Grant
    Filed: December 22, 1978
    Date of Patent: May 5, 1981
    Assignee: SmithKline Corporation
    Inventors: Charles K. Brush, Joseph Weinstock
  • 8-Hydro xy-6,7-(2-methyl-2,3-dihydrofuro)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzaz epines
    Patent number: 4255445
    Abstract: 8-Hydroxy-6,7-(2,3-dihydrofuro)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin es are prepared by a reaction sequence whose key is a dual cyclization forming the 3-benzazepine ring and fused thereto a dihydrofuran.
    Type: Grant
    Filed: March 7, 1980
    Date of Patent: March 10, 1981
    Assignee: SmithKline Corporation
    Inventors: Charles K. Brush, Joseph Weinstock
  • 6-Halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
    Patent number: 4255422
    Abstract: 7,8-Dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines having a halo substituent at the 6-position have potent dopaminergic activity. The 6-chloro congeners are most active.
    Type: Grant
    Filed: April 4, 1978
    Date of Patent: March 10, 1981
    Assignee: SmithKline Corporation
    Inventor: Joseph Weinstock
  • 4-(2-Aminoethyl)-7-hydroxy-2-methyl-2,3-dihydrobenzofurans
    Patent number: 4254140
    Abstract: 4-(2-Aminoethyl)-7-hydroxy-2-methyl-2,3-dihydrobenzofuran derivatives having dopaminergic activity are prepared by cyclizing a 2-allyl-3,4-dimethoxyphenethylamine such as by reacting the phenethylamine with hydrogen bromide.
    Type: Grant
    Filed: March 20, 1980
    Date of Patent: March 3, 1981
    Assignee: SmithKline Corporation
    Inventors: Charles K. Brush, Joseph Weinstock
  • 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydr oxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
    Patent number: 4251525
    Abstract: 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-be nzazepine derivatives are prepared by N-allylation of 7,8-dimethoxy-6-halo-1-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepi ne using an allyl halide in acetonitrile in the presence of base followed by O-demethylation. These compounds have a unique cardiovascular effect in that they are potent renal vasodilators and also induce bradycardia.
    Type: Grant
    Filed: May 25, 1979
    Date of Patent: February 17, 1981
    Assignee: SmithKline Corporation
    Inventor: Joseph Weinstock
  • 6-Halo-7,8-d ihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines
    Patent number: 4197297
    Abstract: 6-Halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines whose structures have a hydroxy group substituted on the 1-phenyl ring have potent and specific antihypertensive activity by means of their peripheral dopaminergic effect. The lead compound of the series is 6-chloro-7,8-dihydroxy-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepi ne methane sulfonate.
    Type: Grant
    Filed: March 13, 1978
    Date of Patent: April 8, 1980
    Assignee: SmithKline Corporation
    Inventor: Joseph Weinstock
  • 6-Halo-3-lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
    Patent number: 4192872
    Abstract: 6-Halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines whose structures have a lower alkyl substituted at the 3 or N-position have potent and often specific anti-Parkinsonism activity by means of their central dopaminergic effect. The lead compound of the series is 6-chloro-3-methyl-1-phenyl-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepi ne as the base or its salts such as the hydrochloride, hydrobromide or methane sulfonate.
    Type: Grant
    Filed: March 31, 1978
    Date of Patent: March 11, 1980
    Assignee: SmithKline Corporation
    Inventor: Joseph Weinstock
  • Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
    Patent number: 4171359
    Abstract: A group of 6,9-disubstituted-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepi nes have dopaminergic activity. Examples of leading species of the invention are 6,9-dichloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and 6,9-dichloro-7,8-dihydroxy-1-(p-hydroxy-phenyl)-2,3,4,5-tetrahydro-1H- 3-benzazepine in the form of an acid addition salt.
    Type: Grant
    Filed: April 12, 1978
    Date of Patent: October 16, 1979
    Assignee: SmithKline Corporation
    Inventor: Joseph Weinstock
  • 6-Carboxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds and use as dopaminergic agents
    Patent number: 4165372
    Abstract: A group of 1-phenyl-3-benzazepines with structures characterized by having a carboxy derived substituent at position 6 which are dopaminergic agents or are intermediates for preparing other dopaminergic agents. Particular illustrative species include 6-carbomethoxy-7,8-dihydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-ben zazepine, 6-carboxy-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and 6-carbomethoxy-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3- benzazepine.
    Type: Grant
    Filed: November 17, 1977
    Date of Patent: August 21, 1979
    Assignee: SmithKline Corporation
    Inventors: Charles K. Brush, Joseph Weinstock
  • Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
    Patent number: 4160765
    Abstract: The preparation of 6-bromo-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines is described by direct bromination of the nucleus.
    Type: Grant
    Filed: November 17, 1976
    Date of Patent: July 10, 1979
    Assignee: SmithKline Corporation
    Inventor: Joseph Weinstock
  • Substituted 1-alkylthiophenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
    Patent number: 4104379
    Abstract: A group of 1-phenyl-1H-3-benzazepines whose structures are characterized by having a functional thio containing group on the 1-phenyl moiety and which have pronounced peripheral and diminished central dopaminergic activity. This activity is manifested in an anti-hypertensive effect in humans. Particular species of this group include 6-chloro-7,8-dihydroxy-1-p-methylthiophenyl-2,3,4,5-tetrahydro-1H-3-benzaz epine and its derivatives which have dopaminergic activity.
    Type: Grant
    Filed: January 19, 1977
    Date of Patent: August 1, 1978
    Assignee: SmithKline Corporation
    Inventors: Gregory Gallagher, Jr., Francis R. Pfeiffer, Joseph Weinstock
  • Compositions comprising tetramic acid analogs of pulvinic acid and methods of combating arthritis
    Patent number: 3984559
    Abstract: Pharmaceutical compositions comprising tetramic acid analogs of pulvinic acid and methods of combating arthritis by administration of these compositions are disclosed.
    Type: Grant
    Filed: October 17, 1975
    Date of Patent: October 5, 1976
    Assignee: SmithKline Corporation
    Inventor: Joseph Weinstock
  • Anti-arthritic 1H-pyrimido-(5,4,3-kl)phenothiazine-1,3(2H)-diones and 1-thiones
    Patent number: 3962438
    Abstract: 1H-Pyrimido[5,4,3-kl]phenothiazine-1,3(2H)-diones are prepared from the corresponding 1-thione-3-one compounds by methylation followed by acid hydrolysis. The 1,3-dione products and 1-thione-3-one intermediates are useful as anti-arthritic agents.
    Type: Grant
    Filed: January 7, 1975
    Date of Patent: June 8, 1976
    Assignee: SmithKline Corporation
    Inventors: Charles E. Berkoff, Blaine M. Sutton, Joseph Weinstock
  • Anti-arthritic compositions comprising N-heterocyclic pulvinic acid amides and methods of producing anti-arthritic activity
    Patent number: 3947580
    Abstract: N-Heterocyclic pulvinic acid amides having antiarthritic activity are prepared by treating the corresponding pulvinic acid with a heterocyclic amine.
    Type: Grant
    Filed: March 27, 1975
    Date of Patent: March 30, 1976
    Assignee: SmithKline Corporation
    Inventor: Joseph Weinstock
  • Anti-arthritic compositions comprising s-heterocyclic derivatives of phosphine or phosphite gold mercaptides and methods of producing anti-arthritic activity
    Patent number: 3947565
    Abstract: S-Heterocyclic derivatives of phosphine or phosphite gold mercaptides having anti-arthritic activity are disclosed.
    Type: Grant
    Filed: January 22, 1975
    Date of Patent: March 30, 1976
    Assignee: SmithKline Corporation
    Inventors: Blaine M. Sutton, Joseph Weinstock
  • Tetramic acid analogs of pulvinic acid
    Patent number: 3931207
    Abstract: Tetramic acid analogs of pulvinic acid having anti-arthritic activity are prepared by treatment of the corresponding tetramic acid lactones with an alkali metal lower alkoxide.
    Type: Grant
    Filed: December 14, 1973
    Date of Patent: January 6, 1976
    Assignee: SmithKline Corporation
    Inventor: Joseph Weinstock