Abstract: Pharmaceutical vehicles for delivery of pharmacologically active chemical materials to mucous membranes, as well as pharmaceutically active compositions containing such vehicles, are provided. The pharmaceutical vehicles are clear, water-miscible, physiologically-acceptable, liquid compositions which gel to a thickened, non-flowing and adhering consistency at human body temperature. They are liquid at ambient room temperature and have a gel transition temperature in the range of from about 25.degree. C. to about 40.degree. C. Aqueous solutions of certain polyoxyethylene-polyoxypropylene condensates are suitable vehicles. Also provided are pharmaceutical compositions containing added pharmacologically active chemical material, i.e., a drug or medicament. A method of delivering the drug or medicament to a mucous membrane is also provided.This is a continuation of application Ser. No. 661,612, filed Feb. 26, 1976, now U.S. Pat. No. 4,100,271.

Abstract: Pharmaceutical vehicles for delivery of pharmacologically active chemical materials to mucous membranes, as well as pharmaceutically active compositions containing such vehicles, are provided. The pharmaceutical vehicles are clear, water-miscible, physiologically-acceptable, liquid compositions which gel to a thickened, non-flowing and adhering consistency at human body temperature. They are liquid at ambient room temperature and have a gel transition temperature in the range of from about 25.degree. to about 40.degree. C. Aqueous solutions of certain polyoxyethylene-polyoxypropylene condensates are suitable vehicles. Also provided are pharmaceutical compositions containing added pharmacologically active chemical material, i.e., a drug or medicament. A method of delivering the drug or medicament to a mucous membrane is also provided.

Abstract: A contact lens cleaning, storing and wetting solution is provided for cleaning, storing and wetting flexible silicone contact lenses. The solution comprises a poly (oxyethylene)- poly (oxypropylene) block copolymer having a molecular weight between about 1900 and 15,500, a water solubility in excess of about 10 grams per 100 ml., a cloud point in 1 percent aqueous solution above about 30.degree.C., and a Foam Height in excess of 30 mm; a microbial growth inhibitor, such as benzalkonium chloride; purified water; and a sufficient amount of at least one essentially neutral, water-soluble compatible salt to provide a solution salt content equivalent to about 0.5 to 1.8 percent sodium chloride. The solution can also contain disodium or trisodium ethylenediamine tetraacetate and a polymeric viscosity building agent, if desired.