Patents by Inventor Joseph Zeldis

Joseph Zeldis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis of sulfonyl halides and sulfonamides from sulfonic acid salts
    Patent number: 7842834
    Abstract: The present invention provides synthetic processes for the preparation of sulfonyl halides of Formula Ar—(R)z—SO2—X and sulfonamides of Formula Ar—(R)z—SO2—NR4R5, where the constituent variables are as defined herein, that are useful as intermediates in the preparation of pharmaceuticals.
    Type: Grant
    Filed: July 20, 2006
    Date of Patent: November 30, 2010
    Assignee: Wyeth LLC
    Inventors: Ronald S. Michalak, Jean L. Helom, Joseph Zeldis
  • Methods for preparing sulfonamide substituted alcohols and intermediates thereof
    Patent number: 7687666
    Abstract: Processes for preparing amino alcohols or salts thereof and sulfonamide substituted alcohol compounds are provided. Desirably, the sulfonamide substituted alcohol compounds are heterocyclic sulfonamide trifluoroalkyl-substituted alcohol compounds or phenyl sulfonamide trifluoroalkyl-substituted alcohol compounds.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: March 30, 2010
    Assignee: Wyeth
    Inventors: Anita Wai-Yin Chan, Jianxin Ren, Mousumi Ghosh, Arkadiy Rubezhov, Panolil Raveendranath, Joseph Zeldis
  • Methods for preparing glutamic acid derivatives
    Patent number: 7541485
    Abstract: The present invention relates to novel methods for the preparation of glutamic acid derivatives and intermediates thereof, and such compounds prepared by the novel methods.
    Type: Grant
    Filed: July 11, 2006
    Date of Patent: June 2, 2009
    Assignee: Wyeth
    Inventors: Ronald S. Michalak, Joseph Zeldis, Mel Jennings, David M. Blum, Timothy Doyle
  • Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors
    Publication number: 20090018332
    Abstract: The invention relates to processes for the preparation of the bicyclic oxazine carboxaldehyde Compound 1: The invention also relates to the use of Compound 1 in the preparation of ?-lactamase inhibitors.
    Type: Application
    Filed: June 24, 2008
    Publication date: January 15, 2009
    Applicant: Wyeth
    Inventors: Kenneth Alfred Martin Kremer, Lalitha Krishnan, Aranapakam Mudumbai Venkatesan, Mellard Norman Jennings, Joseph Zeldis, Takao Abe, Tarek Suhayl Mansour, Henry Lee Strong
  • Methods for preparing glutamic acid derivatives and intermediates thereof
    Publication number: 20080119670
    Abstract: The present invention relates to novel methods for the preparation of glutamic acid derivatives and intermediates thereof, and such compounds prepared by the novel methods.
    Type: Application
    Filed: June 1, 2007
    Publication date: May 22, 2008
    Applicant: Wyeth
    Inventors: Timothy Doyle, Joseph Zeldis, Ronald S. Michalak, David M. Blum, Mel Jennings, Julianne Blum
  • Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
    Patent number: 7361773
    Abstract: A process for making a compound of the formula comprising dialkylating a benzodioxane aniline
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: April 22, 2008
    Assignee: Wyeth
    Inventors: Anita Wai-Yin Chan, Gregg Brian Feigelson, Joseph Zeldis, Ivo Ladislav Jirkovsky
  • Process for making chiral 1,4-disubstituted piperazines
    Publication number: 20080058543
    Abstract: A process for a stereoselective preparation of novel chiral nitrogen mustard derivatives useful in synthesizing optically active 1,4-disubstituted piperazines of formula: wherein R, Ar, and Q are defined as set forth herein, and intermediate compounds therefor. The 1,4-disubstituted piperazines act as 5HT1A receptor binding agents useful in the treatment of Central Nervous System (CNS) disorders.
    Type: Application
    Filed: August 8, 2007
    Publication date: March 6, 2008
    Inventors: Joseph Zeldis, Gregg Feigelson, Ivo Jirkovsky
  • Process for synthesizing beta-lactamase inhibitor intermediates
    Publication number: 20080009634
    Abstract: There is provided a process for the preparation of bicyclicheteroaryl carboxaldehydes having the structural Formula I where X and Y are defined in the specification The bicyclic heteroaryl carboxaldehydes are useful as intermediates in the preparation of ?-lactamase inhibitors.
    Type: Application
    Filed: June 18, 2007
    Publication date: January 10, 2008
    Applicant: Wyeth Holdings Corporation
    Inventors: Michael Winkley, Anita Chan, Ivo Jirkovsky, Kenneth Kremer, Joseph Zeldis, Antonia Nikitenko, Henry Strong, Tarek Mansour, Gulnaz Khafizova, Aranapakam Venkatesan
  • Process for synthesizing beta-lactamase inhibitor intermediates
    Patent number: 7276611
    Abstract: There is provided a process for the preparation of bicyclicheteroaryl carboxaldehydes having the structural Formula I where X and Y are defined in the specification The bicyclic heteroaryl carboxaldehydes are useful as intermediates in the preparation of ?-lactamase inhibitors.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: October 2, 2007
    Assignee: Wyeth Holdings Corporation
    Inventors: Michael William Winkley, Anita Wai-Yin Chan, Ivo L. Jirkovsky, Kenneth Alfred Martin Kremer, Joseph Zeldis, Antonia Aristotelevna Nikitenko, Henry Lee Strong, Tarek Mansour, Gulnaz Khafizova, Aranapakam M. Venkatesan
  • Methods for preparing sulfonamide substituted alcohols and intermediates thereof
    Publication number: 20070197830
    Abstract: Processes for preparing amino alcohols or salts thereof and sulfonamide substituted alcohol compounds are provided. Desirably, the sulfonamide substituted alcohol compounds are heterocyclic sulfonamide trifluoroalkyl-substituted alcohol compounds or phenyl sulfonamide trifluoroalkyl-substituted alcohol compounds.
    Type: Application
    Filed: February 15, 2007
    Publication date: August 23, 2007
    Applicant: Wyeth
    Inventors: Anita Wai-Yin Chan, Jianxin Ren, Mousumi Ghosh, Arkadiy Rubezhov, Panolil Raveendranath, Joseph Zeldis
  • Process for making chiral 1,4-disubstituted piperazines
    Patent number: 7256289
    Abstract: A process for a stereoselective preparation of novel chiral nitrogen mustard derivatives useful in synthesizing optically active 1,4-disubstituted piperazines of formula: wherein R, Ar, and Q are defined as set forth herein, and intermediate compounds therefor. The 1,4-disubstituted piperazines act as 5HT1A receptor binding agents useful in the treatment of Central Nervous System (CNS) disorders. The intermediate compounds of Formula II and IV as set forth herein are also included.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: August 14, 2007
    Assignee: Wyeth
    Inventors: Ivo Ladislav Jirkovsky, Joseph Zeldis, Gregg Brian Feigelson
  • Methods for preparing glutamic acid derivatives
    Publication number: 20070088172
    Abstract: The present invention relates to novel methods for the preparation of glutamic acid derivatives and intermediates thereof, and such compounds prepared by the novel methods.
    Type: Application
    Filed: July 11, 2006
    Publication date: April 19, 2007
    Applicant: Wyeth
    Inventors: Ronald Michalak, Joseph Zeldis, Mel Jennings, David Blum, Timothy Doyle
  • Method for preparing hydroxamic acids
    Patent number: 7179911
    Abstract: Processes for using a compound of formula III: to make compounds of formulae I and II: and processes for making the compound of formula III, where R1-5 and J are as defined herein.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: February 20, 2007
    Assignee: Wyeth
    Inventors: Ting-Zhong Wang, Lalitha Krishnan, Joseph Zeldis, Jeremy I. Levin, Jean Schmid, Mellard Jennings, Huan-Qiu Li, Zhixin Wen
  • Process for the synthesis of sulfonyl halides and sulfonamides from sulfonic acid salts
    Publication number: 20070021614
    Abstract: The present invention provides synthetic processes for the preparation of sulfonyl halides of Formula Ar—(R)z—O2—X and sulfonamides of Formula Ar—(R)2—SO2—NR4R5, where the constituent variables are as defined herein, that are useful as intermediates in the preparation of pharmaceuticals.
    Type: Application
    Filed: July 20, 2006
    Publication date: January 25, 2007
    Applicant: Wyeth
    Inventors: Ronald Michalak, Jean Helom, Joseph Zeldis
  • Process for synthesizing N-aryl piperazines with chiral N?-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
    Patent number: 7091349
    Abstract: A process for formation of N-aryl piperazines with chiral N?-1-[benzoyl(2-pyridyl)amino]-2-propane side-chains having the structure shown in formula below, and for making intermediate compounds therefor. In this process, chirality is introduced at the piperazine ring formation step and 2-aminopyridyl substitution is incorporated via displacement. The resulting N, N? disubstituted piperazines act on the central nervous system at 5HT receptors.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: August 15, 2006
    Assignee: Wyeth
    Inventors: Gregg Brian Feigelson, Joseph Zeldis, Ivo Ladislav Jirkovsky
  • Process for making chiral 1,4-disubstituted piperazines
    Patent number: 7019137
    Abstract: A process for a stereoselective preparation of novel chiral nitrogen mustard derivatives useful in synthesizing optically active 1,4-disubstituted piperazines of formula: wherein R, Ar, and Q are defined as set forth herein, and intermediate compounds therefor. The 1,4-disubstituted piperazines act as 5HT1A receptor binding agents useful in the treatment of Central Nervous System (CNS) disorders.
    Type: Grant
    Filed: March 10, 2003
    Date of Patent: March 28, 2006
    Assignee: Wyeth
    Inventors: Ivo Jirkovsky, Joseph Zeldis, Gregg Brian Feigelson
  • Method for preparing hydroxamic acids
    Publication number: 20050272928
    Abstract: Processes for using a compound of formula III: to make compounds of formulae I and II: and processes for making the compound of formula III, where R1-5 and J are as defined herein.
    Type: Application
    Filed: June 7, 2005
    Publication date: December 8, 2005
    Applicant: Wyeth
    Inventors: Ting-Zhong Wang, Lalitha Krishnan, Joseph Zeldis, Jeremy Levin, Jean Schmid, Mellard Jennings, Huan-Qiu Li, Zhixin Wen
  • Process for making chiral 1,4-disubstituted piperazines
    Publication number: 20050228181
    Abstract: A process for a stereoselective preparation of novel chiral nitrogen mustard derivatives useful in synthesizing optically active 1,4-disubstituted piperazines of formula: wherein R, Ar, and Q are defined as set forth herein, and intermediate compounds therefor. The 1,4-disubstituted piperazines act as 5HT1A receptor binding agents useful in the treatment of Central Nervous System (CNS) disorders.
    Type: Application
    Filed: June 7, 2005
    Publication date: October 13, 2005
    Applicant: Wyeth
    Inventors: Joseph Zeldis, Gregg Feigelson, Ivo Jirkovsky
  • Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
    Publication number: 20050070709
    Abstract: A process for making an N1-(2?-pyridyl)-1,2-alkanediamine sulfamic acid of formula II by reacting a compound of formula I with NH2R? wherein R and R? are as defined in the specification. The invention also includes the compound of formula II, and optical isomers thereof. The compound of formula II is an intermediate useful for making chiral piperazine derivatives which are active at the 5-HT1A receptor.
    Type: Application
    Filed: August 16, 2004
    Publication date: March 31, 2005
    Applicant: Wyeth
    Inventors: Anita Chan, Gregg Feigelson, Joseph Zeldis, Ivo Jirkovsky
  • Process for synthesizing beta-lactamase inhibitor intermediates
    Publication number: 20040242874
    Abstract: There is provided a process for the preparation of bicyclicheteroaryl carboxaldehydes having the structural Formula I where X and Y are defined in the specification 1
    Type: Application
    Filed: May 12, 2004
    Publication date: December 2, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Michael William Winkley, Anita Wai-Yin Chan, Ivo L. Jirkovsky, Kenneth Alfred Martin Kremer, Joseph Zeldis, Antonia Aristotelevna Nikitenko, Henry Lee Strong, Tarek Mansour, Gulnaz Khafizova, Aranapakam M. Venkatesan