Abstract: A diffusion/permeation cell, commonly referred to as a Franz cell, is provided for topical or transdermal drug delivery research and development in the pharmaceutical industry. The cell comprises a receptor container, a donor chamber, a quick clamping apparatus, and/or an assembly tool. Systems and methods provide a cost-effective diffusion cell, especially for use with an automatic diffusion release testing system.

Abstract: The present invention is a breath sample collecting mask comprising a mask body and a breath sample collector that provides non-invasive sample collection for detection of infectious diseases as well as lung and respiratory diseases, potentially before the onset of symptoms. The breath sample collector contains a filter that catches viral, bacterial, and other biomarker particles. The breath sample collector can be removed from the mask and placed into a tube for sample elution and further processing and analysis. The breath sample collecting mask may further comprise a thermometer, electrodes attached on the filter of the sample collector, and a microprocessor to monitor the mask wearer's condition.

Abstract: Provided is a wearable smart drug-delivery system, including a power supply, a drug sac structure, a repository, and an electrode structure. The wearable smart drug-delivery system can accurately and precisely control the dosage and delivery time of an ionized pharmaceutical agent, reducing and preventing uncontrolled doses of transdermally delivered drugs. A plurality of drugs may be stored in one repository or a plurality of repositories in the wearable smart drug-delivery system, and may, at the same time or at different times, be delivered into the body by means of one or a plurality of power supplies; furthermore, storing the plurality of drugs in the plurality of repositories can prevent reactions and interferences between drugs.

Abstract: A device for transdermal drug delivery and administration of differing dosages at specific times of the day automatically pursuant to a pre-programmed dosage profile. The device includes a control and display unit, a two-part dispensing mechanism, a drug reservoir, an administration element, and a solvent removal element. The dispensing mechanism may be a peristaltic pump having an active portion with a motor, a roller, a mounting plate and a detachable passive portion with tubing and a housing. The motor and roller are mounted in the reusable portion of the delivery device with the control unit and a power source. The speed of the micromotor is controlled by the control unit, so that the turning speed of the roller is controlled which, in turn, controls the flow rate to the administration. The passive portion and drug reservoir are detachable along with the administration element for attaching a new dosing reservoir.

Abstract: The instant application provides a fluidic array device having an elastomeric body that provides easy fluidic control of the device. The elastomeric body may include plurality of intersecting row and column channels. Reactions may occur at the intersection spots formed by the intersecting channels. Pinching applied at suitable locations along the channels enables the channels to be opened or closed, and thus provides control of fluids pumped through the device. The surfaces of the channels and intersection spots may be engineered to have certain properties. In particular, the intersection spots may be nanoengineered to have surface properties differing from those of the channels, and thus reactions may be selectively controlled to occur only, or highly preferentially, in the intersection spots.

Abstract: The instant application provides a fluidic array device having an elastomeric body that provides easy fluidic control of the device. The elastomeric body may include plurality of intersecting row and column channels. Reactions may occur at the intersection spots formed by the intersecting channels. Pinching applied at suitable locations along the channels enables the channels to be opened or closed, and thus provides control of fluids pumped through the device. The surfaces of the channels and intersection spots may be engineered to have certain properties. In particular, the intersection spots may be nanoengineered to have surface properties differing from those of the channels, and thus reactions may be selectively controlled to occur only, or highly preferentially, in the intersection spots.

Abstract: A device for transdermal drug delivery and administration of differing dosages at specific times of the day automatically pursuant to a pre-programmed dosage profile. The device includes a control and display unit, a two-part dispensing mechanism, a drug reservoir, an administration element, and a solvent removal element. The dispensing mechanism may be a peristaltic pump having an active portion with a motor, a roller, a mounting plate and a detachable passive portion with tubing and a housing. The motor and roller are mounted in the reusable portion of the delivery device with the control unit and a power source. The speed of the micromotor is controlled by the control unit, so that the turning speed of the roller is controlled which, in turn, controls the flow rate to the administration. The passive portion and drug reservoir are detachable along with the administration element for attaching a new dosing reservoir.