Patents by Inventor Joseph Zielinski

Joseph Zielinski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200152333
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for predicting future adverse health events using neural networks. One of the methods includes receiving electronic health record data for a patient; generating, from the electronic health record data, an input sequence comprising a respective feature representation at each of a plurality of time window time steps, comprising, for each time window time step: determining, for each of the possible numerical features, whether the numerical feature occurred during the time window; and generating, for each of the possible numerical features, one or more presence features that identify whether the numerical feature occurred during the time window; and processing the input sequence using a neural network to generate a neural network output that characterizes a predicted likelihood that an adverse health event will occur to the patient.
    Type: Application
    Filed: November 13, 2019
    Publication date: May 14, 2020
    Inventors: Nenad Tomasev, Xavier Glorot, Jack William Rae, Michal Zielinski, Anne Mottram, Harry Askham, Andre Saraiva Nobre Dos Santos, Clemens Ludwig Meyer, Suman Ravuri, Ivan Protsyuk, Trevor Back, Joseph R. Ledsam, Shakir Mohamed
  • Patent number: 10543039
    Abstract: A medical device for sympathetic nerve ablation includes a catheter shaft and an expandable member disposed on the catheter shaft. The balloon is configured to be able to shift between an unexpanded configuration and an expanded configuration. The medical device includes an elongate electrode assembly constructed as a flexible circuit and a protective bumper member. The elongate electrode assembly may have an outer edge and may be disposed on an outer surface of the balloon. The protective bumper member may cover at least a portion of the outer edge of the elongate electrode assembly.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: January 28, 2020
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Jeffrey S. Lindquist, Joseph Zielinski, Mark S. Smith, Kevin Martin, Joel R. Munsinger
  • Publication number: 20180333172
    Abstract: A cutting balloon catheter including a balloon mounted on a distal portion of a catheter shaft. The balloon includes a cutting member mounted on an exterior surface of the balloon which includes one or more features for providing the cutting member with enhanced flexibility for navigating tortuous anatomy and more closely conforms to the expansion characteristics of the balloon to which the cutting member is mounted.
    Type: Application
    Filed: July 30, 2018
    Publication date: November 22, 2018
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Richard Gunderson, Joseph Zielinski
  • Patent number: 10058349
    Abstract: A cutting balloon catheter including a balloon mounted on a distal portion of a catheter shaft. The balloon includes a cutting member mounted on an exterior surface of the balloon which includes one or more features for providing the cutting member with enhanced flexibility for navigating tortuous anatomy and more closely conforms to the expansion characteristics of the balloon to which the cutting member is mounted.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: August 28, 2018
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Richard Gunderson, Joseph Zielinski
  • Publication number: 20160081711
    Abstract: A cutting balloon catheter including a balloon mounted on a distal portion of a catheter shaft. The balloon includes a cutting member mounted on an exterior surface of the balloon which includes one or more features for providing the cutting member with enhanced flexibility for navigating tortuous anatomy and more closely conforms to the expansion characteristics of the balloon to which the cutting member is mounted.
    Type: Application
    Filed: December 1, 2015
    Publication date: March 24, 2016
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Richard Gunderson, Joseph Zielinski
  • Patent number: 9226768
    Abstract: A cutting balloon catheter including a balloon mounted on a distal portion of a catheter shaft. The balloon includes a cutting member mounted on an exterior surface of the balloon which includes one or more features for providing the cutting member with enhanced flexibility for navigating tortuous anatomy and more closely conforms to the expansion characteristics of the balloon to which the cutting member is mounted.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: January 5, 2016
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Richard Gunderson, Joseph Zielinski
  • Publication number: 20150265339
    Abstract: A medical device for sympathetic nerve ablation includes a catheter shaft and an expandable member disposed on the catheter shaft. The balloon is configured to be able to shift between an unexpanded configuration and an expanded configuration. The medical device includes an elongate electrode assembly constructed as a flexible circuit and a protective bumper member. The elongate electrode assembly may have an outer edge and may be disposed on an outer surface of the balloon. The protective bumper member may cover at least a portion of the outer edge of the elongate electrode assembly.
    Type: Application
    Filed: March 13, 2015
    Publication date: September 24, 2015
    Applicant: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: JEFFREY S. LINDQUIST, JOSEPH ZIELINSKI, MARK S. SMITH, KEVIN MARTIN, JOEL R. MUNSINGER
  • Publication number: 20150005799
    Abstract: A balloon for renal nerve modulation, the balloon comprising a polymer material forming a balloon wall having an interior surface and an exterior surface and flexible circuits adhesively bonded to the exterior surface of the balloon wall, wherein the exterior surface comprises laser induced microstructures on at least a portion of said exterior surface.
    Type: Application
    Filed: June 26, 2014
    Publication date: January 1, 2015
    Inventors: JEFFREY S. LINDQUIST, CASS A. HANSON, DEREK C. SUTERMEISTER, DANIEL T. QUILLIN, PETER G. EDELMAN, AJAY GUPTA, JOSEPH A. ZIELINSKI, GARY J. PEDERSON, JR., LIZA J. DAVIS, HENRY H. LEE
  • Patent number: 8658695
    Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. Preferred delivery agents include, but are not limited to, N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC), N-(10-[2-hydroxybenzoyl]amino)decanoic acid (SNAD), and sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC). The invention also provides methods of preparing the disodium salt, ethanol solvate, and hydrate and compositions containing the disodium salt, ethanol solvate, and/or hydrate.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: February 25, 2014
    Assignees: Emisphere Technologies, Inc., Novartis AG
    Inventors: William Elliott Bay, Rajesh K. Agarwal, Kiran Chaudhary, Shingai Majuru, Michael M. Goldberg, JoAnne P. Corvino, Moise Azria, Joseph Ault, Simon D. Bateman, Subash Patel, Joseph Sikora, Rebecca F. Yang, Joseph Zielinski
  • Publication number: 20130018396
    Abstract: A cutting balloon catheter including a balloon mounted on a distal portion of a catheter shaft. The balloon includes a cutting member mounted on an exterior surface of the balloon which includes one or more features for providing the cutting member with enhanced flexibility for navigating tortuous anatomy and more closely conforms to the expansion characteristics of the balloon to which the cutting member is mounted.
    Type: Application
    Filed: July 13, 2012
    Publication date: January 17, 2013
    Applicant: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Richard Gunderson, Joseph Zielinski
  • Patent number: 8207227
    Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein R1, R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R5 is a substituted or unsubstituted C2-C16alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of the formula above.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: June 26, 2012
    Assignees: Emisphere Technologies, Inc., Novartis AG
    Inventors: William E. Bay, Rajesh K. Agarwal, Kiran Chaudhary, Michael M. Goldberg, Joanne P. Corvino, Shingai Majuru, Moise Azria, Joseph Ault, Simon D. Bateman, Subash Patel, Joseph Sikora, Rebecca F. Yang, Joseph Zielinski
  • Patent number: 8003697
    Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein R1, R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R5 is a substituted or unsubstituted C2-C16 alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of the formula above.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: August 23, 2011
    Assignees: Emisphere Technologies, Inc., Novartis AG
    Inventors: William Elliot Bay, Rajesh K. Agarwal, Kiran Chaudhary, Michael M. Goldberg, JoAnne P. Corvino, Shingai Majura, Moise Azria, Joseph Ault, Simon D. Bateman, Subash Patel, Joseph Sikora, Rebecca F. Yang, Joseph Zielinski
  • Patent number: 7915314
    Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein R1, R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R5 is a substituted or unsubstituted C2-C16 alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of the formula above.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: March 29, 2011
    Assignees: Emisphere Technologies, Inc., Novartis AG
    Inventors: William Elliot Bay, Rajesh K. Agarwal, Kiran Chaudhary, Michael M. Goldberg, JoAnne P. Corvino, Shingai Majura, Moise Azria, Joseph Ault, Simon D. Bateman, Subash Patel, Joseph Sikora, Rebecca F. Yang, Joseph Zielinski
  • Publication number: 20060153920
    Abstract: Pharmaceutical compositions that include a poorly water-soluble therapeutic compound, an aqueous solvent, a nonvolatile cosolvent and a bulking agent. The pharmaceutical compositions can be orally ingested or administered parenterally. The pharmaceutical compositions can further be lyophilized to form a pharmaceutically acceptable cake that can be administered orally, e.g., as a solid oral dosage form; or reconstituted and administered parenterally, e.g. as a single i.v. bolus.
    Type: Application
    Filed: December 20, 2005
    Publication date: July 13, 2006
    Inventors: Ketan Amin, Rose-Marie Dannenfelser, Joseph Zielinski, Barbara Wang
  • Publication number: 20060094787
    Abstract: Provided are compositions comprising aqueous suspensions of 5-methyl-2-(2?-chloro-6?-fluoroanilino)phenylacetic acid suitable for oral administration. Methods for making such compositions and methods for their stabilization are provided.
    Type: Application
    Filed: March 11, 2004
    Publication date: May 4, 2006
    Inventors: Patrick Forenzo, Maha Khaled, Barbara Wang, Joseph Zielinski
  • Publication number: 20060068008
    Abstract: Pharmaceutical compositions that include a poorly water-soluble therapeutic compound, an aqueous solvent, a nonvolatile cosolvent and a bulking agent. The pharmaceutical compositions can be orally ingested or administered parenterally. The pharmaceutical compositions can further be lyophilized to form a pharmaceutically acceptable cake that can be administered orally, e.g., as a solid oral dosage form; or reconstituted and administered parenterally, e.g. as a single i.v. bolus.
    Type: Application
    Filed: September 19, 2005
    Publication date: March 30, 2006
    Inventors: Ketan Amin, Rose-Marie Dannenfelser, Joseph Zielinski, Barbara Wang
  • Patent number: 5780408
    Abstract: A solution for use in removing the double sided adhesive tape from mouldings used on motor vehicles and the like. The solution comprises (a) 60-97% by weight of kerosene, (b) 2-27% by weight of oil of turpentine, (c) 1-10% by weight of an oil based surface active agent selected from the group consisting of castor oil and linseed oil, and 0-3% weight of a perfume.
    Type: Grant
    Filed: May 23, 1996
    Date of Patent: July 14, 1998
    Assignee: MMZ Solutions Pty. Ltd.
    Inventors: Mark John Russell, Michael John Rickhuss, Zygmunt Joseph Zielinski