Patents by Inventor Joseph Zitelli
Joseph Zitelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20050169964Abstract: A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein such as OP-1 protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.Type: ApplicationFiled: February 17, 2005Publication date: August 4, 2005Applicant: Howmedica Osteonics Corp.Inventors: Joseph Zitelli, Paul Higham, Paresh Dalal, Christopher Scott
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Patent number: 6821528Abstract: A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.Type: GrantFiled: July 1, 2003Date of Patent: November 23, 2004Assignee: Howmedica Osteonics Corp.Inventors: Christopher Scott, Joseph Zitelli, Paul Higham
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Publication number: 20040141903Abstract: A mixture of two or more calcium phosphate compositions are combined with an aqueous solution and are useful as bone fillers on bone cements such as orthopedic and dental cements and remineralizers. The mixtures self-harden to substantially form hydroxyapatite, the mineral phase of bone and tooth enamel. The at least one or more of precursors is prepared in a manner resulting in its having an extremely low moisture level. The use of low moisture components results in an improved shelf life to the mixture.Type: ApplicationFiled: January 17, 2003Publication date: July 22, 2004Applicant: Howmedica Osteonics Corp.Inventors: Joseph Zitelli, Peter Maher, Ger Insley
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Publication number: 20040131754Abstract: A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein such as OP-1 protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.Type: ApplicationFiled: July 1, 2003Publication date: July 8, 2004Applicant: Howmedica Osteonics Corp.Inventors: Joseph Zitelli, Paul Higham, Paresh Dalal, Monica Hawkins, Renwen Zhang
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Publication number: 20040001911Abstract: A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.Type: ApplicationFiled: July 1, 2003Publication date: January 1, 2004Applicant: Howmedica Osteonics Corp.Inventors: Christopher Scott, Joseph Zitelli, Paul Higham
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Patent number: 6670293Abstract: A kit and a method for making a porous cement which self sets to hydroxyapatite and has an interconnected porosity is produced by mixing a calcium source and a phosphate source with a carbonate source and mixing this powdered component with a liquid component having an acid component. The liquid component comprises water or an aqueous solution containing an acid. The acid and the carbonate react to form carbon dioxide thereby producing an interconnected porosity in the normally solid self-hardening bone cement. The method requires only a relatively low weight percent of the acid and base to be mixed with the liquid and powder cement components.Type: GrantFiled: September 9, 2002Date of Patent: December 30, 2003Assignee: Howmedica Osteonics Corp.Inventors: Brian Edwards, Paul Higham, Joseph Zitelli
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Patent number: 6596338Abstract: A process for applying a coating having a therapeutic agent such as an antibiotic to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.Type: GrantFiled: October 24, 2001Date of Patent: July 22, 2003Assignee: Howmedica Osteonics Corp.Inventors: Christopher Scott, Joseph Zitelli, Paul Higham
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Patent number: 6592251Abstract: An apparatus and method for mixing a liquid component and a powdered component to form a bone filler has first and second syringes each having a barrel, a plunger and an exit port. The plunger is moveable with the barrel of each syringe along a longitudinal axis of the barrel. An end portion of each plunger extends beyond the end of each barrel when the plunger tip is spaced from the exit port and can be activated to move the plunger tip toward the exit port. A mechanism for mixing the liquid and powdered components is operatively connected to each of the barrels and plungers of the first and second syringes so that the relative sliding movement of first and second parts of the mechanism simultaneously moves the plungers and barrels of the first and second syringes relative to one another to move the combined liquid and powdered components back and forth between the first and second syringe.Type: GrantFiled: January 26, 2001Date of Patent: July 15, 2003Assignee: Howmedica Osteonics Corp.Inventors: Brian Edwards, Paul Higham, Joseph Zitelli
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Publication number: 20030077381Abstract: A process for applying a coating having a therapeutic agent such as an antibiotic to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.Type: ApplicationFiled: October 24, 2001Publication date: April 24, 2003Inventors: Christopher Scott, Joseph Zitelli, Paul Higham
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Patent number: 6547866Abstract: A kit and a method for making a porous cement which self sets to hydroxyapatite and has an interconnected porosity is produced by mixing a calcium source and a phosphate source with a carbonate source and mixing this powdered component with a liquid component having an acid component. The liquid component comprises water or an aqueous solution containing an acid. The acid and the carbonate react to form carbon dioxide thereby producing an interconnected porosity in the normally solid self-hardening bone cement. The method requires only a relatively low weight percent of the acid and base to be mixed with the liquid and powder cement components.Type: GrantFiled: October 30, 2000Date of Patent: April 15, 2003Assignee: Howmedica Osteonics Corp.Inventors: Brian Edwards, Paul Higham, Joseph Zitelli
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Publication number: 20030019396Abstract: A kit and a method for making a porous cement which self sets to hydroxyapatite and has an interconnected porosity is produced by mixing a calcium source and a phosphate source with a carbonate source and mixing this powdered component with a liquid component having an acid component. The liquid component comprises water or an aqueous solution containing an acid. The acid and the carbonate react to form carbon dioxide thereby producing an interconnected porosity in the normally solid self-hardening bone cement. The method requires only a relatively low weight percent of the acid and base to be mixed with the liquid and powder cement components.Type: ApplicationFiled: September 9, 2002Publication date: January 30, 2003Applicant: Howmedica Osteonics Corp.Inventors: Brian Edwards, Paul Higham, Joseph Zitelli
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Patent number: 6494611Abstract: An apparatus for mixing dry and liquid components is used to form a setting paste. A holder is mounted on the apparatus for reciprocating movement with respect to a base of the apparatus. The movement has an amplitude with components in first and second perpendicular directions. A drive system is operatively connected to the holder for imparting said reciprocating movement to said holder at a predetermined number of cycles per minute. A container having a mass of said dry and liquid components therein is mounted in the holder. The mass, amplitude and cycles per minute of reciprocation being chosen to produce an energy input of at least about 3×10−3 Joules per second per 3 cc of mixture.Type: GrantFiled: January 26, 2001Date of Patent: December 17, 2002Assignee: Howmedica Osteonics Corp.Inventors: Brian Edwards, Paul Higham, Joseph Zitelli
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Publication number: 20020101784Abstract: An apparatus for mixing dry and liquid components is used to form a setting paste. A holder is mounted on the apparatus for reciprocating movement with respect to a base of the apparatus. The movement has an amplitude with components in first and second perpendicular directions. A drive system is operatively connected to the holder for imparting said reciprocating movement to said holder at a predetermined number of cycles per minute. A container having a mass of said dry and liquid components therein is mounted in the holder. The mass, amplitude and cycles per minute of reciprocation being chosen to produce an energy input of at least about 3×10−3 Joules per second per 3 cc of mixture.Type: ApplicationFiled: January 26, 2001Publication date: August 1, 2002Applicant: Howmedica Osteonics Corp.Inventors: Brian Edwards, Paul Higham, Joseph Zitelli
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Publication number: 20020101785Abstract: An apparatus and method for mixing a liquid component and a powdered component to form a bone filler has first and second syringes each having a barrel, a plunger and an exit port. The plunger is moveable with the barrel of each syringe along a longitudinal axis of the barrel. An end portion of each plunger extends beyond the end of each barrel when the plunger tip is spaced from the exit port and can be activated to move the plunger tip toward the exit port. A mechanism for mixing the liquid and powdered components is operatively connected to each of the barrels and plunger of the first and second syringes so that the relative sliding movement of first and second parts of the mechanism simultaneously moves the plungers and barrels of the first and second syringes relative to one another to move the combined liquid and powdered components back and forth between the first and second syringe.Type: ApplicationFiled: January 26, 2001Publication date: August 1, 2002Applicant: Howmedica Osteonics Corp.Inventors: Brian Edwards, Paul Higham, Joseph Zitelli