Patents by Inventor Joseph Zitelli

Joseph Zitelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050169964
    Abstract: A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein such as OP-1 protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.
    Type: Application
    Filed: February 17, 2005
    Publication date: August 4, 2005
    Applicant: Howmedica Osteonics Corp.
    Inventors: Joseph Zitelli, Paul Higham, Paresh Dalal, Christopher Scott
  • Patent number: 6821528
    Abstract: A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.
    Type: Grant
    Filed: July 1, 2003
    Date of Patent: November 23, 2004
    Assignee: Howmedica Osteonics Corp.
    Inventors: Christopher Scott, Joseph Zitelli, Paul Higham
  • Publication number: 20040141903
    Abstract: A mixture of two or more calcium phosphate compositions are combined with an aqueous solution and are useful as bone fillers on bone cements such as orthopedic and dental cements and remineralizers. The mixtures self-harden to substantially form hydroxyapatite, the mineral phase of bone and tooth enamel. The at least one or more of precursors is prepared in a manner resulting in its having an extremely low moisture level. The use of low moisture components results in an improved shelf life to the mixture.
    Type: Application
    Filed: January 17, 2003
    Publication date: July 22, 2004
    Applicant: Howmedica Osteonics Corp.
    Inventors: Joseph Zitelli, Peter Maher, Ger Insley
  • Publication number: 20040131754
    Abstract: A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein such as OP-1 protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.
    Type: Application
    Filed: July 1, 2003
    Publication date: July 8, 2004
    Applicant: Howmedica Osteonics Corp.
    Inventors: Joseph Zitelli, Paul Higham, Paresh Dalal, Monica Hawkins, Renwen Zhang
  • Publication number: 20040001911
    Abstract: A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.
    Type: Application
    Filed: July 1, 2003
    Publication date: January 1, 2004
    Applicant: Howmedica Osteonics Corp.
    Inventors: Christopher Scott, Joseph Zitelli, Paul Higham
  • Patent number: 6670293
    Abstract: A kit and a method for making a porous cement which self sets to hydroxyapatite and has an interconnected porosity is produced by mixing a calcium source and a phosphate source with a carbonate source and mixing this powdered component with a liquid component having an acid component. The liquid component comprises water or an aqueous solution containing an acid. The acid and the carbonate react to form carbon dioxide thereby producing an interconnected porosity in the normally solid self-hardening bone cement. The method requires only a relatively low weight percent of the acid and base to be mixed with the liquid and powder cement components.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: December 30, 2003
    Assignee: Howmedica Osteonics Corp.
    Inventors: Brian Edwards, Paul Higham, Joseph Zitelli
  • Patent number: 6596338
    Abstract: A process for applying a coating having a therapeutic agent such as an antibiotic to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: July 22, 2003
    Assignee: Howmedica Osteonics Corp.
    Inventors: Christopher Scott, Joseph Zitelli, Paul Higham
  • Patent number: 6592251
    Abstract: An apparatus and method for mixing a liquid component and a powdered component to form a bone filler has first and second syringes each having a barrel, a plunger and an exit port. The plunger is moveable with the barrel of each syringe along a longitudinal axis of the barrel. An end portion of each plunger extends beyond the end of each barrel when the plunger tip is spaced from the exit port and can be activated to move the plunger tip toward the exit port. A mechanism for mixing the liquid and powdered components is operatively connected to each of the barrels and plungers of the first and second syringes so that the relative sliding movement of first and second parts of the mechanism simultaneously moves the plungers and barrels of the first and second syringes relative to one another to move the combined liquid and powdered components back and forth between the first and second syringe.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: July 15, 2003
    Assignee: Howmedica Osteonics Corp.
    Inventors: Brian Edwards, Paul Higham, Joseph Zitelli
  • Publication number: 20030077381
    Abstract: A process for applying a coating having a therapeutic agent such as an antibiotic to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.
    Type: Application
    Filed: October 24, 2001
    Publication date: April 24, 2003
    Inventors: Christopher Scott, Joseph Zitelli, Paul Higham
  • Patent number: 6547866
    Abstract: A kit and a method for making a porous cement which self sets to hydroxyapatite and has an interconnected porosity is produced by mixing a calcium source and a phosphate source with a carbonate source and mixing this powdered component with a liquid component having an acid component. The liquid component comprises water or an aqueous solution containing an acid. The acid and the carbonate react to form carbon dioxide thereby producing an interconnected porosity in the normally solid self-hardening bone cement. The method requires only a relatively low weight percent of the acid and base to be mixed with the liquid and powder cement components.
    Type: Grant
    Filed: October 30, 2000
    Date of Patent: April 15, 2003
    Assignee: Howmedica Osteonics Corp.
    Inventors: Brian Edwards, Paul Higham, Joseph Zitelli
  • Publication number: 20030019396
    Abstract: A kit and a method for making a porous cement which self sets to hydroxyapatite and has an interconnected porosity is produced by mixing a calcium source and a phosphate source with a carbonate source and mixing this powdered component with a liquid component having an acid component. The liquid component comprises water or an aqueous solution containing an acid. The acid and the carbonate react to form carbon dioxide thereby producing an interconnected porosity in the normally solid self-hardening bone cement. The method requires only a relatively low weight percent of the acid and base to be mixed with the liquid and powder cement components.
    Type: Application
    Filed: September 9, 2002
    Publication date: January 30, 2003
    Applicant: Howmedica Osteonics Corp.
    Inventors: Brian Edwards, Paul Higham, Joseph Zitelli
  • Patent number: 6494611
    Abstract: An apparatus for mixing dry and liquid components is used to form a setting paste. A holder is mounted on the apparatus for reciprocating movement with respect to a base of the apparatus. The movement has an amplitude with components in first and second perpendicular directions. A drive system is operatively connected to the holder for imparting said reciprocating movement to said holder at a predetermined number of cycles per minute. A container having a mass of said dry and liquid components therein is mounted in the holder. The mass, amplitude and cycles per minute of reciprocation being chosen to produce an energy input of at least about 3×10−3 Joules per second per 3 cc of mixture.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: December 17, 2002
    Assignee: Howmedica Osteonics Corp.
    Inventors: Brian Edwards, Paul Higham, Joseph Zitelli
  • Publication number: 20020101785
    Abstract: An apparatus and method for mixing a liquid component and a powdered component to form a bone filler has first and second syringes each having a barrel, a plunger and an exit port. The plunger is moveable with the barrel of each syringe along a longitudinal axis of the barrel. An end portion of each plunger extends beyond the end of each barrel when the plunger tip is spaced from the exit port and can be activated to move the plunger tip toward the exit port. A mechanism for mixing the liquid and powdered components is operatively connected to each of the barrels and plunger of the first and second syringes so that the relative sliding movement of first and second parts of the mechanism simultaneously moves the plungers and barrels of the first and second syringes relative to one another to move the combined liquid and powdered components back and forth between the first and second syringe.
    Type: Application
    Filed: January 26, 2001
    Publication date: August 1, 2002
    Applicant: Howmedica Osteonics Corp.
    Inventors: Brian Edwards, Paul Higham, Joseph Zitelli
  • Publication number: 20020101784
    Abstract: An apparatus for mixing dry and liquid components is used to form a setting paste. A holder is mounted on the apparatus for reciprocating movement with respect to a base of the apparatus. The movement has an amplitude with components in first and second perpendicular directions. A drive system is operatively connected to the holder for imparting said reciprocating movement to said holder at a predetermined number of cycles per minute. A container having a mass of said dry and liquid components therein is mounted in the holder. The mass, amplitude and cycles per minute of reciprocation being chosen to produce an energy input of at least about 3×10−3 Joules per second per 3 cc of mixture.
    Type: Application
    Filed: January 26, 2001
    Publication date: August 1, 2002
    Applicant: Howmedica Osteonics Corp.
    Inventors: Brian Edwards, Paul Higham, Joseph Zitelli