Abstract: A turbomachine includes an annular casing and a fan disposed inside the annular casing and mounted for rotation about an axial centerline. The annular casing is formed at least partially of a composite material. The fan includes fan blades that extend radially outwardly toward the annular casing. The fan has an average chord fan width according to a first performance factor. The fan has a quantity of fan blades according to a second performance factor.

Abstract: A computer network and method of designing a microwave communication and/or power system for an application. The system includes a processor configured to obtain a design parameter for the application, determine a plurality of architectures for the application based on the design parameter and an attribute of a component or waveguide of the architecture, determine a value metric for each of the plurality of architectures, and determine a reduced set of architectures for the application from the plurality of architecture based on the value metric.

Abstract: Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.

Abstract: Provided herein are post-synthesis methods of thermally stabilizing a metal-organic framework having defects that decomposes after about 12 hours at a first temperature. The methods include contacting the metal-organic framework with a stabilizing solution to provide a treated metal-organic framework. The treated metal-organic framework is thermally stable after 12 hours at a second temperature at least about 50° C. greater than the first temperature. Also, the treated metal-organic framework has a PXRD pattern that is substantially the same as the PXRD pattern of the untreated metal-organic framework. Provided herein are also post-synthesis methods to improve CO2 adsorption of metal-organic frameworks. Provided herein are also modified EMM-71 metal-organic frameworks.

Abstract: Methods and compositions for preventing or treating cognitive decline associated with dementia and/or mild cognitive impairment and/or neurodegeneration using antibodies, peptides, fusion proteins, or genome editing systems that modulate HSPG/heparin binding affinities of ApoE.

Abstract: Hypoxia-induced deoxy hemoglobin concentration ([dOHb]) may be used as a susceptibility contrast agent in subjects. While the maximal rate of generating blood [dOHb] are limited by constraints in pulmonary gas mixing, decreasing dOHb with reoxygenation of the lungs can be accomplished in one breath, resulting in a step reduction in arterial [dOHb] and thereby a step increase in cerebral BOLD signal recorded with MRI. The BOLD signal changes accompanying a step decrease in [dOHb] can be analyzed to calculate cerebral perfusion measures and compare their maps to those obtained using a bolus of a conventional contrast agent, gadolinium, and a conventional analysis requiring the identification of an arterial input function. The two methods provided comparable anatomically-distributed hemodynamic information.

Abstract: An artificial lung system for a patient having a membrane lung system having an gas inlet, a blood inlet, a blood outlet, and an exhaust; a gas system operably coupled to the gas inlet of the membrane lung system; a gas phase sensor disposed downstream of the exhaust of the membrane lung system and monitoring an exhaust gas levels; and a feedback controller receiving the blood CO2 or O2 signal and outputting a control signal to control gas flow and/or blood flow.

Abstract: Disclosed herein are testing apparatuses for testing stresses in substrates. The testing apparatus includes a base, a first plate coupled to the base, the first plate being movable relative to the base along a first axis, a second plate coupled to the base, the second plate being movable relative to the base and relative to the first plate along a second axis that is perpendicular to the first axis, a first actuator operable to move the first plate along the first axis towards or away from the second plate, a second actuator operable to move the second plate along the second axis relative to the first plate, and a controller operatively connected to the first actuator and the second actuator operable to control movement of the first plate and the second plate.

Abstract: A handheld light assembly for eradicating pathogens includes a housing. A processor and a lamp are disposed inside the housing. The lamp irradiates surfaces with disinfecting ultraviolet light having a peak wavelength of 222 nm filtered to restrict illumination to between 200 nm and 230 nm within an irradiation zone. A distance measuring system includes a secondary light source generating secondary light and a photodetector for measuring distance of the secondary light to a surface being irradiated by the lamp light being reflected from the surface to the photodetector. The secondary light source is offset at an angle from the lamp thereby projecting the light beam to a central area of the irradiation zone generated by the lamp. The photodetector signals the processor to calculate a vertical distance between the lamp and the central area of the irradiation zone on the surface being irradiated from an angular projection of the secondary light.

Abstract: The present disclosure relates to compounds and compositions for inhibition of RAF serine/threonine protein kinases and inhibition of Bcr-Abl tyrosine kinases, methods of preparing said compounds and compositions, and their use in the treatment of various cancers, such as melanoma, non-small cell lung cancer, and chronic myeloid leukemia (CML).

Abstract: Materials composed of inorganic and organic compounds that inhibit, promote and stabilize nanostructured crystalline calcium carbonate for the recruitment and growth of oyster larvae and spat. By using simple chemical precursors in a bottom-up or top-down approach, a variety of layered material compositions can be obtained which result in a standalone material or one that can be applied to and supported by cementitious substrates. The chemical compounds and processes described in this invention are scalable, thus providing for manufacturing small or large quantities of tailored materials, utilizing a variety of techniques, such as but not limited to 3-D printing, spraying, molding and freeze casting to produce a broad spectrum of material compositions and forms suitable for a variety of oyster species and estuarine environments.

Abstract: An embedded contact lens that comprises a lens body that has an anterior surface and an opposite posterior surface. The lens body is composed of a bulk hydrogel material and a circular insert embedded in the bulk hydrogel material and comprises an annular mask on the anterior surface or the posterior surface of the lens body. The circular insert comprises a peripheral edge. Both the annular mask and the insert are concentric with a central axis of the lens body. The annular mask is an opaque colored area that covers or overlaps the peripheral edge of the circular insert to minimize or eliminate optical disturbances induced by peripheral edge of the circular insert.

Abstract: A gaming device in accordance with some implementations includes a housing, a reel-spin initiation member, and a reel configured to spin in response to a user actuation of the reel-spin initiation member, the reel including a peripheral member having a plurality of symbols thereon and an array of light-emitting elements coupled to the reel. The gaming device also includes a controller coupled to the array of light-emitting elements and configured to selectively illuminate respective light-emitting elements of the array of light-emitting elements while the reel is rotating to produce an animated visual element.

Abstract: A method to detect noise levels in electrocardiogram (ECG) signals is provided. The method includes connecting to at least three sensing electrodes and obtaining a signal from each of the at least three sensing electrodes. The method also includes defining at least three channels between the at least three electrodes and obtaining heart data for a predetermined time period from the at least three channels wherein the heart data includes heart rate and QRS width. The method further includes comparing the heart data of each of the at least three channels to a consistency threshold.

Abstract: A turbomachine includes an annular casing and a fan disposed inside the annular casing and mounted for rotation about an axial centerline. The fan includes fan blades that extend radially outwardly toward the annular casing. The fan blades include a first fan blade having a fan blade airfoil body and a metal edge. The fan blade airfoil body has a leading edge. The metal edge is located at the leading edge and has a plurality of fail-fuse elements. The fan has an average chord fan width according to a first performance factor. The fan has a quantity of fan blades according to a second performance factor.

Abstract: The subject matter of this specification can be embodied in, among other things, an engine assembly having a nacelle surrounding an engine, and a thrust reverser coupled to the nacelle and having a thrust-reversing element movable relative to the nacelle between a stowed and deployed position, a first hydraulic actuator configured to move the thrust-reversing element between the stowed position and deployed position, the first hydraulic actuator being connected to a fluid source and a return reservoir, and a second hydraulic actuator configured to move the thrust-reversing element between the stowed and deployed position, the second hydraulic actuator being connected to the fluid source and the return reservoir, and a control system having an electrohydraulic servo valve operable to selectively route fluid between the fluid source, the second hydraulic actuator, and the return reservoir, and a controller configured to operate the electrohydraulic servo valve.

Abstract: A localization and flight planning system for a drone performing inventory management is disclosed. The system includes a drone with sensors, one or more machine-learned models, and controllers. The system is configured to obtain data indicating inventory items to be scanned by the drone. The sensors are configured to obtain sensor data indicative of a warehouse infrastructure within the warehouse environment. The system is further configured to identify objects of interest based on the sensor data and store information associated with the objects of interest in an onboard memory. The one or more models are configured to generate one or more location anchors based on the objects of interest and localize the drone within the warehouse environment. The system may be further configured to generate flight plans based on localizing drone within the warehouse. The controllers may be configured to control the drone by executing the flight plans.

Abstract: For high-performance “advanced imaging” applications, a synchronization signal (13), which is output by a playback device (14) or another data sink, such as a server application, is used to synchronize the chronological recording of an image stream (1) chronologically exactly with the playback of this image stream on the playback device and/or to synchronize the recording with an alternating illumination. Here, the synchronization signal (13) is used to trigger an image recording frequency of an image sensor (7) of an image recording system (23), by which the image stream is recorded. Furthermore, the synchronization signal can also be used to chronologically trigger a light source (21) of the image recording system, so that during the recording of the sequence of single images (2), an alternating illumination is obtainable, which is also synchronized with the recording of the single images and/or the image playback on the playback device.