Abstract: A method of preparing particles of a drug substance or diagnostic imaging agent which comprises grinding the drug substance or imaging agent in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced contamination.

Abstract: A packaging system for a pre-assembled suture anchor assembly of the sort comprising of a suture anchor, a length of suture threadingly engaging the suture anchor and a pair of surgical needles attached to the opposite ends of the length of suture. The packaging system includes a tubular element sized to receive and removably hold the pointed ends of the respective needles within its opposite ends, and an envelope including front and back pockets, a top flap and a belt-like portion which is deflectable outwardly from the exterior of the envelope. The envelope can be manipulated between (1) a totally open position wherein the envelope is a flat sheet, (2) a partially closed position wherein the suture anchor is engaged by the belt-like element against the exterior of the envelope, the suture is located in a coil within the front pocket and the needles joined by the tubular element are located in the back pocket, and (3) a totally closed position wherein the top flap is folded over the open ends of the pockets.