Patents by Inventor Josepha Eduarda Maria Francisca Leysen

Josepha Eduarda Maria Francisca Leysen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of nebivolol as an anti-atherogenic
    Patent number: 6075046
    Abstract: This invention relates to the use of an .alpha.,.alpha.'-iminobis(methylene)bis[2-chromanmethanol] derivative for the manufacture of a medicament for the therapeutic or prophylactic treatment of humans suffering from or prone to degenerative diseases and conditions of the vascular and nervous system which are associated with oxidative stress.
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: June 13, 2000
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Didier Robert Guy Gabriel de Chaffoy de Courcelles, Anne Simone Josephine Lesage, Josepha Eduarda Maria Francisca Leysen
  • Use of fused benzothiazoles as neuroprotectants
    Patent number: 5955485
    Abstract: The present invention is concerned with the method of using a 2,3-dihydro-imidazo?2,1-b!benzothiazole derivative for the manufacture of a medicament for the therapeutic or prophylactic treatment of humans suffering from ageing of, or degenerative diseases of the nervous and vascular system which are associated with oxidative stress.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: September 21, 1999
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Marc Joris De Brabander, Anne Simone Josephine Lesage, Josepha Eduarda Maria Francisca Leysen
  • Use of Nebivolol as an anti-atherogenic
    Patent number: 5874461
    Abstract: This invention relates to the use of an .alpha.,.alpha.'-iminobs(methylene)bis ?2-chromanmethanol! derivative for the manufacture of a medicament for the therapeutic or prophylactic treatment of humans suffering from or prone to degenerative diseases and conditions of the vascular and nervous system which are associated with oxidative stress.
    Type: Grant
    Filed: June 16, 1997
    Date of Patent: February 23, 1999
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Didier Robert Guy Gabriel de Chaffoy de Courcelles, Anne Simone Josephine Lesage, Josepha Eduarda Maria Francisca Leysen
  • 4-amino-n-(4-methyl-4-piperidinyl)-2-methoxybenzamides
    Patent number: 5691358
    Abstract: Piperidinyl substituted benzamides of formula ##STR1## the pharmaceutically acceptable acid addition salts thereof and the stereoisomeric forms thereof, wherein R.sup.1 is hydrogen or halo; R.sup.2 is halo; R.sup.3 is hydrogen or halo; R.sup.4 and R.sup.5 each independently are hydrogen, C.sub.1-4 alkyl or haloC.sub.1-4 alkyl; and the group NR.sup.4 R.sup.5 may also be azido, Alk is C.sub.2-4 alkanediyl; pharmaceutical compositions containing said compounds of formula (I) as active ingredient; use of said compounds as a medicine; process of preparing said compounds; compounds of formula (I) containing a radioactive isotope; process of marking 5HT.sub.2 -receptor sites; and process for imaging an organ are disclosed.
    Type: Grant
    Filed: October 27, 1995
    Date of Patent: November 25, 1997
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Josepha Eduarda Maria Francisca Leysen, Georges Henri Paul Van Daele
  • 4-amino-N-(4-methyl-4-piperidinyl)-2-methoxybenzamides
    Patent number: 5688814
    Abstract: Piperidinyl substituted benzamides of formula ##STR1## the pharmaceutically acceptable acid addition salts thereof and the stereoisomeric forms thereof, wherein R.sup.1 is hydrogen or halo; R.sup.2 is halo; R.sup.3 is hydrogen or halo; R.sup.4 and R.sup.5 each independently are hydrogen, C.sub.1-4 alkyl or haloC.sub.1-4 alkyl; and the group NR.sup.4 R.sup.5 may also be azido, Alk is C.sub.2-4 alkanediyl; pharmaceutical compositions containing said compounds of formula (I) as active ingredient; use of said compounds as a medicine; process of preparing said compounds; compounds of formula (I) containing a radioactive isotope; process of marking 5HT.sub.2 -receptor sites; and process for imaging an organ are disclosed.
    Type: Grant
    Filed: October 27, 1995
    Date of Patent: November 18, 1997
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Josepha Eduarda Maria Francisca Leysen, Georges Henri Paul Van Daele