Patents by Inventor Josephine GILES

Josephine GILES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for treating diseases associated with exhausted T cells
    Patent number: 11906511
    Abstract: The present invention provides compositions and methods for detecting exhausted T cells in a subject. The present invention also provides methods for treating a subject having a disease characterized by the presence of exhausted T cells or certain subpopulations thereof.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: February 20, 2024
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: E. John Wherry, Bertram Bengsch, Omar Khan, Jennifer Wu, Josephine Giles
  • MODULATION OF EXPRESSION OF GENES RELATED TO T CELL EXHAUSTION
    Publication number: 20220211759
    Abstract: The present invention provides methods of preventing, reducing or reversing T cell exhaustion in a patient having a disease. The present invention also provides methods for treating a disease in a patient having the disease. The present invention also provides an engineered T cell, and uses thereof.
    Type: Application
    Filed: May 1, 2020
    Publication date: July 7, 2022
    Inventors: E. John WHERRY, Omar KHAN, Josephine GILES
  • Methods and Compositions for Treating Diseases Associated with Exhausted T Cells
    Publication number: 20210033595
    Abstract: The present invention provides compositions and methods for detecting exhausted T cells in a subject. The present invention also provides methods for treating a subject having a disease characterized by the presence of exhausted T cells or certain subpopulations thereof.
    Type: Application
    Filed: October 26, 2018
    Publication date: February 4, 2021
    Inventors: E. John Wherry, Bertram BENGSCH, Omar KHAN, Jennifer WU, Josephine GILES