Patents by Inventor Josephine M. Egan

Josephine M. Egan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GLP-1, exendin-4, peptide analogs and uses thereof
    Patent number: 10941187
    Abstract: The invention relates to novel polypeptide analogs of GLP-1 and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. Preferably, the polypeptide's insulinotropic effect is comparable to or exceeds the effect of an equimolar amount of GLP-1 or exendin-4. The invention also relates to a method of treating a subject with diabetes, comprising administering to the subject the polypeptide of the invention in an amount that has an insulinotropic effect. The invention also relates to methods of using GLP-1, exendin-4, and polypeptide analogs thereof for neuroprotective and neurotrophic effects.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: March 9, 2021
    Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventors: Nigel H. Greig, Josephine M. Egan, Maire Doyle, Harold W. Holloway, Tracy Perry
  • GLP-1, EXENDIN-4, PEPTIDE ANALOGS AND USES THEREOF
    Publication number: 20150072930
    Abstract: The invention relates to novel polypeptide analogs of GLP-1 and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. Preferably, the polypeptide's insulinotropic effect is comparable to or exceeds the effect of an equimolar amount of GLP-1 or exendin-4. The invention also relates to a method of treating a subject with diabetes, comprising administering to the subject the polypeptide of the invention in an amount that has an insulinotropic effect. The invention also relates to methods of using GLP-1, exendin-4, and polypeptide analogs thereof for neuroprotective and neurotrophic effects.
    Type: Application
    Filed: August 27, 2014
    Publication date: March 12, 2015
    Inventors: Nigel H. Greig, Josephine M. Egan, Maire Doyle, Harold W. Holloway, Tracy Perry
  • GLP-1, exendin-4, peptide analogs and uses thereof
    Patent number: 8853160
    Abstract: The invention relates to novel polypeptide analogs of GLP-1 and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. Preferably, the polypeptide's insulinotropic effect is comparable to or exceeds the effect of an equimolar amount of GLP-1 or exendin-4. The invention also relates to a method of treating a subject with diabetes, comprising administering to the subject the polypeptide of the invention in an amount that has an insulinotropic effect. The invention also relates to methods of using GLP-1, exendin-4, and polypeptide analogs thereof for neuroprotective and neurotrophic effects.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: October 7, 2014
    Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventors: Nigel H. Greig, Josephine M. Egan, Maire Doyle, Harold W. Holloway, Tracy Perry
  • Uses of notch receptors, notch ligands, and notch modulators in methods related to metabolic diseases
    Patent number: 7888116
    Abstract: Disclosed are methods for identifying and isolating a precursor cell. Also, disclosed are methods of increasing insulin synthesis from a pancreatic B-cell. Further, disclosed are methods of improving pancreatic B-cell function. Still further, disclosed are methods of preventing or delaying the onset of a metabolic disease, methods of treating or preventing a metabolic disease in a subject, and to compositions for treating or preventing a metabolic disease in a subject in need of such treatment or prevention.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: February 15, 2011
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Josephine M. Egan, Máire E. Doyle
  • Uses of Notch Receptors, Notch Ligands, and Notch Modulators in Methods Related to Metabolic Diseases
    Publication number: 20080299088
    Abstract: Disclosed are methods for identifying and isolating a precursor cell. Also, disclosed are methods of increasing insulin synthesis from a pancreatic ?-cell. Further, disclosed are methods of improving pancreatic ?-cell function. Still further, disclosed are methods of preventing or delaying the onset of a metabolic disease, methods of treating or preventing a metabolic disease in a subject, and to compositions for treating or preventing a metabolic disease in a subject in need of such treatment or prevention.
    Type: Application
    Filed: July 22, 2005
    Publication date: December 4, 2008
    Inventors: Josephine M. Egan, Maire E. Doyle