Patents by Inventor Josephine R. Chandler

Josephine R. Chandler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bactobolin analog and synthesis method thereof
    Patent number: 8222434
    Abstract: The present inventions are directed to a novel bactobolin analog bactobolin D. The present inventions also are directed to a method of producing a composition comprising at least one bactobolin analog using a bacteria strain comprising a bacterial cell comprising the biosynthetic locus of the bactobolin analog in Burkholderia thailandensis (bta cluster) or a homolog structure (at least 95% sequence identity) thereof, and further isolation and purification of the bactobolin analog. For example, the bacterial strain can be a wild type bacterial strain such as a Burkholderia strain comprising a bta cluster (e.g. Burkholderia thailandensis (e.g. E264, Bt4, and TXDOH) and Burkholderia pseudomallei (e.g. K96243, 1106a, and 1106b).
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: July 17, 2012
    Assignees: University of Washington through its Center for Commercialization, President and Fellows of Harvard College
    Inventors: E. Peter Greenberg, Josephine R. Chandler, Breck Duerkop, Patricia Silva Lima, Joshua Alan Blodgett, Jon Clardy, Mohammad R. Seyedsayamdost