Patents by Inventor Josephu L. H. Van Gelder

Josephu L. H. Van Gelder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiretroviral tetrahydroimidazo[1,4]benzodiazepin-2(thi) ones
    Patent number: 6201119
    Abstract: The compounds are of the class 1,4-benzodiazepines of the formula: An illustrative compound is (S)-6-chloro-2,3,4,5-tetrahydro-3-methyl-4-(3-methyl-2-butenyl)-1H-1,4-benzodiazepin-9-amine. The compounds are useful as intermediates in the preparation of tetrahydroimidazo[1,4]benzodiazepin-2-(thi)ones.
    Type: Grant
    Filed: October 17, 1994
    Date of Patent: March 13, 2001
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Michael Joseph Kukla, Henry Joseph Breslin, Alfons H. M. Raeymaekers, Josephus L. H. Van Gelder, Paul Adriaan Jan Janssen
  • Antiretroviral tetrahydroimidazo[1,4]benzodiazepin-2-(thi)ones
    Patent number: 5371079
    Abstract: The compounds are of the class of tetrahydroimidazo[1,4]benzodiazepin-2-(thi)ones possessing antiretroviral, especially anti-HIV-1, activity. An illustrative compound is (+)-S-4,5,6,7-tetrahydro-9-chloro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4 ,5,1-jk][1,4]benzodiazepine-2(1H)-thione. These compounds are represented by the formula: ##STR1## The application also discloses compositions containing these compounds as active ingredients and methods of treating subjects suffering from retroviral infections by administering said compounds.
    Type: Grant
    Filed: October 5, 1993
    Date of Patent: December 6, 1994
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Michael J. Kukla, Henry J. Breslin, Alfons H. M. Raeymaekers, Josephus L. H. Van Gelder, Paul A. J. Janssen
  • Anti-HIV-1 tetrahydroimidazo[1,4]benzodiazepin-2-(thi) ones
    Patent number: 5270464
    Abstract: Novel tetrahydroimidazo[1,4]benzodiazepin-2-(thi)ones possessing anti-HIV-1 activity, compositions containing these compounds as active ingredients, and methods of treating subjects suffering from HIV-1 infection by administering these compounds.
    Type: Grant
    Filed: April 5, 1993
    Date of Patent: December 14, 1993
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Michael J. Kukla, Henry J. Breslin, Alfons H. M. Raeymaekers, Josephus L. H. Van Gelder, Paul A. J. Janssen
  • 6-(1H-azol-1-ylmethyl)-1-(pyrimidinyloxy)-1H benzotriazoles
    Patent number: 5039677
    Abstract: (1H-azol-1-ylmethyl)substituted benzotriazole derivatives, compositions containing the same, and methods of treating estrogen dependent disorders.
    Type: Grant
    Filed: June 13, 1990
    Date of Patent: August 13, 1991
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Alfons H. M. Raeymaekers, Eddy J. E. Freyne, Josephus L. H. Van Gelder, Marc G. Venet
  • (1H-azol-1-ylmethyl) substituted benzotriazole derivatives and pharmaceutical compositions containing them
    Patent number: 4943574
    Abstract: (1H-azol-1-ylmethyl)substituted benzotriazole derivatives, compositions containing the same, and methods of treating estrogen dependent disorders.
    Type: Grant
    Filed: September 28, 1989
    Date of Patent: July 24, 1990
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Alfons H. M. Raeymaekers, Eddy J. E. Freyne, Josephu L. H. Van Gelder, Marc G. Venet
  • 5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives
    Patent number: 4243806
    Abstract: Novel 5-[4-(diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives having antiallergic and antihistaminic properties.
    Type: Grant
    Filed: June 13, 1979
    Date of Patent: January 6, 1981
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Alfons H. M. Raeymaekers, Josephus L. H. Van Gelder, Gustaaf M. Boeckx, Lodewijk L. Van Hemeldonck
  • 5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives
    Patent number: 4179505
    Abstract: Novel 5-[4-(diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives having antiallergic and antihistaminic properties.
    Type: Grant
    Filed: January 4, 1978
    Date of Patent: December 18, 1979
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Alfons H. M. Raeymaekers, Josephus L. H. Van Gelder, Gustaaf M. Boeckx, Lodewijk L. Van Hemeldonck