Patents by Inventor Josephus C. Mertens

Josephus C. Mertens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antipsychotic 3-piperazinylbenzazole derivatives
    Patent number: 5015740
    Abstract: 3-Piperazinyl-1,2-benzazoles and their pharmaceutically acceptable acid addition salts having useful antipsychotic properties and being useful in the treatment of a variety of disorders in which serotonin and/or dopamine release is of predominant importance.
    Type: Grant
    Filed: June 11, 1990
    Date of Patent: May 14, 1991
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ludo E. J. Kennis, Jan Vandenberk, Josephus C. Mertens
  • Antipsychotic 3-piperazinylbenzazole derivatives
    Patent number: 4957916
    Abstract: 3-Piperazinyl-1,2-benzazoles and their pharmaceutically acceptable acid addition salts having useful antipsychotic properties and being useful in the treatment of a variety of disorders in which serotonin and/or dopamine release is of predominant importance.
    Type: Grant
    Filed: June 14, 1989
    Date of Patent: September 18, 1990
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ludo E. J. Kennis, Jan Vandenberk, Josephus C. Mertens
  • Derivatives of hydroxy- or amino-substituted (piperidinylalkyl)quinazolines
    Patent number: 4665075
    Abstract: Novel derivatives of hydroxy- or amino-substituted (piperidinylalkyl)quinazolines which are useful agents in the treatment of warmblooded animals suffering from diseases according to the vascular bed in which excessive serotonin release occurs.
    Type: Grant
    Filed: September 26, 1985
    Date of Patent: May 12, 1987
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Vandenberk, Ludo E. J. Kennis, Josephus C. Mertens
  • [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
    Patent number: 4581171
    Abstract: Novel [[bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones, wherein the pyrimidinone-ring is embraced within a bicyclic system, being useful compounds in the treatment of psychosomatic disorders.
    Type: Grant
    Filed: September 27, 1984
    Date of Patent: April 8, 1986
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Ludo E. J. Kennis, Jan Vandenberk, Josephus C. Mertens
  • 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds
    Patent number: 4548938
    Abstract: Novel 5H-thiazolo- and 5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one and 3,4-dihydro-2H,6H-pyrimido[2,1-b] [1,3]-thiazin-6-one derivatives, which compounds are useful psychotropic agents.
    Type: Grant
    Filed: February 19, 1985
    Date of Patent: October 22, 1985
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ludo E. J. Kennis, Josephus C. Mertens
  • [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
    Patent number: 4533665
    Abstract: Novel [[bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones, wherein the pyrimidinone-ring is embraced within a bicyclic system, being useful compounds in the treatment of psychosomatic disorders.
    Type: Grant
    Filed: September 27, 1984
    Date of Patent: August 6, 1985
    Assignee: Janssen Pharmaceutica
    Inventors: Ludo E. J. Kennis, Jan Vandenberk, Josephus C. Mertens
  • Pyrimido[2,1-b][1,3]-thiazines
    Patent number: 4529727
    Abstract: Novel 5H-thiazolo- and 5H-1,3,4-thiadiazolo[3,2-a]-pyrimidin-5-one and 3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3]-thiazin-6-one derivatives, which compounds are useful psychotropic agents.
    Type: Grant
    Filed: February 2, 1984
    Date of Patent: July 16, 1985
    Assignee: Janssen Pharmaceutical, N.V.
    Inventors: Ludo E. J. Kennis, Josephus C. Mertens
  • [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
    Patent number: 4485107
    Abstract: Novel [[bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones, wherein the pyrimidinone-ring is embraced within a bicyclic system, being useful compounds in the treatment of psychosomatic disorders.
    Type: Grant
    Filed: July 27, 1983
    Date of Patent: November 27, 1984
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ludo E. J. Kennis, Jan Vandenberk, Josephus C. Mertens
  • Bicyclic pyrimidin-5-one derivatives
    Patent number: 4443451
    Abstract: Novel 5H-thiazolo- and 5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one and 3,4-dihydro-2H,6H-pyrimido[2,1-b] [1,3]-thiazin-6-one derivatives, which compounds are useful psychotropic agents.
    Type: Grant
    Filed: April 21, 1982
    Date of Patent: April 17, 1984
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ludo E. J. Kennis, Josephus C. Mertens
  • Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
    Patent number: 4342870
    Abstract: Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives, wherein the piperidine ring is substituted with an aroyl radical or a functional derivative thereof, said compounds being potent serotonin-antagonists.
    Type: Grant
    Filed: September 29, 1980
    Date of Patent: August 3, 1982
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ludo E. J. Kennis, Josephus C. Mertens