Patents by Inventor Josephus J. M. Holthuis

Josephus J. M. Holthuis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lyophilized composition containing S(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)
    Patent number: 5760039
    Abstract: A process of making a stable lyophilized, white to off-white, crack-free preparation of ICRF-187 in which the cake of ICRF-187 is protected against the deleterious effect of light, has a moisture content of not more than about 2% wherein the process comprises lyophilization using a starting solution of a therapeutically acceptable acid salt of ICRF-187 having a concentration of up to about 25 mg/ml and in which the primary drying stage lasts at least 30 hours, preferably at least 40 hours, and/or uses a primary drying temperature of from about 30.degree. C. to about 40.degree. C.
    Type: Grant
    Filed: April 10, 1997
    Date of Patent: June 2, 1998
    Assignee: Chiron Corporation
    Inventors: Josephus J. M. Holthuis, Alwinus A. Voetman
  • Parathyroid hormone formulation
    Patent number: 5496801
    Abstract: Described herein are preparations containing parathyroid hormone that has been stablized with an excipient and buffering agent. Preferred preparations incorporate human PTH(1-84), mannitol as excipient and citrate as buffering agent, and are incorporated in vials as a freeze-dried powder for reconstitution to treat osteoporosis.
    Type: Grant
    Filed: December 23, 1993
    Date of Patent: March 5, 1996
    Assignee: Allelix BioPharmaceuticals Inc.
    Inventors: Josephus J. M. Holthuis, Albert Mekking, Alwinus A. Voetman