Abstract: In accordance with at least some embodiments of the present disclosure, a process for calculating patient-specific organ dose is presented. The process may include constructing a computed tomography (CT) volume based on CT images generated by a CT scanner. The process may include segmenting the CT volume into a plurality of organ regions, generating a material density map for the CT volume based on Hounsfield Unit (HU) values, and generating a dose distribution map for the CT volume based on the material density map by simulating particles emitting from the CT scanner and flowing through the CT volume. The process may further generate a dose value delivered to a specific organ region of the plurality of organ regions based on the dose distribution map.

Abstract: In a method of making pixelated scintillators, an amorphous scintillator material in a molten state is pressed into a plurality of cavities defined by a plurality of walls of a mesh array. The molten scintillator material in the plurality of cavities is cooled to form a pixelated scintillator array. An x-ray imager including a pixelated scintillator is also described.

Abstract: Reconstruction of projection images of a CBCT scan is performed by generating simulated projection data, comparing the simulated projection data to the projection images of the CBCT scan, determining a residual volume based on the comparison, and using the residual volume to determine an accurate reconstructed volume. The reconstructed volume can be used to segment a tumor (and potentially one or more organs) and align the tumor to a planning volume (e.g., from a CT scan) to identify changes, such as shape of the tumor and proximity of the tumor to an organ. These changes can be used to update a radiation therapy procedure, such as by altering a radiation treatment plan and fine-tuning a patient position.

Abstract: The present invention pertains to an apparatus for generating a charged particle beam comprising a magnetic element for controlling the profile of the beam in a predetermined plane. A cathode can be provided for emitting charged particles and an anode for accelerating the charged particles along an axis of travel. The present invention also pertains to a method for generating a particle beam that has a uniform profile in a predetermined plane comprising inducing emission of charged particles from an emitter, accelerating those particles along and toward an axis of beam travel, generating a magnetic field with a component aligned with the axis of beam travel but different in the predetermined plane than at the emitter, and modifying the beam profile.

Abstract: In accordance with at least some embodiments of the present disclosure, a process for calculating patient-specific organ dose is presented. The process may include constructing a computed tomography (CT) volume based on CT images generated by a CT scanner. The process may include segmenting the CT volume into a plurality of organ regions, generating a material density map for the CT volume based on Hounsfield Unit (HU) values, and generating a dose distribution map for the CT volume based on the material density map by simulating particles emitting from the CT scanner and flowing through the CT volume. The process may further generate a dose value delivered to a specific organ region of the plurality of organ regions based on the dose distribution map.

Abstract: The present invention pertains to an apparatus and method for X-ray imaging wherein a radiation source comprising rows of discrete emissive locations can be positioned such that these rows are angularly offset relative to rows of sensing elements on a radiation sensor. A processor can process and allocate responses of the sensing elements in appropriate memory locations given the angular offset between source and sensor. This manner of allocation can include allocating the responses into data rows associated with unique positions along a direction of columns of discrete emissive locations on the source. Mapping coefficients can be determined that map allocated responses into an image plane.

Abstract: The present invention pertains to an apparatus for generating a charged particle beam comprising a magnetic element for controlling the profile of the beam in a predetermined plane. A cathode can be provided for emitting charged particles and an anode for accelerating the charged particles along an axis of travel. The present invention also pertains to a method for generating a particle beam that has a uniform profile in a predetermined plane comprising inducing emission of charged particles from an emitter, accelerating those particles along and toward an axis of beam travel, generating a magnetic field with a component aligned with the axis of beam travel but different in the predetermined plane than at the emitter, and modifying the beam profile.

Abstract: In a method of making pixelated scintillators, an amorphous scintillator material in a molten state is pressed into a plurality of cavities defined by a plurality of walls of a mesh array. The molten scintillator material in the plurality of cavities is cooled to form a pixelated scintillator array. An x-ray imager including a pixelated scintillator is also described.

Abstract: The present invention pertains to an apparatus for generating a charged particle beam comprising a magnetic element for controlling the profile of the beam in a predetermined plane. A cathode can be provided for emitting charged particles and an anode for accelerating the charged particles along an axis of travel. The present invention also pertains to a method for generating a particle beam that has a uniform profile in a predetermined plane comprising inducing emission of charged particles from an emitter, accelerating those particles along and toward an axis of beam travel, generating a magnetic field with a component aligned with the axis of beam travel but different in the predetermined plane than at the emitter, and modifying the beam profile.

Abstract: One example method for estimating scatter associated with a target object may include acquiring a set of original projection data that includes primary radiation and scattered radiation at one or more selected projection angles associated with the target object, generating a first set of estimated scatter data from the set of original projection data, generating reconstructed image data by performing a first pass reconstruction using the first set of estimated scatter data, and generating a set of reference scatter data associated with the target based on the reconstructed image data. The example method may also include generating a set of reference primary plus scatter data associated with the target object based on the reconstructed image data, generating a second set of estimated scatter data associated with the target object based on the set of reference primary plus scatter data, and generating perturbation data associated with the target object.

Abstract: An imaging method includes obtaining a first image data for a subset of a target region, the subset of the target region having a first metallic object, obtaining a second image data for the target region, and using the first and second image data to determine a composite image. A imaging system includes a first detector configured to provide a first projection data using a first radiation having high energy, and a second detector configured to provide a second projection data using a second radiation having low energy, wherein the first detector has a first length, the second detector has a second length, and the first length is less than 75% of the second length.

Abstract: The present invention pertains to an apparatus and method for X-ray imaging wherein a radiation source comprising rows of discrete emissive locations can be positioned such that these rows are angularly offset relative to rows of sensing elements on a radiation sensor. A processor can process and allocate responses of the sensing elements in appropriate memory locations given the angular offset between source and sensor. This manner of allocation can include allocating the responses into data rows associated with unique positions along a direction of columns of discrete emissive locations on the source. Mapping coefficients can be determined that map allocated responses into an image plane.

Abstract: Techniques described herein generally relate to estimating scatter. In one embodiment, one example method for estimating scatter associated with a target object may include generating a set of original projections associated with the target object, generating a set of reference scatter data associated with the target object at one or more selected projection angles, generating a first set of estimated scatter data associated with the target object also at the one or more selected projection angles, adjusting first values for one or more kernel parameters of one or more kernels that reduce a difference between the set of reference scatter data and the first set of estimated scatter data, interpolating the adjusted first values for remaining projections out of the set of original projections to generate second values for the one or more kernel parameters, and generating a second set of estimated scatter data associated with the target object.

Abstract: The present invention pertains to an apparatus and method for X-ray imaging wherein a radiation source comprising rows of discrete emissive locations can be positioned such that these rows are angularly offset relative to rows of sensing elements on a radiation sensor. A processor can process and allocate responses of the sensing elements in appropriate memory locations given the angular offset between source and sensor. This manner of allocation can include allocating the responses into data rows associated with unique positions along a direction of columns of discrete emissive locations on the source. Mapping coefficients can be determined that map allocated responses into an image plane.

Abstract: Methods and systems for scanning objects comprising scanning a portion of an object by a first radiation beam having a first value of a beam characteristic, such as the dose, and detecting the first radiation beam after interaction with the object by a first detector. It is determined whether to change the first value to a second value based, at least in part, on the detected first radiation beam. That portion of the object is then scanned by a second radiation beam having the first value or the second value based on the determination. The second radiation is detected after interacting with the object by a second detector. The second detector may have a second resolution greater than a first resolution of the first detector. The first and second radiation beams may be formed by first and second slots angled with respect to each other.

Abstract: Techniques described herein generally relate to estimating scatter. In one embodiment, one example method for estimating scatter associated with a target object may include generating a set of original projections associated with the target object, generating a set of reference scatter data associated with the target object at one or more selected projection angles, generating a first set of estimated scatter data associated with the target object also at the one or more selected projection angles, adjusting first values for one or more kernel parameters of one or more kernels that reduce a difference between the set of reference scatter data and the first set of estimated scatter data, interpolating the adjusted first values for remaining projections out of the set of original projections to generate second values for the one or more kernel parameters, and generating a second set of estimated scatter data associated with the target object.

Abstract: Methods and systems for scanning objects comprising scanning a portion of an object by a first radiation beam having a first value of a beam characteristic, such as the dose, and detecting the first radiation beam after interaction with the object by a first detector. It is determined whether to change the first value to a second value based, at least in part, on the detected first radiation beam. That portion of the object is then scanned by a second radiation beam having the first value or the second value based on the determination. The second radiation is detected after interacting with the object by a second detector. The second detector may have a second resolution greater than a first resolution of the first detector. The first and second radiation beams may be formed by first and second slots angled with respect to each other.

Abstract: Embodiments of the disclosure generally set forth techniques for adjusting an estimate of scattered radiation of a target object. One example method includes generating a plurality of radiographic projections, selecting a first radiographic projection and a second radiographic projection of the target object from the plurality of radiographic projections, forming first estimates of scattered radiation in the first and second radiographic projections, applying the first estimates of scattered radiation to the first and second radiographic projections to generate a modified first radiographic projection and a modified second radiographic projection, comparing the modified first and second radiographic projections to generate correction modules, and applying one of the correction modules to a first subset of the plurality of radiographic projections and another of the correction modules to a second subset of the plurality of radiographic projections.

Abstract: The claimed subject matter describes a novel technique to measure the beam profile using an area detector. In one embodiment, a set of one-dimensional beam profile measurements is performed by taking two images under the same source conditions but at two different positions of the detector, with each position of the detector shifted by a certain distance in the direction corresponding to the direction of the one-dimensional profile measurement. In further embodiments, a set of two-dimensional beam profile measurements is achieved by determining a second set of one-dimensional profiles from the same sampling points in a second direction and building a two-dimensional map of the beam profile by correlating the first one-dimensional profile measurement with the second one-dimensional profile measurement.

Abstract: In accordance with at least some embodiments of the present disclosure, a process for enhancing an image is presented. The process may include receiving a first plurality of projections, wherein the first plurality of projections contain computed tomography (CT) data obtained in multiple motion phases and also image data attributable to a first portion of a scanned object. The process may include expanding the first plurality of projections to cover at least the first portion of the scanned object to generate a second plurality of projections. The process may further include generating a phase-correlated image based on a multi-phase image and a phase-correlated difference image, wherein the multi-phase image is reconstructed based on the second plurality of projections, and the phase-correlated difference image is reconstructed based on the first plurality of projections and the second plurality of projections.