Abstract: An occupancy grid determination method includes: determining a predicted occupancy grid based on a previous occupancy grid, the predicted occupancy grid comprising a plurality of first cells corresponding to sub-regions of a region, each of the plurality of first cells including a plurality of predicted indications of probability each indicative of a predicted probability of a respective possible type of occupier of the respective first cell; determining, using machine learning and based on the first sensor measurements, an observed occupancy grid comprising a plurality of second cells corresponding to the sub-regions of the region; and determining an updated occupancy grid based on the observed occupancy grid and the predicted occupancy grid.

Abstract: An occupancy grid probability prediction method includes: determining a dynamic particle probability based on a first probability that a dynamic particle will move from a donor cell of an occupancy grid to a recipient cell of the occupancy grid; and determining one or more predicted probabilities of at least one of the donor cell or the recipient cell based on the dynamic particle probability.

Abstract: An occupancy map processing method includes: obtaining an occupancy map of a region comprising a plurality of cells, corresponding to sub-regions, each including an occupancy indication indicative of occupier type of the sub-region, and the plurality of cells comprising delimiter cells and non-delimiter cells; and providing, from the apparatus, occupancy information comprising first occupancy information corresponding to the delimiter cells and either second occupancy information corresponding to fewer than all of the non-delimiter cells or no second occupancy information.

Abstract: The invention provides compositions and methods for treatment of sleep disorders. Such methods entail administering to the patient a therapeutically effective dosage regime of an agonist of a hypocretin 1 (Hcrt-1) receptor to a peripheral tissue of the patient, and monitoring the condition of the patient responsive to the treatment, wherein the monitoring indicates a reduction in excessive daytime sleepiness (EDS) and an improvement in nighttime sleep consolidation and architecture. The methods are particularly useful for prophylactic and therapeutic treatment of one or more sleep disorders in a patient.

Abstract: The invention provides compositions and methods for treatment of sleep disorders. Such methods entail administering to the patient a therapeutically effective dosage regime of an agonist of a hypocretin 1 (Hcrt-1) receptor to a peripheral tissue of the patient, and monitoring the condition of the patient responsive to the treatment, wherein the monitoring indicates a reduction in excessive daytime sleepiness (EDS) and an improvement in nighttime sleep consolidation and architecture. The methods are particularly useful for prophylactic and therapeutic treatment of one or more sleep disorders in a patient.

Abstract: The invention provides compositions and methods for treatment of sleep disorders. Such methods entail administering to the patient a therapeutically effective dosage regime of an agonist of a hypocretin 1 (Hcrt-1) receptor to a peripheral tissue of the patient, and monitoring the condition of the patient responsive to the treatment, wherein the monitoring indicates a reduction in excessive daytime sleepiness (EDS) and an improvement in nighttime sleep consolidation and architecture. The methods are particularly useful for prophylactic and therapeutic treatment of one or more sleep disorders in a patient.