Patents by Inventor Joshua A. Bittker

Joshua A. Bittker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selective inhibition of gluconeogenic activity
    Patent number: 11247970
    Abstract: The present invention provides compounds, pharmaceutical compositions and methods for treating and/or preventing a metabolic condition, such as diabetes.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: February 15, 2022
    Assignees: Dana-Farber Cancer Institute, Inc., The Scripps Research Institute, The Broad Institute, Inc.
    Inventors: Pere Puigserver, Kfir Sharabi, Theodore Kamenecka, Patrick Griffin, Stuart L. Schreiber, Roger Schilling, Partha P. Nag, Joshua A. Bittker
  • SELECTIVE INHIBITION OF GLUCONEOGENIC ACTIVITY
    Publication number: 20200317620
    Abstract: The present invention provides compounds, pharmaceutical compositions and methods for treating and/or preventing a metabolic condition, such as diabetes.
    Type: Application
    Filed: March 21, 2018
    Publication date: October 8, 2020
    Applicants: Dana-Farber Cancer Institute, Inc., The Scripps Research Institute
    Inventors: Pere PUIGSERVER, Kfir SHARABI, Theodore KAMENECKA, Patrick GRIFFIN, Stuart L. SCHREIBER, Roger SCHILLING, Partha P. NAG, Joshua A. BITTKER
  • Turn over probes and use thereof for nucleic acid detection
    Patent number: 7968289
    Abstract: The invention provides turnover probes for use in a variety of detection assays, for example, nucleic acid detection assays. In addition, the invention provides assays, for example, nucleic acid detection assays, using such turnover probes.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: June 28, 2011
    Assignee: Ensemble Therapeutics Corporation
    Inventors: James M. Coull, Lawrence A. Haff, Joshua A. Bittker, Xiaoyu Li, Larry W. McLaughlin
  • Directed evolution of proteins
    Patent number: 7807408
    Abstract: Disclosed is a method of altering a nucleic acid such as RNA or DNA. The method comprises fragmenting a parent nucleic acid strand to generate nucleic acid fragments. At least a subset of the fragments are ligated to generate shuffled nucleic acid strands. A selected strand is identified from the shuffled nucleic acid strands for a criterion. The methods of the invention can also be used to diversify proteins.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: October 5, 2010
    Assignee: President & Fellows of Harvard College
    Inventors: David R. Liu, Joshua A. Bittker, Jane M. Liu
  • Nucleic acid shuffling
    Patent number: 7678554
    Abstract: Disclosed is a method of altering a nucleic acid. The method includes fragmenting a parent nucleic acid strand to generate nucleic acid fragments. At least a subset of the fragments are ligated to generate shuffled nucleic acid strands. A selected strand is identified from the shuffled nucleic acid strands for a criterion.
    Type: Grant
    Filed: March 19, 2002
    Date of Patent: March 16, 2010
    Assignee: President and Fellows of Harvard College
    Inventors: David R. Liu, Joshua A. Bittker
  • Turn Over Probes and Use Thereof for Nucleic Acid Detection
    Publication number: 20090280477
    Abstract: The invention provides turnover probes for use in a variety of detection assays, for example, nucleic acid detection assays. In addition, the invention provides assays, for example, nucleic acid detection assays, using such turnover probes.
    Type: Application
    Filed: May 3, 2006
    Publication date: November 12, 2009
    Inventors: James M. Coull, Lawrence A. Haff, Joshua A. Bittker, Xiaoyu Li, Alexander F. Rosenberg, Larry W. McLaughlin
  • Analysis of Encoded Chemical Libraries
    Publication number: 20090005256
    Abstract: The invention provides methods and compositions for analysis of a mixture of DNA sequences. More particularly, the invention provides methods and compositions for analysis of encoded chemical libraries having encoding nucleic acid tags (e.g., encoded chemical libraries prepared by nucleic acid-mediated chemistry) through analyzing the nucleic acid templates.
    Type: Application
    Filed: July 28, 2006
    Publication date: January 1, 2009
    Inventors: Joshua A. Bittker, James M. Coull, Edward M. Driggers
  • Directed evolution of proteins
    Publication number: 20050260655
    Abstract: Disclosed is a method of altering a nucleic acid such as RNA or DNA. The method comprises fragmenting a parent nucleic acid strand to generate nucleic acid fragments. At least a subset of the fragments are ligated to generate shuffled nucleic acid strands. A selected strand is identified from the shuffled nucleic acid strands for a criterion. The methods of the invention can also be used to diversify proteins.
    Type: Application
    Filed: April 15, 2005
    Publication date: November 24, 2005
    Inventors: David Liu, Joshua Bittker, Jane Liu
  • Nucleic acid shuffling
    Publication number: 20030027180
    Abstract: Disclosed is a method of altering a nucleic acid. The method includes fragmenting a parent nucleic acid strand to generate nucleic acid fragments. At least a subset of the fragments are ligated to generate shuffled nucleic acid strands. A selected strand is identified from the shuffled nucleic acid strands for a criterion.
    Type: Application
    Filed: March 19, 2002
    Publication date: February 6, 2003
    Inventors: David R. Liu, Joshua A. Bittker