Patents by Inventor Joshua A. Imperatore

Joshua A. Imperatore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MICRO RNA INTERACTIONS AS THERAPEUTIC TARGETS FOR COVID-19 AND OTHER VIRAL INFECTIONS
    Publication number: 20220119812
    Abstract: Provided is an agent that binds to a SARS-CoV-2 s2m motif, a SARS-CoV-2 3?-UTR Terminus, or a SARS-CoV-2 DIS-s2m extended sequence. Provided is a method of treating an infection in a subject, comprising: administering a therapeutically effective amount of the agent to the subject. In some embodiments, the infection is SARS-CoV-2 infection.
    Type: Application
    Filed: October 20, 2021
    Publication date: April 21, 2022
    Inventors: Mihaela Rita Mihailescu, Jeffrey D. Evanseck, Joshua A. Imperatore, Kendy Anne Marie Guarinoni, Caylee Lyne Cunningham, Caleb James Frye, Adam Henry Kensinger
  • AN RNA G-QUADRUPLEX STRUCTURE IN PRE-miRNA-1229 AS A THERAPEUTIC TARGET FOR ALZHEIMER'S DISEASE AND VARIOUS CANCERS
    Publication number: 20210340537
    Abstract: Provided is an agent that binds to a wild type or variant pre-miRNA-1229 comprising a G-quadruplex (GQ) structure, wherein binding of the agent to the wild type or variant pre-miRNA-1229 stabilizes the GQ structure of the wild type or variant pre-miRNA-1229. In some embodiments, the variant is rs2291418. Provided is a method of treating a disease in a subject, comprising: administering a therapeutically effective amount of the agent to the subject. In some embodiments, the disease is Alzheimer's disease, cancer or coronary artery calcification.
    Type: Application
    Filed: April 15, 2021
    Publication date: November 4, 2021
    Inventors: Mihaela Rita Mihailescu, Joshua A. Imperatore