Patents by Inventor Joshua A. Kritzer

Joshua A. Kritzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic peptide epitopes and small-molecule mimics for inducing autophagy
    Patent number: 10993983
    Abstract: Disclosed herein are cyclic peptides that induce cellular autophagy and have significant cell penetration activity. Methods for inducing autophagy and thereby treating various diseases and conditions associated with impaired autophagy are provided.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: May 4, 2021
    Assignees: Trustees of Tufts College, Board of Regents of the University of Texas System
    Inventors: Joshua Kritzer, Beth Levine, Leila Peraro
  • Chloroalkane penetration method for quantifying access of a molecule into a cell
    Patent number: 10620214
    Abstract: As described below, the invention provides methods for localizing and quantifying the extent to which a molecule penetrates a cell.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: April 14, 2020
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: Joshua Kritzer, Leila Peraro
  • CYCLIC PEPTIDE EPITOPES AND SMALL-MOLECULE MIMICS FOR INDUCING AUTOPHAGY
    Publication number: 20190382443
    Abstract: Disclosed herein are cyclic peptides that induce cellular autophagy and have significant cell penetration activity. Methods for inducing autophagy and thereby treating various diseases and conditions associated with impaired autophagy are provided.
    Type: Application
    Filed: March 17, 2017
    Publication date: December 19, 2019
    Applicants: TRUSTEES OF TUFTS COLLEGE, BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: JOSHUA KRITZER, BETH LEVINE, LEILA PERARO
  • METHOD OF QUANTIFYING CELL PENETRATION OF A MOLECULE
    Publication number: 20180188260
    Abstract: As described below, the invention provides methods for localizing and quantifying the extent to which a molecule penetrates a cell.
    Type: Application
    Filed: November 20, 2017
    Publication date: July 5, 2018
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: JOSHUA KRITZER, LEILA PERARO
  • ?-peptides
    Patent number: 8008262
    Abstract: ?-peptide regions of polypeptides can serve as structural mimics of ?-helices in wild type proteins. Because ?-helices of one protein often bind to a target protein in a biological pathway, a polypeptide that contains a helical ?-peptide region can be used to disrupt this type of protein-protein binding. As a result, polypeptides that contain a helical ?-peptide region can be used to treat conditions involving this type of protein-protein binding, such as viral infections and cell proliferation.
    Type: Grant
    Filed: April 21, 2005
    Date of Patent: August 30, 2011
    Assignee: Yale University
    Inventors: Alanna Schepartz Shrader, Scott A. Hart, Joshua A. Kritzer, Olen M. Stephens
  • MODIFIED MINIATURE PROTEINS
    Publication number: 20100273722
    Abstract: The present invention generally relates to modified miniature proteins, including modified avian pancreatic polypeptides (aPP) and modified pancreatic peptide YYs (PYY). One aspect of the invention is generally directed to various aPPs that have been modified such that they do not substantially form multimers in solution, for example through the addition of a proline switch. Another aspect of the invention is generally directed to modified PYYs, such as YY3. Yet another aspect of the invention is generally directed to composites of modified miniature proteins formed from portions of different miniature proteins such as aPP and/or PYY, optionally with a proline switch. Still other aspects of the invention are generally directed to methods of making such proteins, methods of using such proteins, kits involving such proteins, and the like.
    Type: Application
    Filed: April 16, 2008
    Publication date: October 28, 2010
    Applicant: Yale University
    Inventors: Alanna Shrader Schepartz, Abby M. Hodges, Crystal Zellofrow, Joshua A. Kritzer
  • Beta-peptides
    Publication number: 20050277592
    Abstract: ?-peptide regions of polypeptides can serve as structural mimics of ?-helices in wild type proteins. Because ?-helices of one protein often bind to a target protein in a biological pathway, a polypeptide that contains a helical ?-peptide region can be used to disrupt this type of protein-protein binding. As a result, polypeptides that contain a helical ?-peptide region can be used to treat conditions involving this type of protein-protein binding, such as viral infections and cell proliferation.
    Type: Application
    Filed: April 21, 2005
    Publication date: December 15, 2005
    Applicant: Yale University
    Inventors: Alanna Shrader, Scott Hart, Joshua Kritzer, Olen Stephens