Abstract: Medical devices described herein include a melt-pressed film having first and second diffusion barrier layers disposed thereon. The melt-pressed film and the barrier layers comprise bioabsorbable copolymers. In a further aspect, a therapeutic agent, such as an analgesic is included in the medical device.

Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

Abstract: A surgical portal apparatus includes a sleeve having a proximal end and a distal end that extends along a longitudinal axis, and a surgical tape. The sleeve includes an inner wall defining an internal longitudinal passageway dimensioned for permitting passage of a surgical object therethrough and an outer wall configured for positioning against tissue. The inner and outer walls define at least a partial annular space therebetween, the annular space being in fluid communication with an opening in the outer wall. The surgical tape includes a body portion retained within the annular space of the sleeve and a leading tab extendable through the opening in the outer wall of the sleeve. The surgical tape has a first surface and a second surface, each of the first and second surfaces having at least one of tissue reactive functional groups and self-reactive functional groups.

Abstract: Surgical visualization devices are provided which include a substrate having at least one imaging device and a plurality of fasteners coupled thereto for attaching the substrate to patient tissue. Systems and methods utilizing the surgical visualization devices are also provided.

Abstract: The present disclosure relates to a medical device and methods of making the same. The medical device includes a porous substrate and at least one film. The film is formed within the pore of the substrate. The film is intra-porous and does not contact adjacent pores or films.

Abstract: An apparatus for supporting tissue during compression prior to the insertion of a surgical element into the tissue has a substrate. The substrate is made from a predetermined material. The predetermined material has a thickness and a predetermined stress strain profile. The predetermined stress strain profile is complementary to a stress strain profile of the tissue and permits the substrate to support the tissue when the surgical element is delivered into the tissue. The substrate provides hemostasis control of the tissue when the surgical element is delivered into the tissue.

Abstract: Medical devices having more than one degradation zone or degradation mechanism are used for orthopedic repair devices and soft tissue fixation devices.

Abstract: The present disclosure relates to applicators designed for controlled in situ delivery of therapeutic films or depots during a surgical procedure.

Abstract: A surgical portal apparatus includes a sleeve having a proximal end and a distal end that extends along a longitudinal axis, and a surgical tape. The sleeve includes an inner wall defining an internal longitudinal passageway dimensioned for permitting passage of a surgical object therethrough and an outer wall configured for positioning against tissue. The inner and outer walls define at least a partial annular space therebetween, the annular space being in fluid communication with an opening in the outer wall. The surgical tape includes a body portion retained within the annular space of the sleeve and a leading tab extendable through the opening in the outer wall of the sleeve. The surgical tape has a first surface and a second surface, each of the first and second surfaces having at least one of tissue reactive functional groups and self-reactive functional groups.

Abstract: The present disclosure relates to implantable medical devices containing a polymeric film layer containing glycerol and at least one biopolymer.

Abstract: The present disclosure is directed to an implantable repository including a housing comprising at least one bioactive agent and at least one attachment member coupled to the housing, the at least one attachment member configured to couple the implantable repository to at least one of a medical device and a tissue surface.

Abstract: Oral dosage forms for the delivery of therapeutic agents include mechanical fasteners for engaging tissue of the gastrointestinal tract.

Abstract: Medical devices having a wound closure device and a reinforcing material are reacted in situ to create a self-sealing implant.

Abstract: A medical device for wound closure, including an elongate body with a plurality of portions and a perforated region disposed therebetween. The medical device may also include an alignment member. The wound plug may also have a first position for insertion, the portions being mechanically coupled to each other, and a second position where one or more of the portions are spatially separated.

Abstract: Oral dosage forms for the delivery of therapeutic agents include mechanical fasteners for engaging tissue of the gastrointestinal tract.

Abstract: The invention relates a sheath that is affixed to a body lumen, proximal to an anastomosis site. The sheath includes a sleeve defining a passage. A grasping structure is positioned distally of the distal opening of the sheath to facilitate elongation of the sleeve from a first length to a second longer length. A method for using the sheath is also disclosed.

Abstract: The present disclosure relates to implantable medical devices which include at least one mesh and at least one film pivotably attached to the mesh.

Abstract: The present disclosure provides a package for a medical device having a surface prepared for receiving a target agent and a port for permitting the passage of the target agent between the surface of the medical device contained therein.

Abstract: A wound closure device for repairing perforations and tissue wall defects is disclosed herein. The wound closure device has a barbed elongate body and a plug member. The wound closure device may further include a foam structure. The wound closure device may also include an inner member which may be a tissue scaffold. A method for closing tissue is also disclosed.

Abstract: A sheath is configured for elongation from a first length to a second, longer length and a retention member retains the sheath at the first length. A portion of the retention member is removed or disengaged, the sheath is released and expands in situ to the second longer length. A method for releasing the retention member is also disclosed.