Patents by Inventor Joshua Aden Welsh

Joshua Aden Welsh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIOMARKER ANALYSIS FOR HIGH-THROUGHPUT DIAGNOSTIC MULTIPLEX DATA
    Publication number: 20210025878
    Abstract: Flow cytometry of extracellular vesicle (EV) samples produces counts associated with channels defined by combinations of capture agents and detection agents, typically capture antibodies and detection antibodies having associated markers such as fluorophores. Sample groupings are obtained by processing channel counts using principal component analysis or other techniques. Identification of a particular sample grouping permits selection of associated channels for detection of samples exhibiting characteristics of the particular sample grouping.
    Type: Application
    Filed: March 29, 2019
    Publication date: January 28, 2021
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Joshua Aden Welsh, Jennifer C. Jones, Jay A. Berzofsky
  • Optical configuration methods for spectral scatter flow cytometry
    Patent number: 10876955
    Abstract: Apparatus include an illumination source configured to produce and direct a multi-wavelength illumination beam to a microfluidic target that can include nanotags, a detector configured to receive a multi-wavelength detection beam from the microfluidic target and to produce a detection signal, wherein the multi-wavelength detection beam comprises light that is elastically side-scattered by an interaction between the multi-wavelength illumination beam and the nanotags in the microfluidic target, and a processor configured to receive the detection signal and to determine the presence of the nanotags in the microfluidic target by comparing multiple wavelength side-scatter intensity characteristics of the detection signal with predetermined multi-wavelength elastic side-scatter intensity profiles of one or more nanotag types.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: December 29, 2020
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Joshua Aden Welsh, Jennifer C. Jones, William G. Telford, Jay A. Berzofsky, Ari Rosner
  • OPTICAL CONFIGURATION METHODS FOR SPECTRAL SCATTER FLOW CYTOMETRY
    Publication number: 20200278285
    Abstract: Apparatus include an illumination source configured to produce and direct a multi-wavelength illumination beam to a microfluidic target that can include nanotags, a detector configured to receive a multi-wavelength detection beam from the microfluidic target and to produce a detection signal, wherein the multi-wavelength detection beam comprises light that is elastically side-scattered by an interaction between the multi-wavelength illumination beam and the nanotags in the microfluidic target, and a processor configured to receive the detection signal and to determine the presence of the nanotags in the microfluidic target by comparing multiple wavelength side-scatter intensity characteristics of the detection signal with predetermined multi-wavelength elastic side-scatter intensity profiles of one or more nanotag types.
    Type: Application
    Filed: October 23, 2018
    Publication date: September 3, 2020
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servi
    Inventors: Jay A. Berzofsky, Jennifer C. Jones, Joshua Aden Welsh, William G. Telford, Ari Rosner