Abstract: Provided herein are conjugates comprising proteins that bind to a transferrin receptor and oligonucleotides that are capable of modulating the expression of a target gene or sequence, as well as methods of use thereof.

Abstract: The techniques described herein relate to prosthesis assembly including a baseplate with a medial/lateral midline extending between a medial compartment and a lateral compartment and a keel extending distally from the distal surface to define a longitudinal keel axis. The longitudinal keel axis is medially biased toward the medial compartment so as to be spaced a first distance medial of the medial/lateral midline. The prosthesis assembly includes a hinge post having an longitudinal axis, the hinge post received in a recess in the baseplate including in the keel.

Abstract: A prosthesis assembly can include a tibial tray, a tibial bearing component, a hinge post, a femoral component, a shackle, walls, a hinge axle, and a bump stop. The hinge post can extend through the tibial bearing component and be at least partially received in a recess of the tibial tray. The femoral component can contact an articular surface of the tibial bearing component. The shackle can be coupled to the hinge post and configured to be inserted between a medial and a lateral condyle of the femoral component. The walls can be positioned between the femoral component and the shackle. The hinge axle can be configured to secure the femoral component to the shackle. The bump stop can be removably attached to the femoral component and configured to contact the shackle at a set limit of rotation of the femoral component relative to the tibial bearing component.

Abstract: A prosthesis assembly may include a femoral component, a tibial bearing component engaged by the femoral component and a tibial baseplate. The prosthesis assembly may include a hinge post coupled to the femoral component and at least partially received in a recess in the tibial baseplate. The prosthesis assembly may include a bushing received in a recess in the tibial baseplate. The hinge post is at least partially received by the bushing and the bushing includes one or more engagement features configured to couple the bushing to the hinge post.

Abstract: A prosthesis system may include a femoral component, a tibial bearing component configured to articulate with the femoral component, a baseplate, a plurality of bushings, one or more hinge posts and a capture element. The capture element can be configured to couple with the baseplate and can have a thru hole configured to allow at least a portion of the one or more hinge posts to pass therethrough. When coupled to the baseplate, the capture element is configured to be engaged by at least one of the plurality of bushings or one of the one or more hinge posts to limit distraction of the femoral component from the tibial bearing component and baseplate.

Abstract: A tibial implant comprises a tibial tray component comprising a tray plate with proximal and distal surfaces, a stem and a segmented keel extending from the distal surface, the segmented keel including a first wing having a first notch proximate the stem, and a first taper extending along the stem in a first axial position axially aligned with the segmented keel. A sleeve for a stem of a prosthetic implant comprises an annular body, an inner passage extending through the annular body, the inner passage comprising a Morse taper, and a first slot extending into the annular body to intersect the inner passage and the Morse taper. A method comprises fabricating a stemmed prosthetic component from a metallic material, advancing a machining tool into a notch in a keel wing extending from the stem, and forming a Morse taper on the stem with the machining tool in the notch.

Abstract: The techniques described herein relate to a prosthesis assembly. The prosthesis assembly may include a femoral component, a tibial bearing component engaged by the femoral component and a tibial baseplate. The tibial baseplate can include a bushing received in a recess in the tibial baseplate and a hinge post coupled to the femoral component and the bushing. The hinge post can be at least partially received by the bushing. A prosthesis assembly may include a capture element coupled to the tibial baseplate. The capture element can be engaged by at least one of the bushing or the hinge post to limit distraction of the femoral component from the tibial bearing component and tibial baseplate.

Abstract: Disclosed herein are polycyclic aromatic compound embodiments and methods of making and using such compounds. In some embodiments, the polycyclic aromatic compounds comprise an indenoindenodi(benzothiophene) skeleton. The polycyclic aromatic compound embodiments can be used in a variety of devices, such as electronic and/or electrooptical devices.

Abstract: Disclosed herein are polycyclic aromatic compound embodiments and methods of making and using such compounds. In some embodiments, the polycyclic aromatic compounds comprise an indenoindenodi(benzothiophene) skeleton. The polycyclic aromatic compound embodiments can be used in a variety of devices, such as electronic and/or electrooptical devices.