Patents by Inventor Joshua Barry Cohen

Joshua Barry Cohen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ISOQUINOLINE DERIVATIVES AS INHIBITORS OF BAX AND/OR BAK, COMPOSITIONS AND USES THEREOF
    Publication number: 20250154140
    Abstract: The present application relates to isoquinoline compounds of Formula (I), to processes for their preparation and to compositions comprising them. More particularly, the present application relates to compound of Formula (I) that have activity as inhibitors of Bcl2-associated X protein (BAX) and/or Bcl-2 antagonist killer (BAK), and to their use in the treatment of diseases, disorders or conditions treatable by inhibiting BAX and/or BAK such as neurodegenerative diseases, disorders or conditions.
    Type: Application
    Filed: February 17, 2023
    Publication date: May 15, 2025
    Applicants: Sunnybrook Research Institute, Ontario Institute for Cancer Research (OICR)
    Inventors: David Andrews, Justin Kale, Justin Pogmore, Rima Al-Awar, Methvin Isaac, Gennady Poda, David Uehling, Tao Xin, Joshua Barry Cohen, Bridget McCarthy Cole
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF VARIOUS DISEASES
    Publication number: 20250032514
    Abstract: Provided herein are methods and compositions for treating a neurodegenerative disease (e.g., PSP). The methods can include administering to the subject a bile acid or a pharmaceutically acceptable salt thereof and a phenylbutyrate compound.
    Type: Application
    Filed: July 23, 2024
    Publication date: January 30, 2025
    Inventors: Joshua Barry Cohen, Justin Bernard Klee, Mathias Leinders, Lahar Mehta
  • OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
    Publication number: 20240102017
    Abstract: Among other things, the present disclosure provides oligonucleotides targeting calpain-2 and compositions thereof. In some embodiments, the present disclosure provides methods for preventing or treating various conditions, disorders or diseases.
    Type: Application
    Filed: May 9, 2023
    Publication date: March 28, 2024
    Inventors: Joshua Barry Cohen, Justin Bernard Klee, Duncan Brown
  • OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
    Publication number: 20240102018
    Abstract: Among other things, the present disclosure provides oligonucleotides targeting SARM1 and compositions thereof. In some embodiments, the present disclosure provides methods for preventing or treating various conditions, disorders or diseases.
    Type: Application
    Filed: July 21, 2023
    Publication date: March 28, 2024
    Inventors: Joshua Barry Cohen, Justin Bernard Klee, Duncan Brown, Evan James Mizerak