Abstract: A system and method of effectively measuring a change in a gradient of a magnetic field. The systems include a first magnet and a second magnet mechanically coupled together and aligned along a polarization axis. The first magnet and the second magnet are positioned such that a pair of like magnetic poles of the first magnet and the second magnet face in opposite directions. Further, the first magnet and the second magnet are configured to move along the polarization axis in response to a magnetic field. A sensing system is configured to measure a change in a gradient of the magnetic field based on the movement of the first magnet and second magnet along the polarization axis in response to the magnetic field.

Abstract: A system and method for authentication of objects, which includes directing a laser beam onto a surface of an object to induce a thermoelastic excitation in bulk material of the object without altering the surface of the object, wherein the laser beam is pulsed. A surface ultrasonic wave at the surface of the object caused by the thermoelastic excitation is detected using a detector. A detection signal is generated using the detected surface ultrasonic wave. Digital data is generated using the detection signal. Authenticity of the object is determined by comparing the digital data and reference data stored in a database.

Abstract: An exemplary embodiment of the present invention provides an exosuit support system, comprising first and second orthotic interfaces, first and second members, and first and second actuators. The first and second orthotic interfaces can be configured to attach to left and right legs of a user, respectively. The first member can comprise a first end connected to the first orthotic interface and a second end connected to a portion of the system configured to be positioned proximate a right shoulder of the user. The second member can comprise a first end connected to the second orthotic interface and a second end connected to a portion of the system configured to be positioned proximate a left shoulder of the user. The first actuator can be configured to apply a first tension to the first member. The second actuator can be configured to apply a second tension to the second member.

Abstract: The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3? or GSK3?) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychiatric disorders, metabolic disorders, and cancer.

Abstract: An actuator system is provided having a fluidic body member having a surface configured to be deformable in response to a pressure differential. One or more auxetic elements are disposed on and engage the surface of the fluidic body member in the form of a network of beam elements. The auxetic element has a negative Poisson's ratio resulting in kinematics such that upon application of the internal fluid pressure, the surface of the fluidic body member is caused to have specific kinematics enabling planar and 3D motions. In some embodiments, the plurality of non-auxetic elements cooperate with a plurality of auxetic elements.

Abstract: The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

Abstract: The present technology generally relates to stopped-flow microfluidic devices. Select embodiments of the present technology include microfluidic devices having a first porous element configured to receive a first fluid and a second porous element configured to receive a second fluid. The second porous element can have one or more legs overlapping with the first porous element. The device can be configured such that (a) delivery of the first fluid to the first porous element causes the first fluid to flow along the length of the first porous element without substantially wetting the one or more legs, and (b) delivery of the second fluid to the second porous element causes the second fluid to flow into the overlapping regions of the first porous element, thereby substantially stopping flow of the first fluid along at least a portion of the first porous element.

Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a porous receiving element having an input region and a receiving region, a first fluid source and a second fluid source positioned within the input region of the receiving element; wherein the first fluid source is positioned between the second fluid source and the receiving region, and wherein, when both the first and second fluid sources are in fluid connection with the input region, the device is configured to sequentially deliver the first fluid and the second fluid to the receiving region without leakage.

Abstract: The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3? or GSK3?) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychiatric disorders, metabolic disorders, and cancer.

Abstract: A system and method for authentication of objects, which includes directing a laser beam onto a surface of an object to induce a thermoelastic excitation in bulk material of the object without altering the surface of the object, wherein the laser beam is pulsed. A surface ultrasonic wave at the surface of the object caused by the thermoelastic excitation is detected using a detector. A detection signal is generated using the detected surface ultrasonic wave. Digital data is generated using the detection signal. Authenticity of the object is determined by comparing the digital data and reference data stored in a database.

Abstract: An actuator system is provided having a fluidic body member having a surface configured to be deformable in response to a pressure differential. One or more auxetic elements are disposed on and engage the surface of the fluidic body member in the form of a network of beam elements. The auxetic element has a negative Poisson's ratio resulting in kinematics such that upon application of the internal fluid pressure, the surface of the fluidic body member is caused to have specific kinematics enabling planar and 3D motions. In some embodiments, the plurality of non-auxetic elements cooperate with a plurality of auxetic elements.

Abstract: An air purification system to remove dust and other particulate matter from passing air is disclosed. The air purification system includes a housing. The housing includes a plurality of vents provided. Further, the housing includes an opening provided at a bottom of the housing. The air purification system includes a door hingedly coupled to the housing. Further, the air purification system includes an air filter removably inserted into the housing through the opening. The air filter is aligned with the plurality of vents. The door is closed to form a closed structure with the housing. The air filter is used to filter air passing through the plurality of vents and to collect dust and particulate matter. The air purification system is used as a standalone device such as forced air heating and air conditioning system or as an accessory to an existing forced air heating and air conditioning systems.

Abstract: Temperature-actuated valves, devices including temperature-actuated valves, and related methods are described. In an embodiment, the temperature-actuated valve includes a heat-shrink film defining a perforation extending at least partially in a first direction. In an embodiment, the temperature-actuated valve is configured to open when a portion of the heat-shrink film including the perforation is heated above a threshold temperature to contract the heat-shrink film along a second direction perpendicular to the first direction to define an aperture, in an open configuration, providing a fluid a path through the heat-shrink film. In an embodiment, the temperature-actuated valve includes a leakage-mitigation feature configured to limit fluid flow through the perforation when the valve is in a closed configuration.

Abstract: An air purification system including a vent cover assembly and an air filter assembly is disclosed. The vent cover assembly includes a vent cover with a slot that permits access to an interior of the vent cover. The vent cover is retrofitted to existing air vents to allow filtering of air in a desired room. The air filter assembly includes a filter holder having an air filter removably attached thereto. The air filter is used to remove dust and other particle from the air flowing out of the air vents. The filter holder is removably mounted within vent cover, through the slot, with the air filter attached. The air flow out from the air vents, through the air filter and out of the vent cover into the desired room. The air in particular rooms is filtered with the air filter to help improve the health of the users.

Abstract: The present invention relates to a flood irrigation apparatus. The apparatus comprises a headgate in communication with a body of water. The body of water can be a pond or a reservoir, for example. The apparatus further comprises a conduit securely connected to the headgate and in fluid communication with the headgate, wherein the flow of water within the conduit is regulated by the operation of the headgate. The apparatus further comprises an exit chamber securely connected to the conduit and in fluid communication with the conduit. The exit chamber comprises a plurality of vertical bricks disposed on the floor of the exit chamber. The vertical bricks facilitate the trapping of the silt and debris on the floor of the exit chamber in order to provide substantially silt-free water for irrigation.

Abstract: The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3? or GSK3?) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychriatic disorders, metabolic disorders, and cancer.

Abstract: Temperature-actuated valves, devices including temperature-actuated valves, and related methods are described. In an embodiment, the temperature-actuated valve includes a heat-shrink film defining a perforation extending at least partially in a first direction. In an embodiment, the temperature-actuated valve is configured to open when a portion of the heat-shrink film including the perforation is heated above a threshold temperature to contract the heat-shrink film along a second direction perpendicular to the first direction to define an aperture, in an open configuration, providing a fluid a path through the heat-shrink film. In an embodiment, the temperature-actuated valve includes a leakage-mitigation feature configured to limit fluid flow through the perforation when the valve is in a closed configuration.

Abstract: The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. heptacellular carcinoma. In some embodiments, the present invention discloses the use of a small-molecule compound of formula (I)-(XXVI) and (III?) as disclosed herein to inhibit transcription factor Late SV40 Factor (LSF) for treatment of cancer, e.g., HCC.

Abstract: The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3? or GSK3?) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychriatic disorders, metabolic disorders, and cancer.

Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a porous receiving element having an input region and a receiving region, a first fluid source and a second fluid source positioned within the input region of the receiving element; wherein the first fluid source is positioned between the second fluid source and the receiving region, and wherein, when both the first and second fluid sources are in fluid connection with the input region, the device is configured to sequentially deliver the first fluid and the second fluid to the receiving region without leakage.