Abstract: Systems and methods of the present disclosure enable variable and dynamic feedback to electronic activities by receiving event data and utilizing a feedback machine learning model to predict an average feedback attribute and an average feedback variability attribute based on the event data. A feedback data entry is added to a user profile to store the average feedback attribute and the average feedback variability attribute. A new event and a new event attribute are received for the user profile, and a feedback probability distribution for the new event is generated based on the new event attribute, the average feedback attribute, and the average feedback variability attribute. A new event feedback is generated for the new event based on a random selection from the feedback probability distribution and is output to a computing device associated with the user profile.

Abstract: The disclosure concerns a method for patient stratification and selection of patients who are candidates for a specific therapy is described which is based on quantifying one or more digital image analysis feature distributions from stained tissue. The method extends beyond the abilities of a manual observer and a microscope, and generally comprises: acquiring digital images of stained tissue sections from patients submitted for evaluation, applying an algorithm process to said images with a computer to extract the morphometric and staining features of image pixels and tissue objects, deriving one or more distribution function for one or more image analysis features, calculating a summary statistic of the one or more distribution functions, and using said summary statistic along with an associated predefined patient stratification paradigm to separate a patient cohort into distinct strata which correspond to a decision to include or exclude a patient for a specific therapy.

Abstract: The disclosure concerns a method for patient stratification and selection of patients who are candidates for a specific therapy is described which is based on quantifying one or more digital image analysis feature distributions from stained tissue. The method extends beyond the abilities of a manual observer and a microscope, and generally comprises: acquiring digital images of stained tissue sections from patients submitted for evaluation, applying an algorithm process to said images with a computer to extract the morphometric and staining features of image pixels and tissue objects, deriving one or more distribution function for one or more image analysis features, calculating a summary statistic of the one or more distribution functions, and using said summary statistic along with an associated predefined patient stratification paradigm to separate a patient cohort into distinct strata which correspond to a decision to include or exclude a patient for a specific therapy.