Abstract: An area isolation system (AIS) is provided. The AIS may include a barrier adjacent to a work area, a barrier control panel (BCP) operatively connected to and disposed proximate the barrier, the BCP including a BCP controller in communication with a BCP short-range transceiver, the BCP controller configured to control the barrier, and a machine configured to autonomously operate within the work area. The machine may include a remote shutdown module (RSM) having an RSM controller in communication with an RSM short-range transceiver, and an RSM unique identifier preprogrammed into a memory associated with the RSM controller. The RSM short-range transceiver may be configured to send signals indicative of the RSM unique identifier to the BCP short-range transceiver when a machine radio zone associated with the RSM short-range transceiver intercepts with a BCP radio zone associated with the BCP short-range transceiver.