Abstract: A computing system includes a server. The server is communicatively coupled to a data repository and is configured to store a data in the data repository. The server is further configured to create, via a visual information flow creation tool, at least one information flow object, wherein the at least one information flow object comprises a flow, a sub-flow, an Action, or a combination thereof. The server is also configured to interface with the at least one information flow object via a front-end application programing interface (API), a back-end API, or a combination thereof. The server is additionally configured to execute the at least one information flow object via the front-end API, the back-end API, or a combination thereof, and to retrieve results obtained by executing the at least one information flow object via the front-end API, the back-end API, or the combination thereof.

Abstract: Provided herein are epigenetic-modifying DNA-targeting systems, such as CRISPR-Cas/guide RNA (gRNA) systems, for the transcriptional repression of Hepatitis B viral (HBV) genes to promote a cellular phenotype that leads to the reduction of HBV infection. In some embodiments, the epigenetic-modifying DNA-targeting systems bind to or target a target site of at least one gene or regulatory element thereof in a Hepatitis B viral DNA sequence in cell. In some aspects, the provided systems relate to the transcriptional repression of one or more Hepatitis B viral gene and/or regulatory element thereof. In some aspects, also provided herein are methods and uses related to the provided compositions, for example in repressing Hepatitis B viral replication and expression in connection with Hepatitis B infections.

Abstract: Provided herein are epigenetic-modifying DNA-targeting systems, such as CRISPR-Cas/guide RNA (gRNA) systems, for the transcriptional repression of Hepatitis B viral (HBV) genes to promote a cellular phenotype that leads to the reduction of HBV infection. In some embodiments, the epigenetic-modifying DNA-targeting systems bind to or target a target site of at least one gene or regulatory element thereof in a Hepatitis B viral DNA sequence in cell. In some aspects, the provided systems relate to the transcriptional repression of one or more Hepatitis B viral gene and/or regulatory element thereof. In some aspects, also provided herein are methods and uses related to the provided compositions, for example in repressing Hepatitis B viral replication and expression in connection with Hepatitis B infections.

Abstract: Systems and techniques for determining a trajectory for use in controlling a vehicle are described. A trajectory determination system may generate a variety of trajectories for potential use in controlling a vehicle, including a maximum braking trajectory that enables the maximum application of the vehicle's brakes. A vehicle computing system may determine a distance between vehicle and an obstacle and stopping distances for the various trajectories and implement the maximum braking trajectory after determining that the distance to stop for that trajectory is the same as, but not substantially greater than, the distance between the vehicle and the obstacle.

Abstract: A robotic surgical system includes a robotic manipulator that includes a mounting fixture defining a longitudinal channel, and a surgical tool removably coupleable to the mounting fixture. The surgical tool including a tool housing matable with the mounting fixture, an elongate shaft extending from the tool housing and receivable within the channel, and a latching mechanism provided on the elongate shaft and comprising one or more retention tabs biased radially outward with one or more biasing members. The one or more retention tabs are movable between a deployed state, where the one or more retention tabs protrude radially outward through a corresponding one or more slots to engage the mounting fixture, and a retracted state, where the one or more retention tabs are urged radially inward through the one or more slots to disengage the mounting fixture.

Abstract: A remote-controlled vehicle includes a vehicle body, a first wheel, a second wheel, and a camera mount. The vehicle body includes a carrying coupling. The first wheel is rotatably coupled to a first side of the vehicle body, and the second wheel is rotatably coupled to a second side of the vehicle body. Each of the first wheel and the second wheel has a first height measured in a direction perpendicular to a central longitudinal plane of the vehicle body. The camera mount is coupled to the vehicle body, and the camera mount is configured to removably couple to a camera device. The camera mount has a second height measured in the direction perpendicular to the central longitudinal plane, and the second height is less than the first height such that the camera mount does not extend outside of the first height.

Abstract: An artery can be occluded by implanting an occlusion implant within a subintimal space within a wall of the artery. As an example, a catheter having a side port just proximal of an inflatable balloon disposed near a distal end of the catheter can be advanced through the artery to a site at which an occlusion is desired. The inflatable balloon can be inflated and a guidewire can be advanced through a lumen of the catheter, out of the side port and into a subintimal space of the artery, with the inflated inflatable balloon guiding the guidewire towards the artery wall. An occlusion implant can be advanced over the guidewire into the subintimal space and the guidewire can be withdrawn, leaving the occlusion implant positioned within the subintimal space.

Abstract: A remote-controlled vehicle includes a vehicle body, a first wheel, a second wheel, and a camera mount. The first wheel is rotatably coupled to a first side of the vehicle body, and the second wheel is rotatably coupled to a second side of the vehicle body. Each of the first wheel and the second wheel has a first height measured in a direction perpendicular to a central longitudinal plane of the vehicle body. The camera mount is coupled to the vehicle body, and the camera mount is configured to removably couple to a camera device. The camera mount has a second height measured in the direction perpendicular to the central longitudinal plane, and the second height is less than the first height such that the camera mount does not extend outside of the first height.

Abstract: A surgical visualization system is disclosed. The surgical visualization system is configured to identify one or more structure(s) and/or determine one or more distances with respect to obscuring tissue and/or the identified structure(s). The surgical visualization system can facilitate avoidance of the identified structure(s) by a surgical device. The surgical visualization system can comprise a first emitter configured to emit a plurality of tissue-penetrating light waves and a second emitter configured to emit structured light onto the surface of tissue. The surgical visualization system can also include an image sensor configured to detect reflected visible light, tissue-penetrating light, and/or structured light. The surgical visualization system can convey information to one or more clinicians regarding the position of one or more hidden identified structures and/or provide one or more proximity indicators.

Abstract: Controls systems and methods are provided for controlling a surgical clip applier for applying surgical clips to a vessel, duct, shunt, etc., during a surgical procedure are provided. In an exemplary embodiment, a control system is provided for controlling at least one motor coupled to a drive system on a surgical clip applier device for driving one or more drive assemblies and thereby actuating one or more actuation assemblies. The control system can be configured to communicate with the drive system of the clip applier tool and to control and modify movement of one or more drive assemblies and actuation assemblies based on certain feedback.

Abstract: A remote-controlled vehicle includes a vehicle body, a first wheel, a second wheel, and a camera mount. The first wheel is rotatably coupled to a first side of the vehicle body, and the second wheel is rotatably coupled to a second side of the vehicle body. Each of the first wheel and the second wheel has a first height measured in a direction perpendicular to a central longitudinal plane of the vehicle body. The camera mount is coupled to the vehicle body, and the camera mount is configured to removably couple to a camera device. The camera mount has a second height measured in the direction perpendicular to the central longitudinal plane, and the second height is less than the first height such that the camera mount does not extend outside of the first height.

Abstract: A cutter wheel includes a drive plate having a first side and a second side opposite the first side. A wear plate is coupled to the first side of the drive plate for rotation with the drive plate. First and second cutters are coupled to the wear plate such that the wear plate is at least partially between the first side of the drive plate and the first and second cutters. Each cutter includes a cutter tip and a fastener-mounting aperture. A first fastener extends through the fastener-mounting aperture of the first cutter, through a first fastener-receiving aperture in the wear plate, and into a first aperture in the drive plate. A second fastener extends through the fastener-mounting aperture of the second cutter, through a respective fastener-receiving aperture in the wear plate, and into a respective aperture in the drive plate.

Abstract: Systems, computer program products, and methods are described herein for implementing predictive resource transfers. The present invention is configured to initiate a remote access to a computing device associated with a merchant; request, via the remote access, information associated with one or more resources associated with the merchant; electronically receive information associated with one or more historical resource transfers executed by one or more users within a predetermined distance from a location of the merchant; predict the market need for the one or more resources associated with the merchant based on at least initiating the machine learning engine on the one or more historical resource transfers; and generate one or more resource transfer requests associated with at least a subset of the one or more resources associated with the merchant based on at least the market need.

Abstract: A mold clamping system for exothermic reaction welding adapted to be power-operated by a power device, the combination comprising a first member adapted to support a first mold portion; a second member adapted to support a second mold portion; and a drive mechanism, adapted to be coupled to the power device, coupled to at least one of said first and second members and capable of moving the first and second members between a first position, in which the first and second mold portions are spaced apart, and a second position, in which the first and second mold portions are engaged, upon actuation of the power device in a first and a second direction, respectively.

Abstract: A cutter includes a first end configured to engage an object along a dominant force vector, a second end opposite the first end, a first side, and a second side opposite the first side. The cutter further includes an outer side, an inner side, and an aperture extending from the outer side to the inner side along a fastener axis that is substantially perpendicular to the dominant force vector. The cutter also includes a cutter tip on the first end and having a first cutting edge, a second cutting edge, and a third cutting edge, the cutting edges defining therebetween a cutting face. The cutting face defines a cutting swath having a width between the first cutting edge and the second cutting edge as the cutter rotates with the apparatus. No portion of the first side or the second side extends outside the width of the cutting swath.

Abstract: Surgical systems and methods are provided for controlling actuation and movement of various surgical devices.

Abstract: A robotic surgical system includes a robotic manipulator that includes a mounting fixture defining a longitudinal channel, and a surgical tool removably coupleable to the mounting fixture. The surgical tool including a tool housing matable with the mounting fixture, an elongate shaft extending from the tool housing and receivable within the channel, and a latching mechanism provided on the elongate shaft and comprising one or more retention tabs biased radially outward with one or more biasing members. The one or more retention tabs are movable between a deployed state, where the one or more retention tabs protrude radially outward through a corresponding one or more slots to engage the mounting fixture, and a retracted state, where the one or more retention tabs are urged radially inward through the one or more slots to disengage the mounting fixture.