Patents by Inventor Joshua Doloff

Joshua Doloff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biocompatible coatings and hydrogels for reducing foreign body response and fibrosis
    Patent number: 10730983
    Abstract: Zwitterionic polymers or biocompatible polymers with improved properties for cell encapsulation, coating of devices, or a combination thereof are described. The biocompatible polymer contains a zwitterionic monomer, a monomer with a reactive side chain, and optionally another hydrophobic monomer or a neutral hydrophilic monomer. The zwitterionic polymers are cross-linked with a cross-linker via covalent bond to form a zwitterionic hydrogel in the presence of cells. Also provided, are methods of making and using the zwitterionic polymers.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: August 4, 2020
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Omid Veiseh, Volkan Yesilyurt, Arturo Vegas, Joshua Doloff, Daniel G. Anderson, Robert S. Langer
  • SURFACE-COATED CONTINUOUS GLUCOSE MONITORS
    Publication number: 20200008718
    Abstract: CGMs containing a sensor electrode that is partially or completely coated with one or more layers of a material containing zwitterionic polymers are disclosed. With just a single calibration after implantation, CGMs containing the zwitterionic polymer coatings show reduced discordance between detected and actual blood glucose levels, during the crucial first one to three days, where current commercially available CGMs tend to show discordance with actual blood glucose levels.
    Type: Application
    Filed: June 13, 2017
    Publication date: January 9, 2020
    Applicants: Massachusetts Institute of Technology, The Children's Medical Center Corporation
    Inventors: Joshua DOLOFF, Xi XIE, Volkan YESILYURT, Omid VEISEH, Atieh SADRAEI, Daniel G. ANDERSON, Robert S. LANGER
  • BIOCOMPATIBLE COATINGS AND HYDROGELS FOR REDUCING FOREIGN BODY RESPONSE AND FIBROSIS
    Publication number: 20170355799
    Abstract: Zwitterionic polymers or biocompatible polymers with improved properties for cell encapsulation, coating of devices, or a combination thereof are described. The biocompatible polymer contains a zwitterionic monomer, a monomer with a reactive side chain, and optionally another hydrophobic monomer or a neutral hydrophilic monomer. The zwitterionic polymers are cross-linked with a cross-linker via covalent bond to form a zwitterionic hydrogel in the presence of cells. Also provided, are methods of making and using the zwitterionic polymers.
    Type: Application
    Filed: June 13, 2017
    Publication date: December 14, 2017
    Inventors: Omid Veiseh, Volkan Yesilyurt, Arturo Vegas, Joshua Doloff, Daniel G. Anderson, Robert S. Langer