Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: A compound having the following structure of Formula (I): or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R5, A, B, X, and Y are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

Abstract: Systems, methods, and computer storage media for generating a virtual workspace that references online media content of interest, facilitates re-visitation of encountered instances of content, and shares those instances with other software applications are provided. Upon receiving an indication that an online media content item has been selected, at least a reference thereto is copied to a virtual workspace where it may be accessed at a later time. The virtual workspace may be organized into content collections via the use of reference groupings, folders, categories, tags, labels, and the like and may be accessible in the context of a plurality of applications. In embodiments, the virtual workspace is associated with a display area that is presented concurrently with an application being utilized so that the virtual workspace may be accessed and utilized without leaving the context of an active application.

Abstract: The distributed game system disclosed herein provides for interacting play between multiple users, even though the users are interconnected with a host computer through a data communication network having appreciable latency. The host computer supports a program for tracking and coordinating the definitive state of the game. The computers employed by each of the users support at least two types of program components, a display component and an interaction component. The interaction component is responsive to at least two kinds of user input, goal input which identifies user proxy movement within a virtual world and impact input which identifies direct interaction between the inputting user's proxy and the proxy of an identified other user. Goal input is interpreted by the host computer which distributes to all users information defining a plan of movement for the inputting user's proxy.