Abstract: An agricultural sprayer includes tubular main frame rails supporting tank and plumbing structure. A tank port is located between the rails with a substantial portion of the plumbing structure supported between the rails and between the upper and lower planes of the rails for protection and a neat appearance. The upright walls of the rails include round holes reinforced with round tube secured to the walls to seal the wall and prevent contaminants from entering the rails. The round tube is split to allow torsional frame flexibility while preventing high stress at the round tube sidewall connections. A straight horizontal fluid line path between the port and a location outside the frame is provided through the round tube to limit line length, eliminate elbows, improve appearance, improve cleanout functions and facilitate a low mounting of the tank on the frame.