Abstract: Techniques are described herein for authenticating a plurality of components of a user equipment to enable one or more functionalities of the components. The techniques include receiving a component identifier corresponding to a hardware component of the user equipment; verifying that the component identifier matches a network record in a data store, the network record corresponding to the hardware component; enabling one or more functionalities of the user equipment, based at least in part on verifying the component identifier with the network record; and activating the hardware component for use on the user equipment via a communications network.

Abstract: Techniques are described herein for remotely managing profiles corresponding to various mobile network operators offering telecommunication services to target user equipment based on one or more policies. The techniques include loading at least one profile on an embedded UICC (eUICC) of a user equipment, the one of profiles including a prioritized profile. The techniques also include receiving a request that includes an embedded UICC identifier (EID) and an integrated circuit card identifier (ICCID) corresponding to the eUICC of the user equipment, wherein the request is for locking one or more functionalities of the user equipment. One or more policies are retrieved for locking the one or more functionalities from a policy database. Based at least on the one or more policies, locking instructions are sent to the user equipment. The instructions include instructions to enable the prioritized profile.

Abstract: Techniques are described herein for remotely managing profiles corresponding to various mobile network operators offering telecommunication services to target user equipment based on one or more policies. The techniques include loading at least one profile on an embedded UICC (eUICC) of a user equipment, the one of profiles including a prioritized profile. The techniques also include receiving a request that includes an embedded UICC identifier (EID) and an integrated circuit card identifier (ICCID) corresponding to the eUICC of the user equipment, wherein the request is for locking one or more functionalities of the user equipment. One or more policies are retrieved for locking the one or more functionalities from a policy database. Based at least on the one or more policies, locking instructions are sent to the user equipment. The instructions include instructions to enable the prioritized profile.

Abstract: A user device may be authorized to access a telecommunications network, such as a cellular network, after completing a boot process that includes a device activation phase and a network activation phase. An application resident on the user device initiates, in the device activation phase, a device eligibility check over a secondary communication network such as a WLAN. Device eligibility may be determined by whether the user device was legitimately sold. If the user device fails the eligibility check, the boot process is stopped, rendering the user device inactive. If the user device passes the eligibility check, the application initiates the network activation phase in which the user device is checked against a blacklist. If the user device is blacklisted, the boot process is shut down. If the user device is not blacklisted, the boot process completes normally.

Abstract: Techniques are described herein for remotely managing profiles corresponding to various mobile network operators offering telecommunication services to target user equipment based on one or more policies. An entitlement server of a mobile network operator can receive from target user equipment, a request for replacing a prioritized profile as set by the mobile network operator. The entitlement server can determine whether a user account corresponding to a device identifier for the target user equipment meets the eligibility criteria for loading a new profile onto the target user equipment. In the event of additions or replacements of profiles, the entitlement server can cause transmission of instructions to the user equipment to delete the prioritized profile and apply a new profile.

Abstract: Techniques are disclosed for cooling an unmanned aerial vehicle (UAV). In some examples, a heat sink is coupled to a portion of the UAV that is to be cooled. One or more heat pipes are coupled to the shim, and extend to one or more propulsion engines of the UAV. Liquid in a heat pipe is heated to gaseous form at the heat sink, and the vapor travels to a portion of the heat pipe near the propulsion engine, where the vapor is cooled by air moved by the propulsion engine, upon which the vapor returns to liquid form and travels back to the heat sink.

Abstract: The systems, devices, and methods discussed herein are directed to a network for delivering to portable communication devices, or user equipment (UEs) subscribed to the network, an update for an install service, such as software and firmware, via a hybrid transport mechanism. The hybrid transport mechanism comprises initially broadcasting the update to multiple UEs simultaneously, then re-broadcasting, multicasting, multiple unicasting, and/or transmitting via a wireless local area network (WLAN), the update to a group of UEs that missed the initial broadcast and/or needing file repairs.

Abstract: The systems, devices, and methods discussed herein are directed to a network for delivering to portable communication devices, or user equipment (UEs) subscribed to the network, an update for an install service, such as software and firmware, via a hybrid transport mechanism. The hybrid transport mechanism comprises initially broadcasting the update to multiple UEs simultaneously, then re-broadcasting, multicasting, multiple unicasting, and/or transmitting via a wireless local area network (WLAN), the update to a group of UEs that missed the initial broadcast and/or needing file repairs.

Abstract: The systems, devices, and methods discussed herein are directed to a network for delivering to portable communication devices, or user equipment (UEs) subscribed to the network, an update for an install service, such as software and firmware, via a hybrid transport mechanism. The hybrid transport mechanism comprises initially broadcasting the update to multiple UEs simultaneously, then re-broadcasting, multicasting, multiple unicasting, and/or transmitting via a wireless local area network (WLAN), the update to a group of UEs that missed the initial broadcast and/or needing file repairs.

Abstract: Systems and methods are described herein for authorizing master resets (e.g., factory resets) of mobile devices, such as smart phones, tablets, and so on. In some embodiments, the systems and methods employ a server-based authorization schema or mechanism, where at least one step or operation is performed, or caused to be performed, by a server or other system that is remote from the mobile device being reset.

Abstract: Compounds, compositions and methods are provided for modulating the expression of RANKL. The compositions comprise oligonucleotides, targeted to nucleic acid encoding RANKL. Methods of using these compounds for modulation of RANKL expression and for diagnosis and treatment of disease associated with expression of RANKL are provided.

Abstract: The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

Abstract: The present invention describes a newly discovered polynucleotide encoding a protein involved in the cell signaling cascade, called RET16, cloned, isolated and identified from TNF-alpha stimulated human microvascular endothelial cells, as well as mouse and rat RET16 orthologs thereof. Also described are the RET16 polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the human RET16 protein, and use of the RET16 polynucleotide and polypeptide for therapeutics and diagnostics are described.

Abstract: The present invention describes a newly discovered polynucleotide encoding a protein involved in the cell signaling cascade, called RET16, cloned, isolated and identified from TNF-alpha stimulated human microvascular endothelial cells, as well as mouse and rat RET16 orthologs thereof. Also described are the RET16 polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the human RET16 protein, and use of the RET16 polynucleotide and polypeptide for therapeutics and diagnostics are described.

Abstract: The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

Abstract: The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

Abstract: The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of a bone growth modulator in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.

Abstract: The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

Abstract: Compounds, compositions and methods are provided for modulating the expression of RANKL. The compositions comprise oligonucleotides, targeted to nucleic acid encoding RANKL. Methods of using these compounds for modulation of RANKL expression and for diagnosis and treatment of disease associated with expression of RANKL are provided.