Abstract: The present invention provides multispecific antibodies comprising a Fab region and an Fc region, wherein the Fab region comprises a binding site specific for an epitope of the variable delta 1 (V?1) chain of a ?? T cell receptor (TCR); and the Fc region comprises an EGFR binding site. The present invention also provides compositions and pharmaceutical compositions comprising such multispecific antibodies, and method of making such multispecific antibodies. The present invention also provides methods of treatment and medical uses involving the multispecific antibodies.

Abstract: A radiotherapy device is provided comprising a radiation source, an MR imaging apparatus and a controller. The radiation source is configured to generate a radiotherapy beam for irradiating a subject. The MR imaging apparatus is configured to apply a 3D MR pulse sequence to obtain k-space data for the subject. The controller is communicatively coupled to the radiation source and the MR imaging apparatus and is configured to select central k-space data from the k-space data and generate a beam gating control signal based on the central k-space data. A computer-implemented method for generating a control signal for a radiotherapy device and a computer-readable medium comprising computer-executable instructions are also provided.

Abstract: A radiotherapy device, a computer-implemented method and a computer-readable medium are provided. The radiotherapy device comprises an accelerating structure, a magnetron and a controller communicatively coupled to the accelerating structure and the magnetron. The controller is configured to determine a predicted resonant frequency change of the accelerating structure based on an predicted operation of the radiotherapy device. The controller is further configured to adjust an output frequency of the magnetron by the predicted resonant frequency change.

Abstract: The present invention provides multispecific antibodies comprising a Fab region and an Fc region, wherein the Fab region comprises a binding site specific for an epitope of the variable delta 1 (V?1) chain of a ?? T cell receptor (TCR); and the Fe region comprises an EGFR binding site. The present invention also provides compositions and pharmaceutical compositions comprising such multispecific antibodies, and method of making such multispecific antibodies. The present invention also provides methods of treatment and medical uses involving the multispecific antibodies.

Abstract: Devices, systems and techniques are used for cancer treatment. An example control device may be configured to be communicatively coupled to a radiation source of a radiotherapy device and a position sensor of the radiotherapy device. The example control device may be used to calculate, for a sliding window of a radiotherapy treatment, a positional error between: a measured target position signal determined from a series of images and sampled at the acquisition times of the images, and an estimated target position signal. The example control device may generate a computer-executable instruction configured to alter the radiotherapy treatment in response to the positional error violating a threshold.

Abstract: Timing-based methods, systems, and computer readable mediums for a gated linear accelerator include synchronising a local clock of the linear accelerator with a clock of a patient monitoring system, determining latencies within one or more MR-gated radiotherapy processes and implementing latency based interlocks.

Abstract: A dermatoscope includes features to allow a practitioner to visualize a selected skin area of a patient by means of a self-contained portable tool. The same tool may be thereafter used to perform a desired biopsy of skin findings previously visualized. The same tool allows the site to be prepared for such biopsy by application of an adhesive bandage and such adhesive bandage may likewise be closed by the same tool by means of suitable structures within the dermatoscope.

Abstract: A quality assurance method for a radiotherapy device is disclosed. The method comprises disposing a phantom on a patient couch of the radiotherapy device, moving the patient couch to simulate motion of a subject, determining a measured value associated with the phantom, and comparing the measured value to an expected value. A radiotherapy device is also disclosed, the radiotherapy device comprising a radiation source configured to apply a radiation beam, a patient couch, a phantom disposable on the patient couch, and a controller communicatively coupled to the patient couch. A computer-readable medium storing instructions is also disclosed. A phantom for a radiotherapy device is also disclosed.

Abstract: The present invention provides high-affinity anti-TCR delta variable 1 (anti-V?1) antibodies and antibody fragments thereof. The present invention also provides compositions and pharmaceutical compositions comprising such antibodies, and method of making such antibodies. The present invention also provides methods of treatment and medical uses involving the antibodies.

Abstract: Disclosed herein is a method of characterising physical properties of an attenuating element in a radiotherapy device having a radiotherapy radiation source and a radiotherapy radiation detector on respective sides of the attenuating element. The method comprises obtaining an average detected radiotherapy radiation intensity at two or more locations around the attenuating element, comparing the detected intensity at one location with the average intensity, and characterising a corresponding physical property based on the comparison.

Abstract: Techniques for providing information about a current state modeled with multiple attributes is described. The providing of information can include receiving from a first source an indication of an ability to supply values for one of the state attributes of the modeled current state, and supplying to a client a value for the one attribute received from the first source. After the supplying of the value, the providing can include receiving from a second source a value supplying ability for the one attribute and supplying of a value for the one attribute based on values received for the one attribute from the first and second sources. After the supplying of that value, the providing can include receiving from the first source an indication of a value supplying inability for the one attribute and supplying a value for the one attribute received from the second source.

Abstract: Techniques for providing information about a current state modeled with multiple attributes is described. The providing of information can include receiving from a first source an indication of an ability to supply values for one of the state attributes of the modeled current state, and supplying to a client a value for the one attribute received from the first source. After the supplying of the value, the providing can include receiving from a second source a value supplying ability for the one attribute and supplying of a value for the one attribute based on values received for the one attribute from the first and second sources. After the supplying of that value, the providing can include receiving from the first source an indication of a value supplying inability for the one attribute and supplying a value for the one attribute received from the second source.

Abstract: Extended release formulations of S-methyladenosylmethionine (SAMe) are provided, as are methods of treating various disorders using extended release SAMe formulations. The extended release formulations may be used to treat a variety of disorders, including liver disorders, psychiatric disorders and joint disorders. Thus, extended release SAMe formulations may be used to treat alcoholic liver disease, fatty liver disease, hepatitis, generalized anxiety disorder, obsessive compulsive disorder, post traumatic stress disorder, panic disorder, and depressive disorders such as depression (e.g. major clinical depression) and dysthymia.

Abstract: Extended release formulations of S-methyladenosylmethionine (SAMe) are provided, as are methods of treating various disorders using extended release SAMe formulations. The extended release formulations may be used to treat a variety of disorders, including liver disorders, psychiatric disorders and joint disorders. Thus, extended release SAMe formulations may be used to treat alcoholic liver disease, fatty liver disease, hepatitis, generalized anxiety disorder, obsessive compulsive disorder, post traumatic stress disorder, panic disorder, and depressive disorders such as depression (e.g. major clinical depression) and dysthymia.

Abstract: Extended release formulations of S-methyladenosylmethionine (SAMe) are provided, as are methods of treating various disorders using extended release SAMe formulations. The extended release formulations may be used to treat a variety of disorders, including liver disorders, psychiatric disorders and joint disorders. Thus, extended release SAMe formulations may be used to treat alcoholic liver disease, fatty liver disease, hepatitis, generalized anxiety disorder, obsessive compulsive disorder, post traumatic stress disorder, panic disorder, and depressive disorders such as depression (e.g. major clinical depression) and dysthymia.

Abstract: Techniques for providing information about a current state modeled with multiple attributes is described. The providing of information can include receiving from a first source an indication of an ability to supply values for one of the state attributes of the modeled current state, and supplying to a client a value for the one attribute received from the first source. After the supplying of the value, the providing can include receiving from a second source a value supplying ability for the one attribute and supplying of a value for the one attribute based on values received for the one attribute from the first and second sources. After the supplying of that value, the providing can include receiving from the first source an indication of a value supplying inability for the one attribute and supplying a value for the one attribute received from the second source.

Abstract: Techniques are described for providing information about a current state that is represented with multiple attributes. In some situations, the providing includes a first computer receiving indications of multiple characterization modules, each characterization module executing on a computer to model an aspect of a current state related to that computer; receiving an indication of one of the multiple attributes of the represented current state; determining multiple of the characterization modules whose modeled aspects are related to the indicated one attribute; and gathering information about the modeled aspects related to the indicated one attribute from the determined characterization modules so that a value for the indicated one attribute can be generated based on the gathered information.

Abstract: Techniques for providing information about a current state modeled with multiple attributes is described. The providing of information can include receiving from a first source an indication of an ability to supply values for one of the state attributes of the modeled current state, and supplying to a client a value for the one attribute received from the first source. After the supplying of the value, the providing can include receiving from a second source a value supplying ability for the one attribute and supplying of a value for the one attribute based on values received for the one attribute from the first and second sources. After the supplying of that value, the providing can include receiving from the first source an indication of a value supplying inability for the one attribute and supplying a value for the one attribute received from the second source.

Abstract: Techniques are described for providing information about a current state that is modeled with multiple state attributes. In some situations the providing includes receiving from a first client an indication of an interest in receiving values for an indicated one of the state attributes of the modeled current state, receiving from a second client an indication of an interest in receiving values for another of the state attributes of the modeled current state, and, in response to receiving a value for the indicated one attribute from a first source, determining that the first client has an interest in receiving the received value and supplying the received value to the first client.

Abstract: Techniques for providing information about a current state modeled with multiple attributes is described. The providing of information can include receiving from a first source an indication of an ability to supply values for one of the state attributes of the modeled current state, and supplying to a client a value for the one attribute received from the first source. After the supplying of the value, the providing can include receiving from a second source a value supplying ability for the one attribute and supplying of a value for the one attribute based on values received for the one attribute from the first and second sources. After the supplying of that value, the providing can include receiving from the first source an indication of a value supplying inability for the one attribute and supplying a value for the one attribute received from the second source.