Patents by Inventor Joshua G. Pierce

Joshua G. Pierce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230390403
    Abstract: Disclosed herein are methods for drug delivery, as well as kits for drug delivery.
    Type: Application
    Filed: October 14, 2021
    Publication date: December 7, 2023
    Inventors: Yevgeny Brudno, Sharda Pandit, Sandeep Palvai, Tiffany Ferrell, Joshua G. Pierce, Nicholas Massaro, Chris Moody
  • Patent number: 11673869
    Abstract: Provided herein are oxazolidinone derivatives that can exhibit anti-microbial activity and/or activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity anti-microbial activity (e.g., potent activity against Gram-positive positive bacteria including methicillin-resistant Staphylococcus aureus). The compounds can exhibit potent activity against biofilms. In some cases, the compounds can exhibit both anti-microbial activity and biofilm modulation properties.
    Type: Grant
    Filed: November 23, 2020
    Date of Patent: June 13, 2023
    Assignee: North Carolina State University
    Inventors: Joshua G. Pierce, Jonathan J. Mills
  • Patent number: 11370812
    Abstract: Provided herein are isotopically labeled reagents, including isotopically labeled small molecules and peptides, that can be used to detect and/or quantify ?-N-methylamino-L-alanine (BMAA) in a sample. The reagents can be used as stable isotope labeled standards in analytical methods, including in conjunction with mass spectrometry, to detect and/or quantify BMAA in a sample, such as a protein sample from a subject.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: June 28, 2022
    Assignee: North Carolina State University
    Inventors: David C. Muddiman, Philip L. Loziuk, Joshua G. Pierce, Gavin Williams, Yasamin Moazami
  • Patent number: 11352333
    Abstract: Provided herein are compounds that can exhibit activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity against Gram positive biofilms. The compounds can also exhibit activity against Gram negative biofilms. In some cases, the compounds can exhibit both biofilm modulation properties and antimicrobial activity. Compositions comprising these compounds, as well as methods of using thereof, are also described. For example, the compounds described herein can be used in human and animal health (e.g., for the treatment of infection), agriculture, marine coatings, and other coating applications related to prevention of biofilm (e.g., dental, medical, etc.).
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: June 7, 2022
    Assignee: North Carolina State University
    Inventors: Joshua G. Pierce, Grant A. Edwards
  • Publication number: 20210323934
    Abstract: Provided herein are oxazolidinone derivatives that can exhibit anti-microbial activity and/or activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity anti-microbial activity (e.g., potent activity against Gram-positive positive bacteria including methicillin-resistant Staphylococcus aureus). The compounds can exhibit potent activity against biofilms. In some cases, the compounds can exhibit both anti-microbial activity and biofilm modulation properties.
    Type: Application
    Filed: November 23, 2020
    Publication date: October 21, 2021
    Inventors: Joshua G. Pierce, Jonathan J. Mills
  • Publication number: 20210317093
    Abstract: Provided herein are compounds that can exhibit activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity against Gram positive biofilms. The compounds can also exhibit activity against Gram negative biofilms. In some cases, the compounds can exhibit both biofilm modulation properties and antimicrobial activity. Compositions comprising these compounds, as well as methods of using thereof, are also described. For example, the compounds described herein can be used in human and animal health (e.g., for the treatment of infection), agriculture, marine coatings, and other coating applications related to prevention of biofilm (e.g., dental, medical, etc.).
    Type: Application
    Filed: November 2, 2020
    Publication date: October 14, 2021
    Inventors: Joshua G. Pierce, Grant A. Edwards
  • Patent number: 10844025
    Abstract: Provided herein are oxazolidinone derivatives that can exhibit anti-microbial activity and/or activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity anti-microbial activity (e.g., potent activity against Gram-positive positive bacteria including methicillin-resistant Staphylococcus aureus). The compounds can exhibit potent activity against biofilms. In some cases, the compounds can exhibit both anti-microbial activity and biofilm modulation properties.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: November 24, 2020
    Assignee: North Carolina State University
    Inventors: Joshua G. Pierce, Jonathan J. Mills
  • Patent number: 10822315
    Abstract: Provided herein are compounds that can exhibit activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity against Gram positive biofilms. The compounds can also exhibit activity against Gram negative biofilms. In some cases, the compounds can exhibit both biofilm modulation properties and antimicrobial activity. Compositions comprising these compounds, as well as methods of using thereof, are also described. For example, the compounds described herein can be used in human and animal health (e.g., for the treatment of infection), agriculture, marine coatings, and other coating applications related to prevention of biofilm (e.g., dental, medical, etc.).
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: November 3, 2020
    Assignee: North Carolina State University
    Inventors: Joshua G. Pierce, Grant A. Edwards
  • Publication number: 20200290950
    Abstract: The present disclosure relates to alkamide compounds and compositions for treating allergic diseases, pain, or itch.
    Type: Application
    Filed: October 5, 2018
    Publication date: September 17, 2020
    Inventors: Scott M. LASTER, Travis V. GULLEDGE, Joshua G. PIERCE, Wolfgang BAEUMER, Santosh K. MISHRA
  • Publication number: 20190210982
    Abstract: Provided herein are compounds that can exhibit activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity against Gram positive biofilms. The compounds can also exhibit activity against Gram negative biofilms. In some cases, the compounds can exhibit both biofilm modulation properties and antimicrobial activity. Compositions comprising these compounds, as well as methods of using thereof, are also described. For example, the compounds described herein can be used in human and animal health (e.g., for the treatment of infection), agriculture, marine coatings, and other coating applications related to prevention of biofilm (e.g., dental, medical, etc.).
    Type: Application
    Filed: August 22, 2017
    Publication date: July 11, 2019
    Inventors: Joshua G. Pierce, Grant A. Edwards
  • Publication number: 20190177285
    Abstract: Provided herein are oxazolidinone derivatives that can exhibit anti-microbial activity and/or activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity anti-microbial activity (e.g., potent activity against Gram-positive positive bacteria including methicillin-resistant Staphylococcus aureus). The compounds can exhibit potent activity against biofilms. In some cases, the compounds can exhibit both anti-microbial activity and biofilm modulation properties.
    Type: Application
    Filed: August 22, 2017
    Publication date: June 13, 2019
    Inventors: Joshua G. Pierce, Jonathan J. Mills
  • Publication number: 20190161515
    Abstract: Provided herein are isotopically labeled reagents, including isotopically labeled small molecules and peptides, that can be used to detect and/or quantify ?-N-methylamino-L-alanine (BMAA) in a sample. The reagents can be used as stable isotope labeled standards in analytical methods, including in conjunction with mass spectrometry, to detect and/or quantify BMAA in a sample, such as a protein sample from a subject.
    Type: Application
    Filed: July 31, 2017
    Publication date: May 30, 2019
    Inventors: David C. Muddiman, Philip L. Loziuk, Joshua G. Pierce, Gavin Williams, Yasamin Moazami